K-point stimulation combined with temperature-differential herbal oral care in improving post-stroke dysphagia.

Objectives: To evaluate the efficacy of K-point stimulation combined with temperature-differential herbal oral care in improving swallowing function.

Design: A retrospective cohort study.

Methods: Patients treated between January 2022 and December 2023 were divided into a control group (routine care) and an observation group (routine care plus K-point stimulation combined with temperature-differentiated herbal oral care).

Progranulin (PGRN) Facilitates Anti-Inflammation and Pulpitis Repair In Vivo and In Vitro Through TNFR2/14-3-3ε Signalling Complex.

Aim: To investigate the role and mechanism of progranulin (PGRN) in reparative dentinogenesis and inflammation control for rat pulpitis and inflammatory human dental pulp stem cells (hDPSCs).

Methodology: Eight-week-old male Wistar rats with irreversible pulpitis were treated with pulpotomy and divided into five groups: No treatment; Control; iRoot BP plus (BP); GelMA and recombinant human PGRN (rhPGRN) + GelMA (rhPGRN). Micro-computed tomography (Micro-CT) scans and histological and immunohistochemical staining were conducted to evaluate rhPGRN' anti-inflammation and pro-healing properties.

LINC01088 Targets miR-195-5p to Promote Proliferation and Migration and Reduce Apoptosis in the Inhibition of Carotid Artery Stenosis.

Carotid artery stenosis (CAS) often goes undetected until it reaches an advanced stage, which can result in serious complications. The present study evaluated the potential of long noncoding RNA (lncRNA) LINC01088 as a biomarker for CAS. 92 CAS patients and 92 healthy controls (Control group) were included.

Identification of metabolism-related subtypes and feature genes of pre-eclampsia.

The heterogeneity of pre-eclampsia (PE) complicates its pathogenesis, which remains incompletely understood. Emerging evidence indicates a significant role of metabolism in the pathophysiology of PE. We procured the PE dataset from the Gene Expression Omnibus database and sourced a published compilation of metabolism-related genes, then employed consensus clustering to classify PE subtypes.

The Clinical Value of LINC01094/Hsa-miR-4758-5p and Their Action Mechanisms in Carotid Artery Stenosis.

Carotid artery stenosis (CAS) is mostly caused by carotid atherosclerotic plaque, leading to various cardiovascular and cerebrovascular diseases that seriously threaten human lives. This study aims to explore the roles of LINC01094 and hsa-miR-4758-5p in CAS pathogenesis and provide theoretical support for its prediction and treatment. RT-qPCR was used to detect the levels of LINC01094 and hsa-miR-4758-5p.

Simvastatin inhibits proliferation and promotes apoptosis of oral squamous cell carcinoma through KLF2 signal.

Objectives: This study aimed to explore the role and specific mechanism of the cholesterol-lowering drug simvastatin in inhibiting oral squamous cell carcinoma (OSCC).

Methods: The proliferation, apoptosis, and migration levels of OSCC cells were detected by CCK8, quantitative real-time polymerase chain reaction, Western blot, colony formation, TdT-mediated dUTP Nick-End Labeling assay, and wound healing assay. The inhibitory effect of simvastatin in vivo was detected by a mouse xenograft tumor model.

Oral verrucous xanthoma with oral lichen planus: a case report.

Verrucous xanthoma is a rare benign muco-cutaneous lesion, whereas oral lichen planus is a chronic inflammatory disease relatively common in the clinical setting. Verrucous xanthoma and oral lichen planus can reportedly coexist according to foreign literature. Owing to the low incidence of verrucous xanthoma and the rarity of co-occurrence of these two diseases, the mechanism underlying the co-occurrence of the two diseases remains inconclusive.

Lower lip recurrent keratoacanthoma: A case report.

Background: This paper introduces a case of recurrent keratoacanthoma (KA). KA is a self-healing disease. Recurrence after surgical resection is rare.

Diagnostic value of objective VELscope fluorescence methods in distinguishing oral cancer from oral potentially malignant disorders (OPMDs).

Background: The VELscope fluorescence method has been applied to the identification and detection of oral potentially malignant disorders, but autofluorescence visualization lacks objectivity and its diagnostic value varies greatly. The effectiveness of VELscope in detection of the cancer risk in oral potentially malignant disorders at different lesion sites remains unclear, given that only a few studies have investigated the value of VELscope for detecting high- and low-risk lesions in oral potentially malignant disorders. This study used the objective VELscope fluorescence method based on quantitative analysis to investigate its value in oral potentially malignant disorders for: (I) detecting oral cancer; (II) distinguishing high-risk lesions from low-risk lesions; and (III) measuring differences in oral cancer diagnostic accuracy between different sites.

Design and Synthesis of Novel PRMT1 Inhibitors and Investigation of Their Effects on the Migration of Cancer Cell.

Protein arginine methyltransferase 1 (PRMT1) can catalyze the protein arginine methylation by transferring the methyl group from S-adenosyl-L-methionine (SAM) to the guanidyl nitrogen atom of protein arginine, which influences a variety of biological processes including epithelial-mesenchymal transition (EMT) and EMT-mediated mobility of cancer cells. The upregulation of PRMT1 is involved in a diverse range of cancer, such as lung cancer, and there is an urgent need to develop novel and potent PRMT1 inhibitors. In this article, a series of 2,5-substituted furan derivatives and 2,4-substituted thiazole derivatives were designed and synthesized by targeting at the substrate arginine-binding site on PRMT1, and 10 compounds demonstrated significant inhibitory effects against PRMT1.

Protective effect of polysaccharides from morinda officinalis on bone loss in ovariectomized rats.

In order to examine the effect of polysaccharides from morinda officinalis (MOP) on bone quality of osteoporosis rats. The osteoporosis in rats was induced by ovariectomy, and MOP (100 or 300 mg/kg) was orally administrated once daily. The animals were assessed 30 days after the operation for bone mineral density, serum cytokines level and mineral element concentration.