Current Therapeutic Strategies in Parkinson's Disease: Future Perspectives.

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons and the accumulation of misfolded α-synuclein. Current treatments, including dopaminergic medications and deep brain stimulation (DBS), provide symptomatic relief but do not halt disease progression. Recent advances in molecular research have enabled the development of disease-modifying strategies targeting key pathogenic mechanisms, such as α-synuclein aggregation, mitochondrial dysfunction, and genetic mutations including LRRK2 and GBA1.

PDGFR mediates lumbar spinal stenosis-induced neuropathic pain by regulating JAK2/STAT3 signaling in activated macrophages.

Lumbar spinal stenosis (LSS) is one of the most common spinal disorders in elderly people and is often accompanied by neuropathic pain. Although our previous studies have demonstrated that infiltrating macrophage contribute to chronic neuropathic pain in LSS rat model, the molecular mechanisms underlying macrophage activation and infiltration have not been fully elucidated. In this study, we examined the critical role of platelet-derived growth factor receptor (PDGFR) signaling pathway in neuropathic pain associated with macrophage infiltration and activation in LSS rats.

Activity and access of surgical abortion in metropolitan France.

Objective: To report the territorial distribution and characteristics of healthcare centres performing surgical abortion in France, along with the accessibility of these centres.

Material And Methods: A nationwide population-based cohort study of all women hospitalized for surgical abortion was conducted from January 1 to December 31, 2022 in metropolitan France. Number, location, activity volume and use of local anaesthesia rate of surgical abortion centres were reported as distribution activity across metropolitan France.

Unveiling NiO/Perovskite Interfaces: Charge Transport and Device Performance in Perovskite Solar Cells.

NiO is a p-type semiconductor widely used as a hole transport material in perovskite solar cells (PSCs), yet the impact of fabrication methods on its interfacial properties and the underlying mechanisms remains unclear. This study investigates how the fabrication process─nanoparticle precursor (NP NiO) and sputtering deposition (SP NiO)─and interfacial space charge effects influence charge transport and device performance in NiO/perovskite systems. SP NiO exhibits a higher Ni/Ni ratio and greater conductivity but induces significant hole depletion and band bending at the interface, leading to reduced open-circuit voltage and efficiency.

Association between residential greenness and allergic diseases among adolescents in South Korea: A nationwide representative study.

Background: Residential greenness is an important environmental factor potentially influencing the development of allergic diseases in adolescents; however, its impact remains understudied in South Korea. This study aimed to examine the association between residential greenness and allergic disease prevalence using nationally representative data.

Method: We analyzed data from 1,130,598 adolescents (7-12th grade) participating in the Korean Youth Risk Behavior Web-based Survey (2007-2024).

Fluorescence-guided tumor resection with a cathepsin B-activatable, EGFR-targeted probe and a dual-mode surgical exoscope.

Fluorescence-guided surgery enhances surgical precision by enabling real-time tumor visualization. Here, we developed a cathepsin B-activatable imaging probe conjugated to the EGFR-targeting antibody cetuximab (Cetux-CB probe) for fluorescence-guided resection of triple-negative breast cancer (TNBC). The probe consists of a cathepsin B-sensitive peptide linker, a near-infrared fluorophore (Flamma™ Fluors 749), and a quencher (qFlamma Black01), enabling enzymatic activation following tumor-specific accumulation.

Heterostructure nanodisks for multicolor polariton lasers with controllable whispering-gallery modes.

Highly efficient optoelectronic devices of ultrasmall sizes are demanded as building blocks of next-generation integrated circuits, where tunable color enhances the feasibility of various applications. Here, we realize tunable multicolor nanolasers using disk-shaped axial heterostructures composed of III-nitride materials (GaN/InGaN/GaN), leveraging the optical confinement effect and active waveguiding. In heterostructure nanodisks, the development of exciton-polariton induces unique features near the resonance regime, and the formation of whispering-gallery modes facilitates optical gain processes for the polaritonic lasing of GaN.

