Publications by authors named "Changqing Sun"

Depression, anxiety, and stress are major mental health challenges during children's development. In China, heightened sleep disorders (SD), parental expectations, and academic stress highlight the importance of this issue. A total of 6,635 SD child-parent dyads were included in analysis.

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Background: Blood urea nitrogen (BUN) reflects renal function and protein metabolism, while the platelet-to-lymphocyte ratio (PLR) is a common inflammatory marker. Though studied in adults, their relationship with children is unclear. This study aims to explore this association in children aged 12-18 years using National Health and Nutrition Examination Survey (NHANES) 2009-2018 data and evaluate PLR as a potential non-invasive marker for renal function.

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Background: Medical students frequently face mental health challenges, underscoring the need for prompt identification and intervention. This research is designed to explore the interconnections between depression, anxiety, and academic engagement among medical students in the Post-Peak COVID-19 in China, employing a network analysis approach.

Method: In this research, 928 medical students were enrolled.

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Background: Multimorbidity may influence biological aging, particularly in acute ischemic stroke (AIS) patients with high comorbidity burden. However, evidence on associations between multimorbidity and biological aging in AIS remains limited, with unclear differential impacts of specific multimorbidity clusters. This study evaluated latent multimorbidity patterns in AIS patients and quantified relationships between multimorbidity and biological age (BA) acceleration.

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Water use efficiency (WUE) connects two key processes in terrestrial ecosystems: the carbon and water cycles. Thus, it is important to evaluate temporal and spatial changes in WUE over a prolonged period. The spatiotemporal variation characteristics of the WUE in the Mongolian Plateau from 1982 to 2018 were analyzed based on the net primary productivity (NPP), evapotranspiration (ET), temperature, precipitation, and soil moisture.

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Background: Each year, there are approximately 10.3 million new stroke cases worldwide, with 2 million occurring in China. Post-stroke depression (PSD) is a common complication that negatively affects rehabilitation outcomes and increases long-term mortality.

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A water-soluble polysaccharide from foxtail millet (FM-D1) was isolated and purified through gradient ethanol precipitation and column chromatography. Size-Exclusion Chromatography-Multi-Angle Light Scattering-Refractive Index (SEC-MALLS-RI) and high-performance anion-exchange chromatography (HPAEC) analyses revealed that FM-D1 constitutes a highly purified neutral polysaccharide exclusively composed of glucose as the sugar unit, with a molecular weight of 14.823 kDa.

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Background: Psychological health is crucial for the physical and mental well-being of primary and secondary school students, however, the research on the interrelationships among negative emotions is still limited. This study aims to investigate the network structure of depression, anxiety, and stress, and explore their correlation with screen time in these populations.

Method: This study was conducted from March to July 2022 in 157 counties across 18 cities in Henan Province.

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Objective: Our research explores how leisure-time sedentary behavior (SB) correlates with stroke risk. Additionally, we utilize the isotemporal substitution model (ISM) to examine how replacing brief durations of leisure-time SB with light physical activity (LPA), moderate physical activity (MPA), vigorous physical activity (VPA), and sleep might influence the risk of stroke.

Methods: This investigation tracked 478,198 participants from the UK Biobank.

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Article Synopsis
  • Gastrointestinal tumors are a major health issue in Asia, and this study examines their impact over the last three decades using data from the Global Burden of Disease Study 2021.
  • Among these tumors, stomach cancer (SC) had the highest disease burden in 2021, while colorectal cancer (CRC) showed a significant increase in incidence rates.
  • There are notable age and gender differences in the disease burden, with older males at higher risk, and East Asia experiencing a greater impact compared to other regions.
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Article Synopsis
  • Higher levels of medium-chain fatty acids (MCFAs) like octanoic acid and docosahexaenoic acid (DHA) are linked to a reduced risk of mild cognitive impairment (MCI).
  • The study examined data from a cohort of elderly individuals, using regression analysis to compare those with MCI to matched controls, revealing significant associations between fatty acid levels and MCI risk.
  • Mitochondrial factors such as β-hydroxybutyrate (BHB) and mitochondrial DNA (mtDNA) copy number play mediating roles in these associations, suggesting they influence how MCFAs and DHA impact cognitive health.
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Prediabetes is an early phase before diabetes. Diabetes and dietary inflammation are two crucial factors that are strongly associated with cardiovascular diseases (CVDs). Dietary interventions slowed the progression of diabetes and CVD.

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Background: Anxiety, depression, and sleep problems are prevalent comorbid mental disorders among university students. The World Health Organization (WHO) emphasized a mental health promotion objective, recommending the consideration of protective health-promoting factors in strategies aimed at preventing mental disorders. Integrating theoretically significant constructs (such as protective factors) enhances our comprehension of the intricate mechanisms that underpin mental disorders.

