The Indo-European Cognate Relationships dataset.

The Indo-European Cognate Relationships (IE-CoR) dataset is an open-access relational dataset showing how related, inherited words ('cognates') pattern across 160 languages of the Indo-European family. IE-CoR is intended as a benchmark dataset for computational research into the evolution of the Indo-European languages. It is structured around 170 reference meanings in core lexicon, and contains 25731 lexeme entries, analysed into 4981 cognate sets.

Understanding the link between adolescent depression and precarious employment in adulthood: evidence from a sibling fixed effects analysis.

Background: Adolescent depressive symptoms may mark the beginning of long-term trajectories of socioeconomic disadvantage, yet their role in shaping labor market outcomes remains understudied. This study investigates the longitudinal association between depressive symptoms in adolescence and precarious employment in adulthood and explores the mediating roles of persistent depressive symptoms and educational attainment.

Methods: Using a sample of 3,703 individuals from full sibling pairs in the National Longitudinal Study of Adolescent to Adult Health, we employed sibling fixed effects models to control for unobserved family-level confounding.

Debt Strain and Child Protective Services Involvement.

Research has identified a likely causal relation of economic precarity with both child maltreatment and child protective service (CPS) involvement. Yet, little is known about the relation between credit use (debt) and CPS involvement despite credit becoming an increasingly normative aspect of attempting to manage economic precarity for low-income families. We link individual-level longitudinal data on credit use to administrative records on CPS involvement, to examine whether credit related economic precarity-or 'debt strain'-is associated with increased CPS reports, allegations of child neglect and child abuse, and CPS removal of children for low-income mothers in Wisconsin from 2016-2021.

From the patient point of view: Using eye tracking to evaluate older adult shopping behavior change with a community pharmacy OTC intervention.

Background: Over-the-counter medications are an integral component of community pharmacies, providing patients with accessible options for addressing health concerns independently. However, this increases the potential for adverse drug events, particularly among older adults, due to overestimating medication safety. Pharmacy layouts, often informed by retail store principles, frequently prioritize product profitability over patient safety.

Cherenkov Imaged Bio-Morphological Features Verify Patient Positioning With Deformable Tissue Translocation in Breast Radiation Therapy.

Purpose: Accurate patient positioning is crucial for precise radiation therapy dose delivery, as errors in positioning can profoundly influence treatment outcomes. This study introduces a novel application for loco-regional tissue deformation tracking via Cherenkov image analysis during fractionated breast cancer radiation therapy. The primary objective of this research was to develop and test an algorithmic method for Cherenkov-based position accuracy quantification, particularly for loco-regional deformations, which do not have an ideal method for quantification during radiation therapy.

Comparative analysis of cranberry fruit rot fungal diversity in Massachusetts from wild, organic, and conventional ecosystems using multiplex PCR.

Cranberry fruit rot (CFR) has been a major challenge in cranberry production affecting fruit quality, particularly in Massachusetts and New Jersey. It is known to be a disease complex associated with several diverse fungi. This study provides the first comprehensive assessment of CFR fungal population dynamics across wild, organic, and conventional cranberry production systems in southeastern Massachusetts.

Let's Talk About Sex: An Acceptable, Appropriate and Feasible Online Sexual Health Educational Video Series for Breast Cancer Patients.

Purpose: Sexual health-related side effects during breast cancer treatment are common and distressing but not always expected by patients. We created an online sexual health educational video series to increase patients' awareness of these issues. In this exploratory study, we aimed to evaluate the acceptability, appropriateness, and feasibility of the video series among newly diagnosed breast cancer patients.

Feasibility of expiratory muscle strength training to address oropharyngeal dysphagia in a patient living with mixed dementia: A case report.

