Factors influencing diagnostic delays in celiac disease.

Background: Celiac disease (CeD), an autoimmune disorder triggered by gluten ingestion, is characterized by non-specific clinical manifestations such as fatigue, abdominal pain, and nutritional deficiencies, often leading to substantial diagnostic delays. Prolonged delays (≥ 2 years from symptom onset) are associated with increased risks of complications like osteoporosis, small intestinal lymphoma, and reduced quality of life.

Aim: To estimate diagnostic delay prevalence and identify risk factors in Chinese CeD patients.

[miR-302a-3p targeting lysosomal-associated membrane protein 5 inhibits the invasion and metastasis of oral squamous cell carcinoma].

Objectives: This study aimed to explore the expression of lysosomal-associated membrane protein 5 (LAMP5) and microRNA (miR)-302a-3p in oral squamous cell carcinoma (OSCC) and their functional mechanism on the invasion and metastasis of OSCC.

Methods: The expression of LAMP5 in OSCC and its sensitivity as a prognostic indicator were analyzed on the basis of The Cancer Genome Atlas database. Western blot, quantitative reverse transcription polymerase chain reaction, and cell immunocytochemistry were used to detect the expression of LAMP5 in OSCC tissues and cells.

Extracellular vesicles enriched with miR-486 from Tetramethylpyrazine-preconditioned bone marrow mesenchymal stem cells promote microglia/macrophage M2 polarization and enhance neurogenesis in rats with ischemic stroke.

Background: Bone marrow mesenchymal stem cell-derived extracellular vesicles (BMSC-EVs) show therapeutic promise for ischemic stroke (IS). Preconditioning MSCs with drugs can modulate the cargo composition and function of their derived EVs. This study investigated the therapeutic effects and underlying mechanisms of EVs derived from tetramethylpyrazine (TMP)-preconditioned BMSCs (TMP-BMSC-EVs) in IS.

Implementing bedside electronic transfusion checks at Barts Health NHS Trust: A study protocol for evaluating the effectiveness and value for money.

Objective: To evaluate the benefits of implementing Bedside Electronic Transfusion Checks (BETC) to patients and value for money at four hospitals at Barts Health NHS Trust.

Background: BETC aims to enhance transfusion safety by reducing errors associated with positive patient identification checks for compatibility, blood sample labelling, and blood component administration. There is limited evidence on the potential benefits to patients and healthcare professionals as well as value for money for implementing BETC.

View Micronuclei in the Extent of Evolution: New Insight Into an Old Issue.

Micronuclei (MNs), once regarded as cellular debris or genotoxicity markers, can also be recognized as dynamic structures with potential evolutionary significance. In tumor models, MNs promote clonal diversification, mutagenesis, and adaptation. MNs' interaction with the conserved cGAS-STING pathway reflects dual roles in immune defense for the individual and adaptive response for cell under stress.

MRANet: Multi-Dimensional Residual Attentional Network for Precise Polyp Segmentation.

Automated polyp detection plays a critical role in the early diagnosis of colorectal cancer, ranking as the second leading cause of cancer-related mortality worldwide. However, existing segmentation methods face difficulties in handling complex polyp shapes, size variations, and generalising across diverse datasets. We propose a Multi-dimensional Residual Attention Network (MRANet) for the polyp segmentation task, focusing on enhancing feature representation and ensuring robust performance across diverse clinical scenarios.

The influence of human milk composition and its microbiome on the gut microecology and early growth and development of preterm infants (the YI study): protocol design and cohort profile.

Introduction: Breastfeeding can reduce the risk of serious illness in preterm infants. However, the influence of human milk on the gut microecology and early development of preterm infants remains unclear.

Methods: The YI Study is a prospective cohort protocol conducted in China, designed to investigate the dynamic associations among breast milk composition, infant gut microecology, and health from a mother-breastmilk-preterm infant triad perspective.

Effects of Remimazolam-Propofol with Flumazenil Reversal on the Emergence Time and Hemodynamics of Patients Undergoing Laparoscopic Partial Hepatectomy: A Prospective Randomized Controlled Trial.

Background: Laparoscopic partial hepatectomy, characterized by significant surgical trauma, profound stress responses, prolonged duration, and high anesthetic requirements, may lead to delayed recovery or emergence agitation. Whether remimazolam and propofol combined with flumazenil reversal can accelerate the recovery and enhance hemodynamic stability remains controversial.

