Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy.

Psoriasis is a persistent inflammatory dermatological condition, predominantly influenced by genetic factors, immune system dysfunction, and environmental stimuli. It presents as red papules and silvery-white scales, resulting in physical discomfort and contributing to various comorbidities, including mental health disorders, arthritis, and cardiovascular complications, which collectively impose considerable medical and socioeconomic burdens. Conventional treatments, such as immunosuppressants and biologics, may alleviate symptoms but frequently entail significant side effects and the potential for dependency.

Effects of LIPOSA-T pharmacopuncture on localized fat as a fat dissolving injection via regulation of fat metabolism.

Background: Excessive fat deposition in localized adiposity is known to induce severe medical diseases as well as aesthetic problems. Of late, LIPOSA-T pharmacopuncture, a new herbal pharmacopuncture consisting of the cortex of and bark of , is developed as a non-surgical injection for dissolving localized fat deposits.

Methods: The network pharmacology analysis was carried out with the target gene sets of constituents of and .

Experimental effects of multi-dance sport training on student performance: a dual analysis of physical fitness and aesthetic skill development.

Introduction: This study addresses growing concerns about declining physical fitness and insufficient aesthetic literacy among university students. These issues are compounded by the limitations of traditional physical education in supporting holistic development. Dance-based interventions are proposed as a potential solution to bridge this gap.

Effect of an Ankle Stabilization Strap Using a Badaging Technique on Ankle Range of Motion, Balance, and Spatiotemporal Gait Parameters in Patients with Chronic Stroke: A Randomized Controlled Trial.

Background: Elastic ankle straps are frequently used to improve ankle stability; however, they often fail to provide adequate support due to material limitations. Therefore, this study aimed to investigate the effects of an ankle stabilization strap applied using a bandaging technique on ankle range of motion, balance, and spatiotemporal gait parameters in patients with chronic stroke.

Methods: Twenty-eight patients with chronic stroke were randomly assigned to either an ankle stabilization strap with bandaging technique (ASB, n = 14) group or an ankle-foot orthosis (AFO, n = 14) group.

Research trends in generative artificial intelligence in nursing: a scoping review.

Purpose: Generative artificial intelligence (AI) has yet to be comprehensively analyzed in the nursing literature. This study aimed to identify research trends in generative AI within the nursing field through a scoping review and propose strategies for its effective utilization in nursing.

Methods: A scoping review was conducted following Arksey and O'Malley's six-stage framework.

Efficacy and safety of steamed ginger extract for gastric health: a randomized, double-blind, placebo-controlled multi-center clinical trial.

The aim of this study was to investigate the efficacy and safety of steamed ginger extract (GGE03) for mild to moderate functional dyspepsia (FD) in a 12-week randomized, double-blind, placebo-controlled clinical trial. A total of 80 subjects who met the inclusion criteria without meeting the exclusion criteria were randomly assigned to a GGE03 group ( = 40, 480 mg day as GGE03) or a placebo group ( = 40). Efficacy and safety evaluations were conducted before intervention and at 12 weeks after intervention.

Differences in the relationship among grit, self-regulation, competition preparation, and sport confidence across performance levels: a multi-group analysis.

In the literature on high-competition sports, some evidence has been suggested regarding the relationships between athletes' grit, self-regulation, competition preparation, and confidence. However, there has been a lack of integrated approaches to examine the relationships among these variables, and the performance level of athletes have not been considered. Therefore, this study (a) analyzed the structural relationships between grit, self-regulation, competition preparation, and confidence, and (b) investigated how these relationships vary according to athletes' performance levels.

Integrating analytical quality by design into bioanalytical method development: an HPLC-FLD method for quantification of alectinib in biological matrix.

This study presents the development and validation of a fluorescence-based high-performance liquid chromatography (HPLC) method for the quantification of alectinib in rat plasma, with a focus on the application of Analytical Quality by Design (AQbD) to bioanalytical method development. Unlike conventional QbD applications, which primarily address synthetic formulations or instrumental settings, this study systematically applied AQbD principles to the complex environment of biological matrices. Critical method parameters, including the organic phase ratio, buffer concentration, and flow rate, were identified through Failure Mode and Effects Analysis, and optimized using a Box-Behnken design.