Oropharyngeal dysphagia frequently occurs in persons living with Alzheimer's disease and related dementias (PLWD) and results in negative health consequences. Strength-based exercises may address swallowing biomechanical impairments. Expiratory muscle strength training (EMST) is an intervention examined in other neurodegenerative populations and has demonstrated promise for improving respiratory muscle strength and airway defense physiologic capacity, potentially improving swallowing safety.

Caregiver-Implemented AAC Interventions for Children with Intellectual or Developmental Disabilities: a Systematic Review.

Many children with intellectual and/or developmental disabilities benefit from augmentative and alternative communication strategies (AAC) to increase their communicative competency. Furthermore, caregiver-implemented AAC interventions are an effective and efficient strategy to improve communication outcomes. We reviewed the caregiver-implemented AAC intervention literature to assess child and caregiver characteristics, what kind of interventions caregivers were taught, how caregivers were trained, and how studies evaluated caregiver implementation.

Object Functions and Words Reexamined: Toddlers' Recognition of Function Depends on Object Type.

The role of function in toddlers' object labeling has been debated for decades in developmental science. We aimed to clarify the relation between toddlers' understanding of functions and words using a set of everyday objects that varied in the number of associated functions (e.g.

Advances in immunoPET/SPECT imaging: The role of Fab and F(ab') fragments in theranostics.

With the advent of precision medicine and personalized treatment, targeted therapies have become pivotal in oncology. Noninvasive molecular imaging, especially immunoPET/SPECT, plays a crucial role in refining cancer diagnostics and treatment monitoring by visualizing biological processes at the molecular level. This review explores the dynamic field of immunoPET/SPECT imaging using Fab and F(ab') fragments, characterized by advantageous pharmacokinetics and swift clearance from the bloodstream, making them suitable for same-day imaging procedures.

Investigating Macular Tissue Integrity Index as a Novel Biomarker in Geographic Atrophy.

Purpose: The rate of geographic atrophy (GA) enlargement is commonly used as an outcome in clinical trials. However, this metric typically lacks specificity for central macular involvement and structure-function relationships. We propose a targeted approach in monitoring GA progression within the central macula, highlighting the limited benefit of including GA expansion beyond the 3-mm perifoveal zone when analyzing visual function.

Development and usability testing of an online platform for provider training and implementation of cognitive-behavioral therapy guided self-help for eating disorders.

Background: Most individuals with eating disorders (EDs) do not receive treatment, and those who do receive care typically do not receive evidence-based treatment, partly due to lack of accessible provider training. This study developed a novel "all-in-one" online platform for disseminating training for mental health providers in cognitive-behavioral therapy guided self-help (CBTgsh) for EDs and supporting its implementation. The aim of the study was to obtain usability data from the online platform prior to evaluating its effects on provider training outcomes and patient ED symptom outcomes in an open pilot trial.

Subaerial oxidative uranium mobilization at the culmination of the Great Oxidation Event.

Redox-sensitive elements figure prominently in studies of the evolution of Earth's surface redox state, including the first major rise in atmospheric O, the Paleoproterozoic Great Oxidation Event. Most Precambrian rocks endured multistage tectonothermal histories, however, adding ambiguity to interpretation of their chemistry. Here, we apply U-Th-Pb isotope geochronology to the highly oxidized ~2.

Human papillomavirus genomes associate with active host chromatin during persistent viral infection.

Human papillomaviruses (HPVs) maintain their genomes as minichromosomes in the nuclei of infected keratinocytes. This study investigates the association of HPV31 genomes with host chromatin using both HiC and 4C-seq chromosome conformation capture techniques. We show that HPV31 genomes preferentially associate with transcriptionally active A compartments of host chromatin, regions of open chromatin defined by ATAC-seq, and super-enhancers defined by Brd4 and H3K27ac ChIP-seq.

Optimized motion-insensitive PDFF mapping of the liver.

Purpose: To implement, optimize, and validate parallel imaging (PI)-accelerated, 2D, flip angle modulated (FAM) chemical shift-encoded quantification of liver proton-density fat fraction (PDFF), with motion insensitivity.