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Article Synopsis
  • Japanese encephalitis (JE) is a major health issue in China, contributing to approximately 80% of global cases; this study aimed to analyze its epidemiological trends using data from 2004 to 2019.
  • Over the study period, there were 43,569 reported cases of JE, with a notable decline in annual incidence rates from 0.4171/100,000 in 2004 to 0.0298/100,000 in 2019, and deaths also showing a decreasing trend despite some fluctuations.
  • The findings highlight the need for enhanced disease surveillance, vaccination efforts, and public awareness, especially among the 0-14 age group, which constitutes nearly 80% of cases
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According to stoichiometric homeostasis theory, eutrophication is expected to increase the dominance of submerged macrophytes with low homeostatic regulation coefficients (H) relative to those with high H values, ultimately reducing macrophyte community stability. However, empirical evidence supporting this hypothesis is limited. In this study, we conducted a three-year tracking survey (seven sampling events) at 81 locations across three regions of Erhai Lake.

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Background: Chronic diseases have a high prevalence worldwide, and patients with chronic diseases often suffer from depression, leading to a poor prognosis and a low quality of life. Metacognitive therapy is a transdiagnostic psychotherapy intervention focused on thinking patterns, with the advantages of reliable implementation effect, short intervention period and low cost. It can help patients change negative metacognition, alleviate depression symptoms, and has a higher implementation value compared with other cognitive interventions.

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The risk of pressure ulcers in stroke patients is a significant concern, impacting their recovery and quality of life. This systematic review and meta-analysis investigate the prevalence and risk factors of pressure ulcers in stroke patients, comparing those in healthcare facilities with those in home-based or non-clinical environments. The study aims to elucidate how different care settings affect the development of pressure ulcers, serving as a crucial indicator of patient care quality and management across diverse healthcare contexts.

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Article Synopsis
  • The study aimed to find biomarkers for hepatitis B virus-associated hepatocellular carcinoma (HBV-HCC) and created a new diagnostic panel with improved accuracy.
  • Four candidate tumor-associated autoantibodies (anti-ZIC2, anti-CDC37L1, anti-DUSP6, and anti-PCNA) were identified and validated through various testing phases, with some showing better performance than the commonly used alpha-fetoprotein (AFP).
  • The final diagnostic panel that included three of these autoantibodies demonstrated a higher detection rate for early HBV-HCC, especially in AFP-negative cases, suggesting it could complement existing diagnostic methods for more accurate identification of the disease.
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Emergency craniotomy in patients with traumatic brain injury poses a significant risk for surgical site infections (SSIs). Understanding the risk factors and pathogenic characteristics of SSIs in this context is crucial for improving outcomes. This comprehensive retrospective analysis spanned from February 2020 to February 2023 at our institution.

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The relationship between gut microbiota and its metabolites with cardiovascular disease (CVD) has been proven. In this review, we aim to conclude the potential mechanism of gut microbiota and its metabolites on inducing the formation of vulnerable atherosclerotic plaque, and to discuss the effect of intestinal metabolites, including trimethylamine-N-oxide (TMAO), lipopolysaccharide (LPS), phenylacetylglutamine (PAG), short-chain fatty acids (SCFAs) on plaque stability. Finally, we include the impact of gut microbiota and its metabolites on plaque stability, to propose a new therapeutic direction for coronary heart disease.

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Purpose: The relationship between circulating 25-hydroxyvitamin D [25(OH)D] and pancreatic cancer has been well studied but remains unclear. The purpose of this study was to elucidate the association between circulating 25(OH)D and pancreatic cancer by using a meta-analytic approach.

Methods: PubMed, Embase, and Wed of Science databases were searched through October 15, 2022.

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Over 16 million children have been detected positive for the coronavirus disease 2019 (COVID-19) in the United States since the outbreak of the pandemic. In general, children infected with severe acute respiratory syndrome coronavirus type 2 tend to have lighter symptoms than adults. However, in some cases, the infection can develop into severe forms, such as multisystem inflammatory syndrome in children.

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Importance: Apolipoprotein E polymorphism ε4 (APOE ε4) and methylenetetrahydrofolate reductase (MTHFR) TT genotype are genetic risk factors of mild cognitive impairment (MCI), but whether this risk can be changed by modifiable lifestyle factors is unknown.

Objective: To explore whether unhealthy lifestyle (unhealthy dietary intake, current smoking, nonlimited alcohol consumption, and irregular physical activities) is associated with a higher risk of age-related MCI considering genetic risk.

Design, Setting, And Participants: This population-based cohort study used data from Tianjin Elderly Nutrition and Cognition (TENC) study participants, recruited from March 1, 2018, through June 30, 2021, and followed up until November 30, 2022.

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