Methods: Fifty patients aged 18-70 years with American Society of Anesthesiologists (ASA) class I-III and Child-Pugh classification A or B undergoing elective laparoscopic partial hepatectomy were enrolled.

MALAT1 overexpression contributes to choriocarcinoma by binding with RBM10 and promoting p53 degradation.

Background: Choriocarcinoma (CC), a highly aggressive and malignant subtype of gestational trophoblastic disease (GTD), arises from the dysregulated proliferation of trophoblastic cells, which normally mediate placental development during pregnancy. This study aimed to characterize the expression and functional significance of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a nuclear-enriched long non-coding RNA, in CC pathogenesis.

Methods: We analyzed MALAT1 expression levels in 30 normal placental villi, 46 hydatidiform moles (repressive subtype), and 52 CC specimens.

Compare the Effects of 0 mg/kg, 0.1 mg/kg, 0.3 mg/kg and 0.5 mg/kg Esketamine on Emergence Agitation After Tonsillectomy and Adenoidectomy in Children: A Randomized Control Trial.

Background: The probability of children experiencing emergence agitation (EA) in post-anesthesia care unit (PACU) undergoing adenoidectomy and tonsillectomy is up to 80%. This study investigated the effects of pre-anesthesia sedation of esketamine at 0mg/kg (Control group), 0.1mg/kg, 0.

A new strategy for preparing cemented paste backfill using red mud neutralized by phosphogypsum: Mechanical properties, hydration mechanism and production cost.

Red mud (RM) and phosphogypsum (PG) are hazardous wastes that are difficult to utilize extensively due to their high alkalinity and acidity. In this study, a new strategy for using RM neutralized by PG (P&R-composites) is proposed to prepare cemented paste backfill (PR-CPB), representing an environmental-friendly technology to place solid wastes into underground goafs. The corresponding effects of P&R-composites contents on the properties of PR-CPB were investigated by macroscopic and microscopic experiments.

Identifying ATP-Binding Cassette Member B5 as a New Biomarker for Oral Squamous Cell Carcinoma.

Background: Oral squamous cell carcinoma (OSCC) is the most common head and neck malignancy with a low five-year survival rate. ATP-binding cassette subfamily B member 5 (ABCB5) has been linked to tumorigenesis. However, its role in inducing OSCC remains unclear.

Separation of bidispersed microspheres in dusty plasma ratchet experiments.

It is demonstrated experimentally that the effective separation of bidispersed microspheres (dust particles) in the underdamped and strongly coupled regime is realized using a designed dusty plasma ratchet. Experimental findings reveal that these dust particles can undergo directional transport at varying speeds, even moving in opposite directions depending on the discharge conditions, enabling successful particle separation. Numerical simulations of the plasma environment surrounding the dust particles are performed using fluid simulations of the capacitively coupled discharge of Argon.

sublingual immunotherapy in pediatric patients with seasonal allergic rhinoconjunctivitis: Comparison to adult patients.

Background: Mounting evidence supports the efficacy of sublingual immunotherapy (SLIT) due to its favorable safety profile and convenience. However, there is limited research comparing the efficacy and safety of SLIT between adults and children.

Objective: The aim of this prospective study is to contribute additional corroborative findings by evaluating the efficacy and safety of a SLIT vaccine formulated with extracts in children and adult patients with seasonal allergic rhinoconjunctivitis (SARC).

Personalized risk score prediction and testing policy adaptations of a COVID-19 population-based contact tracing network.

Contact tracing is an effective public health policy to put the fast-spreading epidemic under control. The government tracks the contacts of confirmed SARS-CoV-2 cases, recommends testing, encourages self-quarantine, and monitors symptoms of contacts. In developing and less-developed countries with limited resources for widespread SARS-CoV-2 testing, it remains essential to identify and quarantine positive contacts to control outbreaks.

Autoimmune polyglandular syndrome among Chinese celiac disease patients: a survey of 243 individuals in China.

Background: Celiac disease (CeD), an autoimmune enteropathy, is often associated with multiple glandular autoimmune diseases. However, the prevalence and staging characteristics of autoimmune polyglandular syndrome (APS) among CeD patients remain unclear. The aim of this study was to assess the prevalence and clinical features of APS among Chinese CeD patients.

Migration of a ventriculoperitoneal shunt to the mediastinum: A case report and literature review.