A Case Report on Home-Based End-of-Life Care with Traditional Korean Medicine Acupuncture and Herbal Medicine for an Elderly Patient with Parkinson's Disease.

Managing multiple symptoms in home-based palliative care (HBPC) is challenging. Acupuncture and herbal medicine have been widely used to alleviate symptoms in patients with cancer receiving palliative care, but their role in HBPC for nonmalignant diseases such as Parkinson's disease (PD) remains underexplored. We report the case of an 86-year-old woman with end-stage PD who received HBPC.

Immuno-metabolic diseases and therapeutics: molecular mechanisms via inflammasome signaling.

Inflammatory responses serve as essential defense mechanisms in living organisms, but persistent or excessive activation can contribute to the development of chronic metabolic diseases. A central regulator of such inflammation is the inflammasome, a cytosolic multiprotein complex that senses pathogenic or stress-related signals and triggers the maturation of pro-inflammatory cytokines, particularly interleukin-1β (IL-1β) and interleukin-18 (IL-18). While inflammasome-induced pyroptosis, a form of lytic cell death, can play protective roles in pathogen clearance, excessive or dysregulated activation is more commonly associated with chronic inflammation and tissue damage.

The relationship between parenting style and bystander's promotion of cyberbullying among college students: the mediating effect of neuroticism and moral disengagement.

To explore the relationship between parenting style and bystander's promotion of cyberbullying among Chinese college students, as well as the mediating effect of neuroticism and moral disengagement. A total of 495 college students were selected as participants in this study. The short form Egna Minnen av.

Time-Restricted Eating Improves Glycemic Control in Patients with Type 2 Diabetes: A Meta-Analysis and Systematic Review.

Time-restricted eating (TRE), a dietary strategy that aligns food intake with circadian rhythms, has emerged as a promising non-pharmacological approach for improving glycemic control in patients with type 2 diabetes. This systematic review and meta-analysis evaluated the effects of TRE on glycemic outcomes by analyzing eight randomized controlled trials involving 312 participants with type 2 diabetes or impaired fasting glucose. Meta-analyses of six eligible studies demonstrated that TRE significantly reduced fasting glucose (mean difference [MD]: -0.

Effects of Red Mud on Cement Mortar Based on Sodium Salt Type.

This study treated the NaOH component in red mud sludge, an industrial by-product generated at 300,000 tons annually in Korea, with sulfuric and nitric acids to produce NaSO and NaNO, respectively. The effects of acid-treated liquid red mud (LRM) on the hydration reactions and early strength development in cement mortar were investigated. Properties such as flow, setting time, hydration heat, and compressive strength were evaluated alongside hydration product analysis using X-ray diffraction (XRD) and scanning electron microscopy (SEM).

Comparative advantage and efficacy of natural products for polycystic ovary syndrome.

Background: Natural products including Korean Medicine, Traditional Chinese Medicine and Campo medicine have been suggested to be suitable for polycystic ovary syndrome (PCOS), which is known to be a multifactorial disease, since current treatment for PCOS focuses on the amelioration of symptoms with adverse effects.

Aim Of The Study: In this review, the ethnopharmacology and mechanisms of natural remedies including herbs, herbal formulation and acupunctures are introduced, providing a comprehensive insight for its advantage on PCOS.

Materials And Methods: We conducted a comprehensive literature search using PubMed, MEDLINE, and Google Scholar databases.

Effectiveness of Inhalation of a New Essential Oil Formulation on Asthma Through Network Pharmacology and In Vivo Analysis.

Asthma is one of the chronic inflammatory disorders with shortness of breath, chest tightness, wheezing, and coughing. Considering that essential oils from aromatic plants have been widely used for relieving inflammatory diseases, the protective effects and molecular mechanisms of the inhalation of the essential oil formulation derived from L., Miq.

Inhibition of breast cancer resistance protein by flavonols: in vitro, in vivo, and in silico implications of the interactions.

Breast cancer resistance protein (BCRP), a member of the ATP-binding cassette transporter family, plays a key role in the efflux of various drugs and is linked to multidrug resistance in cancer therapy. Flavonoids, particularly those with a flavonol backbone, have shown promise as inhibitors of BCRP activity; however, their specific inhibitory effects are not fully understood. This study explored the inhibitory effects of 77 flavonols on BCRP and identified 22 compounds with significant inhibitory activity.