Methods: The optimization cost function that determines flip angles in FAM was generalized for PI. Phantom studies and prospective studies in volunteers with varying liver fat levels were performed.

A Synergistic 3D-Printed Collar Transforms Radiofrequency Ablation Into Potent Thermal Immunotherapy for Lung Cancer.

Interventional thermal therapy, such as radiofrequency ablation (RFA), is a preferred therapy for non-small cell lung cancer (NSCLC) patients. However, part of some patients will still suffer from tumor recurrence due to incomplete ablation (e.g.

Ultrahigh pressure compaction-resistant thin film crosslinked composite reverse osmosis membranes.

In this study, we present a class of thin-film crosslinked (TFX) composite reverse osmosis (RO) membranes that resist physical compaction at ultrahigh pressures (up to 200 bar). Since RO membranes experience compaction at virtually all pressure ranges, the ability to resist compaction has widespread implications for RO membrane technology. The process described herein involves crosslinking a phase inverted porous polyimide (PI) support membrane followed by interfacial polymerization of a polyamide layer, thereby forming a fully thermoset composite membrane structure.

Isotope-encoded spatial biology identifies plaque-age-dependent maturation and synaptic loss in an Alzheimer's disease mouse model.

Understanding how amyloid beta (Aβ) plaques develop and lead to neurotoxicity in Alzheimer's disease remains a major challenge, particularly given the temporal delay and weak correlation between plaque deposition and cognitive decline. This study investigates how the evolving pathology of plaques affects the surrounding tissue, using a knock-in Aβ mouse model (App). We combined mass spectrometry imaging with stable isotope labeling to timestamp Aβ plaques from the moment of their initial deposition, enabling us to track their aging spatially.

Evidence for deliberate burial of the dead by .

In this study, we describe new results of excavations in the Dinaledi Subsystem of the Rising Star cave system, South Africa. In two areas within the Hill Antechamber and the Dinaledi Chamber, this work uncovered concentrations of abundant fossils including articulated, matrix-supported skeletal regions consistent with rapid covering by sediment prior to the decomposition of soft tissue. We additionally re-examine the spatial positioning of skeletal material and associated sediments within the Puzzle Box area, from which abundant remains representing a minimum of six individuals were recovered in 2013 and 2014.

Smooth muscle of the lower urinary tract: BK-RyR coupling in physiology and pathophysiology.

In the lower urinary tract, coordinated function between the bladder and urethra is essential for normal micturition, requiring smooth muscle contraction and relaxation in a tightly regulated cycle. During the bladder filling phase, the bladder remains relaxed while the urethra stays contracted to prevent leakage. During voiding, this coordination reverses, and the bladder contracts to expel urine while the relaxed urethra allows urine flow.

Sensor Fusion Algorithm to Improve Accuracy of Robotic Superposition Testing Using 6-DOF Position Sensors.

To quantify the contributions of specific ligaments to overall joint biomechanics, the principle of superposition has been used for nearly 30 years. This principle relies on a robotic test system to move a biological joint to the same pose before and after transecting a ligament. The difference in joint forces before and after transecting the ligament is assumed to be the transected ligament's tension.

Taxogenomic Analysis of a Novel Yeast Species, Lachancea rosae Sp. Nov. F.A., Isolated From the Wild Rose Rosa californica.

A novel Saccharomycotina yeast strain, yHQL494, was isolated from the rose hip of the wild rose Rosa californica from Castle Crags State Park, California, USA. Phylogenetic analyses of both whole genome data and the sequences from the D1/D2 region of the large ribosomal subunit (LSU) rRNA gene placed strain yHQL494 within the genus Lachancea and grouped it into a clade with Lachancea lanzarotensis and Lachancea meyersii. Taxogenomic analyses were conducted on publicly available genome sequences to gain a deeper insight into the carbon and nitrogen gene-trait associations across the Lachancea clade.