Ultrahigh-Capacity Sodium Storage in Long-range Ordered Expanded Flake Graphite: Insights into the Underlying Mechanism.

The narrow interlayer spacing of natural graphite, commonly used in lithium-ion batteries, restricts the effective intercalation of Na⁺ and leads to sluggish diffusion kinetics. Herein, expanded flake graphite (EFG) with long-range ordered structure and enlarged interlayer spacing is synthesized by stepwise oxidation and high-temperature microstructure control technology using large flake graphite. Electrochemical tests and density functional theory (DFT) calculations validate that the long-range ordered structure is more favorable to reduce the migration energy barrier of Na compared to the expanded interlayer spacing, which effectively enhances the sodium storage performance.

Sleep quality types and influencing factors of frail elderly in long-term care facilities: A latent profile analysis.

This study aims to investigate distinct categories of sleep quality among frail elderly residents in long-term care facilities using latent profile analysis and to analyze the factors influencing these categories. A convenience sample of 309 frail elderly individuals from three long-term care facilities in Xinjiang was surveyed between November 2023 and January 2024. Data were collected utilizing a general information questionnaire and the Pittsburgh Sleep Quality Index (PSQI).

ROS-Mediated Overexpression by AMPKα Confers Resistance to Dimefluthrin and Cross-Resistance to Indoxacarb in .

Increased electron respiratory chain complex and Na, K-ATPase activity, ROS content, and expression, and decreased free ATP content were detected in a dimefluthrin-resistant () strain established in laboratory, which developed high-level resistance to dimefluthrin and cross-resistance to indoxacarb and the resistance ratio of 21.61- and 62.14-fold shifted to 8.

KRAS regulates IL-17 signal activity by affect the metastasis of osteosarcoma via an IL-17A-dependent manner.

Dysregulation of Kirsten rat sarcoma virus (KRAS) plays crucial roles in many tumors. It is reported that KRAS could promote proliferation of osteosarcoma (OS) cells. Nonetheless, the contribution of KRAS to the invasion and spread of OS is still not well understood.

Zinc oxide nanoparticles mitigate the malignant progression of ovarian cancer by mediating autophagy-dependent ferroptosis.

Background: Previous studies have shown that ZnO-NPs induce autophagy and inhibit the malignant progression of ovarian cancer (OC) cells. This study aims to further explore the mechanism of action of ZnO-NPs on OC.

Methods: SKOV3 cells were treat with different concentrations of ZnO-NPs and cell proliferation was assessed through EDU staining.

The role and potential treatment of macrophages in patients with infertility and endometriosis.

Endometriosis is characterized as a macrophage-related ailment due to its strong link with immune dysfunction. Understanding the status of macrophage polarization in the context of endometriosis-related infertility is crucial for advancing diagnostic and therapeutic strategies. Our comprehensive review delves into the foundational understanding of macrophages and their profound influence on both endometriosis and infertility.

Delayed simvastatin treatment improves neurological recovery after cryogenic traumatic brain injury through downregulation of ELOVL1 by inhibiting mTOR signaling.

Statins are well-tolerated and widely available lipid-lowering medications with neuroprotective effects against traumatic brain injury (TBI). However, whether delayed statin therapy starting in the subacute phase promotes recovery after TBI is unknown. Elongation of the very long-chain fatty acid protein 1 (ELOVL1) is involved in astrocyte-mediated neurotoxicity, but its role in TBI and the relationship between ELOVL1 and statins are unclear.

Effects of Replacing Soybean Meal with Cottonseed Meal, Peanut Meal, Rapeseed Meal, or Distillers' Dried Grains with Solubles on the Growth Performance, Nutrient Digestibility, Serum Parameters, and Rumen Fermentation in Growing Lambs.

Considering the frequently large price fluctuations for soybean meal, an alternative is the increased use of locally produced high-protein ingredients. The objective of this study was to evaluate the effects of the total replacement of soybean meal with different sources of protein on the growth performance, nutrient digestibility, serum parameters, rumen fermentation parameters, and bacterial communities in growing lambs. Sixty sheep with similar body weights (38.