Rationale: Ventriculoperitoneal shunt (VPS) surgery, a common neurosurgical procedure for hydrocephalus, carries risks of complications such as shunt obstruction and infection. Migration of the shunt into the mediastinum, however, is an uncommon complication, particularly in adults.

Patient Concerns: A 56-year-old male patient was admitted to our hospital with a complaint of "progressive decline in mobility over 3 months, significantly impairing daily activities.

Numerical study on the effect of pile shape and loading direction on the lateral response of displacement pile in sand.

Several finite element numerical simulations were conducted on laterally loaded piles in Geba sand to investigate how pile shape, loading direction, and pile length impact lateral load transfer curves and pile-soil interaction. The stress-strain behavior of Geba sand was defined using the hypoplastic constitutive model within the finite element software via the UMAT subroutine. The accuracy of the finite element model was confirmed through a comparison with the centrifuge test findings from prior research.

Determining the optimal surgical margin using whole scene pathology and molecular surgical margin analysis in colorectal cancer radical surgery-a cross-sectional study.

Background: An inadequate surgical margin is the major reason for disease recurrence; however, tumor recurrence sometimes even occurs in patients with pathologically negative surgical margins. The aim of this study is to determine the ideal surgical margin in radical colorectal cancer (CRC) surgery using panoramic pathology coupled with a molecular surgical margin (MSM) analysis.

Methods: The surgical specimens and clinical data of 194 CRC patients at the Guangxi Medical University Cancer Hospital from January 2016 to December 2019 were collected.

Does pay for performance affect socioeconomic inequalities in access? Evidence from hospital specialised care in England.

Pay for performance aims to improve quality and efficiency in the health sector but may widen inequalities. We investigate how pay for performance for specialised hospital care in England affected socioeconomic inequalities in access. We focus on two clinical areas: trauma care aimed at reducing delayed discharges from adult critical care; and internal medicine aimed at reducing in-hospital waiting time and length of stay for patients requiring urgent coronary bypass grafting.

Monitoring Nasal Breathing Using an Adjustable FBG Sensing Unit.

We have developed an adjustable optical fiber Bragg grating (FBG) sensing unit for monitoring nasal breathing. The FBG sensing unit can accommodate individuals with varying facial dimensions by adjusting the connecting holes of the ear hangers. We employed two FBG configurations: an encapsulated FBG within a silicon tube (FBG) and a bare FBG (FBG).

[Clinical Analysis of Primary Cutaneous CD8 Aggressive Epidermotropic Cytotoxic T-Cell Lymphoma].

Objective: To report the clinical characteristics, diagnosis, treatment and prognosis of one patient with primary cutaneous CD8 aggressive epidermotropic cytotoxic T-cell lymphoma (CD8 PCAECTL), and to strengthen the understanding of this extremely rare type of lymphoma.

Methods: The clinical manifestations, diagnosis, treatment course, and prognosis of one patient with CD8 PCAECTL admitted to our hospital were retrospectively analyzed.

Results: The patient is a 42-year-old female, with infiltrative skin rash on naso-facial and back as the main clinical manifestations.

Enhanced Ising Superconductivity and Emergent Ferromagnetism Coexisting in Bimolecule-Intercalated Bulk TaS.

Superconductivity and ferromagnetism are mutually exclusive in most cases. Here the observation of Ising superconductivity and ferromagnetism coexisting is reported in a bimolecule (tetrabutylammonium chloride and dimethylformamide, or TBAC/DMF)-intercalated bulk TaS, with the exotic phenomenon of quantum Griffiths singularity. It is first shown that the neighboring TaS layers are separated by 14.

Correlation of VEGF, HIF-1α, and MMP2 expression in placental villi among patients with recurrent spontaneous abortion.

Objective: In this study, the expression and clinical significance of vascular endothelial growth factor (VEGF), hypoxia inducible factor-1α (HIF-1α), and matrix metalloproteinase-2 (MMP2) in the placental villi of patients experiencing recurrent spontaneous abortion were investigated.

Methods: Fifty-one patients with recurrent spontaneous abortion (RSA) and 50 control individuals were enrolled (between January 2022 and December 2023). The mRNA and protein levels of VEGF, HIF-1α, and MMP2 in the placental villi of all enrolled patients were assessed using quantitative real-time polymerase chain reaction and western blot techniques.