Problematic smartphone use and risk behaviors in adolescents during the COVID-19 pandemic.

Background: This study examined the association between problematic smartphone use (PSU) and risk behaviors among Korean adolescents during the COVID-19 pandemic. It also aimed to develop preventive measures for adolescent health promotion in the event of future pandemics.

Methods: A secondary analysis of data from the 16th Korean Youth Risk Behavior Web-based Survey (2020) was conducted, which included 54,948 middle and high school students.

Excessive intake of fructose and alcohol aggravates high-fat diet-induced steatohepatitis and changes hepatic iron homeostasis.

Hepatocytes play a vital role in maintaining iron homeostasis, which can be compromised by poor diet and lifestyle. This study aimed to assess the combined impact of high-fat diet (HFD), alcohol, and fructose intake on liver injury and iron metabolism. Male Sprague-Dawley rats (5‒7 weeks old, weighing 160‒180 g) were randomly assigned to three groups: regular chow, HFD, and a combined HFD with 30% ethanol and 30% fructose (HF‒EFr), and were maintained for 4 or 8 weeks.

Quantification of Total and Unbound Selinexor Concentrations in Human Plasma by a Fully Validated Liquid Chromatography-Tandem Mass Spectrometry Method.

Selinexor is a selective nuclear-export inhibitor approved for hematologic malignancies, characterized by extensive plasma protein binding (>95%). However, a validated analytical method to accurately measure the clinically relevant unbound fraction of selinexor in human plasma has not yet been established. This study aimed to develop a fully validated bioanalytical assay for simultaneous quantification of total and unbound selinexor concentrations in human plasma.

A Study on the Diagnosis of Lumbar Spinal Malposition in Chuna Manual Therapy Using X-Ray Images Based on Digital Markers.

This study aimed to evaluate digital markers and establish quantitative diagnostic criteria for spinal malpositions in Chuna manual therapy using lumbar X-rays. A total of 2000 X-ray images were collected from adult patients at the International St. Mary's Hospital of Catholic Kwandong University.

Iatrogenic lung overinflation resulting in pneumothorax and pneumoperitoneum during oxygen therapy after general anesthesia: A case report.

Rationale: Oxygen therapy is a critical component of postoperative care, particularly after general anesthesia. Although generally safe, its improper administration can lead to serious complications. This report details an incident of lung overinflation during postoperative oxygen therapy that resulted in pneumothorax and pneumoperitoneum.

The complete mitochondrial genome of sand anemone, (Wassilieff, 1908).

This study reports the complete mitochondrial genome of (Actiniidae) for the first time. The mitogenome is 19,880 bp in length and contains 17 annotated genes, including 13 protein-coding genes, one nonconventional mitochondrial protein gene (ORF), two ribosomal RNA genes, and two transfer RNA genes. The gene content, order, and genome length are consistent with those of other sea anemones.

Species-specific gene regulatory network rewiring mediated by the GATA-type regulator NsdD in .

The evolutionarily conserved GATA-type transcription factor (TF) NsdD regulates sexual and asexual development as well as secondary metabolism in various species. Despite its well-known multifunctionality, the mechanisms by which NsdD coordinates such diverse biological processes remain unclear. To address this gap, we have conducted network-based multiomics analyses in two distantly related species, and .

Evaluation study on gas-phase passivation inhibiting the spontaneous combustion tendency of ferrous sulfide compounds.

The iron sulfide compound FeS, present in petrochemical plants, is prone to spontaneous combustion when exposed to air, posing a significant threat to the safety of production processes in the petrochemical industry. Accurately assessing the spontaneous combustion tendency of FeS is crucial for preventing fire and explosion hazards in petrochemical storage tanks. In this study, FeS was passivated with 3%, 6%, and 9% concentrations of passivator for 2 to 8 h, and the effects of gas-phase passivation on FeS were investigated.

Mechanisms of the impact of exercise intervention on college students' mental health: a longitudinal experimental study using swimming as an example.

Introduction: With the growing prevalence of mental health issues among college students, there is a pressing need for effective and accessible intervention strategies. This study explores the potential of swimming as a structured intervention to improve students' emotional well-being, social adaptation, and academic stress management.

Methods: A 15-week swimming intervention program was implemented among 44 college students, who were randomly assigned to either an experimental group (swimming intervention) or a control group (no intervention).