Targeting astrocytic TDAG8 with delayed CO postconditioning improves functional outcomes after controlled cortical impact injury in mice.

T-cell death-associated gene 8 (TDAG8), a G-protein-coupled receptor sensing physiological or weak acids, regulates inflammatory responses. However, its role in traumatic brain injury (TBI) remains unknown. Our recent study showed that delayed CO postconditioning (DCPC) has neuroreparative effects after TBI.

Separators Modified with Ultrathin Montmorillonite/Polymer Nanocoatings Achieve Dendrite-Free Lithium Deposition at High Current Densities.

Fatal dendritic growth in lithium metal batteries is closely related to the composition and thickness of the modified separator. Herein, an ultrathin nanocoating composed of monolayer montmorillonite (MMT), poly(vinyl alcohol) (PVA) on a polypropylene separator is prepared. The MMT was exfoliated into monolayers (only 0.

Targeting Neuronal GPR65 With Delayed BTB09089 Treatment Improves Neurorehabilitation Following Ischemic Stroke.

Background: GPR65 (G protein-coupled receptor 65) can sense extracellular acidic environment to regulate pathophysiological processes. Pretreatment with the GPR65 agonist BTB09089 has been proven to produce neuroprotection in acute ischemic stroke. However, whether delayed BTB09089 treatment and neuronal GPR65 activation promote neurorestoration remains unknown.

miR-34b-5p suppresses the epithelial-mesenchymal transition and metastasis in endometrial cancer AN3CA cells by targeting .

Objectives: Tumor metastasis is a primary cause of recurrence and mortality in endometrial cancer. miR-34b-5p is abnormally expressed in various cancers and participates in tumor cell progression and metastasis. The objective of this study was to elucidate the biological functions and molecular mechanisms of miR-34b-5p in regulating the epithelial-mesenchymal transition (EMT) and metastasis in AN3CA endometrial cancer cells.

Anxiety symptoms without depression are associated with cognitive control network (CNN) dysfunction: An fNIRS study.

Anxiety is a common psychological disorder associated with other mental disorders, with depression being the most common comorbidity. Few studies have examined the neural mechanisms underlying anxiety after controlling for depression. This study aimed to explore whether there are differences in cortical activation in anxiety patients with different severities whose depression are normal.

Practice guideline on ovarian tissue cryopreservation and transplantation in the prevention and treatment of iatrogenic premature ovarian insufficiency.

Premature ovarian insufficiency (POI) refers to the decline of ovarian function before the age of 40. POI causes a reduction in or loss of female fertility, accompanied by different degrees of menopausal symptoms, which increases the risk of chronic diseases related to early menopause and seriously affects patients' quality of life and health. It is conservatively estimated that at least one million prepubertal girls and women of reproductive age in China are at risk of iatrogenic POI caused by radiotherapy and chemotherapy every year.

Differential Adsorption of Dissolved Organic Matter and Phosphorus on Clay Mineral in Water-Sediment System.

Lake sediments connection to the biogeochemical cycling of phosphorus (P) and carbon (C) influences streamwater quality. However, it is unclear whether and how the type of sediment controls P and C cycling in water. Here, the adsorption behavior of montmorillonite (Mt) with different interlayer cations (Na, Ca, or Fe) on dissolved organic matter (DOM) and P was investigated to understand the role of Mt in regulating the organic carbon-to-phosphate (OC/P) ratio within freshwater systems.

Levosimendan Relaxes Thoracic Aortic Smooth Muscle in Mice by Inhibiting PKC and Activating Inwardly Rectifying Potassium Channels.

Studies have examined the therapeutic effect of levosimendan on cardiovascular diseases such as heart failure, perioperative cardiac surgery, and septic shock, but the specific mechanism in mice remains largely unknown. This study aimed to investigate the relaxation mechanism of levosimendan in the thoracic aorta smooth muscle of mice. Levosimendan-induced relaxation of isolated thoracic aortic rings that were precontracted with norepinephrine or KCl was recorded in an endothelium-independent manner.