Effects of high-intensity low-volume vs. low-intensity high-volume plyometric jump training on athletic performance in taekwondo athletes: randomized trial.

Background: This study aims to determine the effects of high-intensity low-volume (HILV) versus low-intensity high-volume (LIHV) plyometric jump training on athletic performance in Taekwondo athletes.

Methods: Seventeen Taekwondo athletes (age: 19.35±1.

Prognostic Value of A/T/N Biomarkers: Comparing Plasma and Imaging Modalities in Alzheimer Disease.

Background: Alzheimer disease (AD) is characterized by amyloid-β plaques (A), tau tangles (T), and neurodegeneration (N), collectively defining the ATN framework. While imaging biomarkers are well-established, the prognostic value of plasma biomarkers in predicting cognitive decline remains underexplored. This study compares plasma and imaging A/T/N biomarkers in predicting cognitive decline and evaluate the impact of combining biomarkers across modalities.

Correlation between the immune response to COVID-19 vaccines and the constitutions of traditional Chinese medicine.

Traditional Chinese Medicine (TCM) classifies individuals into constitution types that may influence physiological responses. SARS-CoV-2 vaccines induce spike-specific antibodies and activate B and T cells, including memory subsets. This study investigates whether TCM constitution types are associated with immune responses and adverse events following COVID-19 vaccination.

Comprehensive Dentition Intrusion in Hyperdivergent Patients Using Temporary Skeletal Anchorage Devices.

Hyperdivergent skeletal Class II malocclusion is largely genetically determined and poses significant challenges in orthodontic treatment, particularly due to compromised facial aesthetics, reduced bite force and airway narrowing. Traditionally, orthognathic surgery has been the standard treatment for correcting such skeletal discrepancies. However, the advent of temporary skeletal anchorage devices (TSADs) has expanded the possibilities for orthodontic camouflage by allowing effective vertical control.

An Integrative Analysis of Psychological Mechanisms Underlying the Effects of Online and Social Media Exposure on Drought Mitigation-Related Outcomes.

Climate change is an urgent environmental risk. This study examines an integrative model suggesting psychological pathways from drought-related information exposure through online and social media to drought mitigation behavioral intentions and support for drought management policies. The model proposes links between these variables through perceived risks, fear, anger, and hope, with institutional trust acting as a moderator.

Socioeconomic factors affecting breast and cervical cancer screening compliance in Asian National Cancer Centers Alliance countries: a systematic review.

Objectives: Breast and cervical cancers are the most frequently diagnosed cancers in women. The Asian National Cancer Centers Alliance (ANCCA) has strengthened cancer control efforts in the Asia region; however, only a few countries have achieved sufficient participation rates. This systematic review aimed to synthesize the existing evidence on socioeconomic factors influencing women's compliance with breast and cervical cancer screening in ANCCA countries.

Public perception and changing attitudes toward antidepressants over a decade in social media: Lessons learned from online discussion using artificial intelligence.

Background: Antidepressants play a crucial role in treating mental health disorders such as depression and anxiety. Understanding of patients' perspective on antidepressants is essential for improving treatment outcomes; however, year-to-year change in the public's perception of antidepressants remains unclear. We aimed to analyze changes in public sentiments and predominant perceptions regarding antidepressants using artificial intelligence pipeline.

Fe-N@Graphene Single-Atom Catalyst-Based Nanozyme against Influenza A Virus.

Recent COVID-19 pandemic has raised an urgent need for effective strategies to combat viruses that can pose serious health threats to the entire human race. Incorporating antipathogenic functions into everyday objects and personal protective equipment has become increasingly important, motivating the development of general-purpose antiviral materials. Single-atom catalysts, known for superior catalytic performance and maximized atomic utilization, have been explored in various research fields, including artificial nanozymes for bioapplications.

Engaging Fathers in Child Nutrition: Exploring Intra-household Gender Dynamics in Nutrition Interventions in Ethiopia.

