Heterostructure nanodisks for multicolor polariton lasers with controllable whispering-gallery modes.

Highly efficient optoelectronic devices of ultrasmall sizes are demanded as building blocks of next-generation integrated circuits, where tunable color enhances the feasibility of various applications. Here, we realize tunable multicolor nanolasers using disk-shaped axial heterostructures composed of III-nitride materials (GaN/InGaN/GaN), leveraging the optical confinement effect and active waveguiding. In heterostructure nanodisks, the development of exciton-polariton induces unique features near the resonance regime, and the formation of whispering-gallery modes facilitates optical gain processes for the polaritonic lasing of GaN.

Distinctive optical transitions of tunable multicolor carbon dots.

Three types of carbon dots (CDs) are synthesized from isomers of phenylenediamine to develop multicolor nanomaterials with low toxicity, high stability, and high quantum yield. The distinctive electronic structures of CDs lead to the characteristic optical transitions, such as three colors of blue, green, and red, which are primarily attributed to the difference in configurations, despite the similar basic structures of conjugated systems. The excitation-independent emission and the single exponential decay of CDs indicate the single chromophore-like nature in each type of CD.

Discovery of novel DUSP16 phosphatase inhibitors through virtual screening with homology modeled protein structure.

Recently, dual-specificity phosphatase 16 (DUSP16) emerged as a promising therapeutic target protein for the development of anti-atherosclerosis and anticancer medicines. The present study was undertaken to identify the novel inhibitors of DUSP16 based on the structure-based virtual screening. We have been able to find seven novel inhibitors of DUSP16 through the drug design protocol involving homology modeling of the target protein, docking simulations between DUSP16 and its putative inhibitors with the modified scoring function, and in vitro enzyme assay.

Directional disorder of ciliary metachronal waves using two-dimensional correlation map.

The interrelationship of cilia and the order of wave directions are important factors that determine the effectiveness of cilia to transport materials in mucociliary systems of the respiratory tract. The interrelationship of cilia and the directional disorder of ciliary metachronal wave were analyzed using digital microscopic images. The degree of synchronization between ciliary beats was determined by the correlation factor between two different spots.