Digital economy drives regional industrial structure upgrading: Empirical evidence from China's comprehensive big data pilot zone policy.

With the development of the digital economy, industrial structure upgrading plays an important role in realizing high-quality development. Exploiting the quasi-natural experimental setting provided by the Big Data Comprehensive Pilot Zone (BDCPZ) policy in China in 2016, this study evaluates the impacts of the BDCPZ policies on regional industrial structure upgrading using a combination of propensity score matching and difference-in-differences (PSM-DID) with panel data of 30 regions for the period 2008-2021. The results are as follows: (1) BDCPZ policies significantly promote regional industrial structure upgrading.

Zinc oxide nanoparticles inhibit malignant progression and chemotherapy resistance of ovarian cancer cells by activating endoplasmic reticulum stress and promoting autophagy.

The mortality rate of ovarian cancer (OC) is high, posing a serious threat to women's lives. Zinc oxide nanoparticles (ZnO-NPs) show great potential in the treatment of cancer. However, the mechanism of ZnO-NPs in inhibiting the malignant proliferation and chemotherapy resistance of OC has remained elusive.

Delayed CO postconditioning promotes neurological recovery after cryogenic traumatic brain injury by downregulating IRF7 expression.

Aims: Few treatments are available in the subacute phase of traumatic brain injury (TBI) except rehabilitation training. We previously reported that transient CO inhalation applied within minutes after reperfusion has neuroprotective effects against cerebral ischemia/reperfusion injury. In this study, it was hypothesized that delayed CO postconditioning (DCPC) starting at the subacute phase may promote neurological recovery of TBI.

Application of Biomedical Microspheres in Wound Healing.

Tissue injury, one of the most common traumatic injuries in daily life, easily leads to secondary wound infections. To promote wound healing and reduce scarring, various kinds of wound dressings, such as gauze, bandages, sponges, patches, and microspheres, have been developed for wound healing. Among them, microsphere-based tissue dressings have attracted increasing attention due to the advantage of easy to fabricate, excellent physicochemical performance and superior drug release ability.

Adhesive Composite Microspheres with Dual Antibacterial Strategies for Infected Wound Healing.

Skin damage and infection pose a severe challenge to human health. Construction of a novel versatile dressing with good anti-infection and healing-promoting abilities is greatly expected. In this paper, nature-source-based composite microspheres with dual antibacterial mechanisms and bioadhesive features by microfluidics electrospray for infected wound healing is developed.

Delayed Chronic Acidic Postconditioning Improves Poststroke Motor Functional Recovery and Brain Tissue Repair by Activating Proton-Sensing TDAG8.

Acidic postconditioning by transient CO inhalation applied within minutes after reperfusion has neuroprotective effects in the acute phase of stroke. However, the effects of delayed chronic acidic postconditioning (DCAPC) initiated during the subacute phase of stroke or other acute brain injuries are unknown. Mice received daily DCAPC by inhaling 5%/10%/20% CO for various durations (three cycles of 10- or 20-min CO inhalation/10-min break) at days 3-7, 7-21, or 3-21 after photothrombotic stroke.

Functionalized Halloysite Scaffold Controls Sodium Dendrite Growth.

Sodium metal is one of the most promising anodes for the prospective low-cost rechargeable batteries. Nevertheless, the commercialization of Na metal anodes remains restricted by sodium dendrite growth. Herein, halloysite nanotubes (HNTs) were chosen as the insulated scaffolds, and Ag nanoparticles were introduced as sodiophilic sites to achieve uniform sodium deposition from bottom to top under the synergistic effect.

Comprehensive analysis of BUBs gene family in lung adenocarcinoma with immunological analysis.

Lung adenocarcinoma (LUAD) is one of the most commonly malignant tumors, and major challenges remain in the treatment of LUAD. Budding uninhibited by benzimidazole 1/3 (BUB1/3) play significant roles in the process of spindle-assembly checkpoint (SAC) during mitosis. However, their roles in LUAD have not been established.