This study aims to examine intra-household gender dynamics in response to a nutrition intervention (maternal Behaviour Change Communication (BCC), paternal BCC, and food vouchers) aimed at improving IYCF practices using qualitative methods. Participants were drawn from a subset of households enrolled in a larger cluster - randomized controlled trial (RCT) conducted in rural Ethiopia. A total of 40 participants (20 mother-father pairs) from intervention and control households were interviewed separately to explore intra-dyadic beliefs and household decision-making.

Impact of nurses' health beliefs about caring for older adults on their own preparation for old age.

Background: The older adults is increasing worldwide, and South Korea in particular is experiencing a rapid increase in the older adults. In this situation, related research targeting nurses who care for the older adult is necessary.

Objective: This study was to examine the relationships among preparation for old age and health beliefs, and the factors influencing preparation for old age of young nurses in their 20s and 30s who care for older adults in general hospitals.

Rigid cationic ligands enable high-efficiency NIR-II photoluminescence in copper(i) iodide hybrid semiconductors.

Near-infrared (NIR) luminescent materials are pivotal for advanced optoelectronic and biomedical applications, yet attaining efficient emission in the NIR-II region (950-1400 nm) remains challenging. Here, we introduce a ligand cationization strategy for designing copper(i) iodide-organic hybrid materials that emit in the NIR-II region (920-1120 nm) with PLQYs up to 8.58%.

Characteristics and management of mechanically ventilated patients in South Korea compared with other high-income Asian countries and regions.

Background: This study investigated the characteristics of mechanically ventilated patients in South Korean intensive care units (ICUs).

Methods: We conducted a subgroup analysis of a multinational observational study. Data from 271 mechanically ventilated patients in South Korean ICUs were analyzed for demographics, ventilation practices, and mortality, and were compared with those of 327 patients from other high-income Asian countries.

Immediate versus staged complete revascularisation during index admission in patients with ST-segment elevation myocardial infarction and multivessel disease (OPTION-STEMI): a multicentre, non-inferiority, open-label, randomised trial.

Background: The optimal timing of complete revascularisation for patients with ST-segment elevation myocardial infarction (STEMI) and multivessel coronary artery disease remains unclear. We aimed to assess whether immediate complete revascularisation was non-inferior to staged complete revascularisation during the index admission.

Methods: We conducted an open-label, randomised, non-inferiority trial at 14 hospitals in South Korea.

Anti-Obesity Effects of Extracts via the AMPK Signaling Pathway in 3T3-L1 Adipocytes.

Obesity is a major public health concern because of its association with metabolic disorders (e.g., type 2 diabetes mellitus) and cardiovascular diseases.

The role of high-risk plaque in refining cardiovascular event prediction.

Purpose Of Review: High-risk plaque (HRP) features are commonly observed in patients with acute coronary syndromes (ACS); however, their individual predictive value remains limited. This review explores the importance of integrating anatomical and physiological assessments to enhance risk stratification and optimize therapeutic decision-making.

Recent Findings: Studies have indicated that combining HRP evaluation with hemodynamic assessment significantly improves prognostic accuracy, particularly in guiding revascularization strategies.

Comparison of a Single Treatment of Needleless Microsubcision With Hyaluronic Acid and Carbon Dioxide Pinhole Method for Atrophic Acne Scars.

Background: Scarring, particularly the atrophic type, is one of the most distressing consequences of acne. Despite the availability of various treatment options, no single best treatment option has been recognized.

Objective: To compare the efficacy of carbon dioxide (CO2) pinhole method and needleless microsubcision with hyaluronic acid (HA) to identify a more effective treatment option for acne atrophic scars.

Toward Nutrient-Rich Rice: Biofortification through Mineral Accumulation and Low Phytic Acid Content.

Nicotianamine synthases regulate the biosynthesis of two mineral chelators key for rice grain biofortification, nicotianamine (NA) and 2'-deoxymugineic acid (DMA). We produced transgenic rice expressing under the promoter () and mutated in these () and the wild-type () to enhance essential mineral accumulation in grains while lowering phytic acid (PA) levels. NA and DMA contents were higher in the brown grains of , , and plants.