Multifunctional polyamidoxime-co-polyethyleneimine tailored cellulose derived from sustainable biomass for effective removal of acidic dye pollutants from wastewater.

Multifunctional polymers derived from waste biomass are under intense global investigation for wastewater remediation owing to their environmental advantages. Therefore, this study reports the synthesis of a novel polyamidoxime-co-polyethyleneimine multifunctional cellulose, which was used as an adsorbent for the removal of acidic dye pollutants. Morphological, structural, and surface studies were performed using several techniques.

Overview of evidence synthesis types and modes.

Background And Objectives: Evidence syntheses systematically compile and analyze information from multiple sources to support health care decision making. As many different types of questions need to be answered in health care, different evidence synthesis types have emerged. In this article, we introduce the most common types of evidence synthesis.

The Epstein-Barr Virus in Classical Hodgkin Lymphoma: Pathogenesis, Immunobiology, and Therapeutic Implications.

Classical Hodgkin lymphoma (cHL) is a unique B cell malignancy characterised by the presence of Hodgkin/Reed-Sternberg (HRS) cells within an extensive inflammatory microenvironment. In approximately 40% of cases- particularly in the mixed cellularity subtype-HRS cells are infected with the Epstein-Barr virus (EBV). EBV-positive cHL displays a restricted pattern of viral gene expression (latency II), with functional contributions from EBNA1, LMP1, and LMP2A/B, as well as some non-coding RNAs.

Stabilising large biologics through complimentary buffer component protection and rapid drying times.

High processing temperatures restrict spray drying applications for heat sensitive biologics. This work highlights the potential of Phosphate Buffer Saline (PBS) as the sole stabilising excipient when spray drying large biologics via a complimentary buffer component effect. Fibrinogen (∼340 kDa) was spray dried in PBS at various temperatures and concentrations, followed by assessment of the protein's structural integrity by UV-Vis, ATR-FTIR, SEM, and PXRD analyses.

Virtual Observation Units: A Novel Disposition for Older Adults With Falls From the Emergency Department.

Virtual observation units (VOUs) are being implemented across the country and serve as a model for patients to receive observational-level care at home. Falls are a leading cause of emergency department (ED) visits in the geriatric population and can cause substantial morbidity or mortality. Despite ED guidelines recommending fall-risk evaluation, the ED does not typically assess future fall risk given limited resources.

Discrete Actuation of Water-Responsive Crystalline Metal-Peptide Frameworks.

Engineering guest-responsive materials capable of controlled and precise sorption behavior and structural deformation in response to external stimuli is imperative for various applications. However, existing systems often exhibit complex, unpredictable dynamics, posing challenges for efficient control and utilization. Here, we design crystalline metal-peptide frameworks with tunable water-responsive (WR) dynamics by assembling glycine-threonine (Gly-Thr, GT) or glycine-serine (Gly-Ser, GS) peptides with zinc (Zn) ions, achieving either continuous or discrete threshold water-sorption-dependent phase transitions.

The fruits of data shepherding: A collection of open FAIR datasets for titanium dioxide coated photocatalytic surfaces.

This paper presents a large-scale collaborative effort within a multi-partner consortium, to systematically structure, curate, and openly share data in alignment with the FAIR principles. The data result from a case study of titanium dioxide (TiO₂) nanomaterials (NMs) for photocatalytic depolluting surfaces, produced via various spray coating techniques under the Safe and Sustainable by Design (SSbD) approach. The data are publicly available through a dedicated Zenodo community (https://zenodo.

Protocol for a randomized controlled trial of a resistance exercise training to treat major depression via cerebrovascular mechanisms (RESIST Trial).

Background: Many adults with major depressive disorder (MDD) do not engage in treatment and may also not respond when current frontline treatments are completed. Resistance exercise training (RET) is an understudied behavioral treatment option, which may help with MDD management through improving cerebral blood flow that is commonly impaired in adults with MDD. The purpose of this study is to use gold-standard research methods to determine the validity (clinical efficacy) of RET for treating MDD and to determine potential cerebrovascular pathways through which RET might improve MDD symptoms.

Arab2Vec: An Arabic word embedding model for use in Twitter NLP applications.

The analysis of Arabic Twitter data sets is a highly active research topic, particularly since the outbreak of COVID-19 and subsequent attempts to understand public sentiment related to the pandemic. This activity is partially driven by the high number of Arabic Twitter users, around 164 million. Word embedding models are a vital tool for analysing Twitter data sets, as they are considered one of the essential methods of transforming words into numbers that can be processed using machine learning (ML) algorithms.

Clinical impact of MRI-based risk calculators for prostate cancer diagnosis: a systematic review and meta-analysis.

Background: Prostate cancer (PCa) is the second most common cancer among men worldwide. Current diagnostic methods often lack sufficient sensitivity and specificity, leading to unnecessary biopsy. With growing use of MRI and EAU guideline recommendations, this review synthesised evidence on MRI-based risk calculators (RCs) for PCa diagnosis and compared their performance with traditional clinical RCs.

Tribology of EDM Recast Layers Vis-À-Vis TIG Cladding Coatings: An Experimental Investigation.

Tribological performance is critical for the longevity and efficiency of machined components in industries such as aerospace, automotive, and biomedical. This study investigates whether electrical discharge machining recast layers can serve as a cost-effective and time-efficient alternative to conventional tungsten inert gas cladding coatings for enhancing surface properties. The samples were prepared using electrical discharge machining and tungsten inert gas cladding.

Shoulder pain phenotyping: A guide for clinicians to determine predominant nociceptive, neuropathic, or nociplastic shoulder pain.

Background: Persistent shoulder pain is common, and it is associated with substantial morbidity and healthcare costs. Approximately 21 to 50 % of people with shoulder pain treated in primary healthcare recover within six months. It is not known why at least half do not recover.

Facilitators and barriers to engaging in expressive writing among health and social care professionals.

Healthcare workers in the UK report high levels of burnout and poor wellbeing, and interventions are urgently needed to address this issue. Expressive writing, whereby individuals write about emotionally laden thoughts or experiences, is an effective intervention for reducing stress and enhancing wellbeing, and is a potential candidate for use with healthcare workers. However, it is crucial that the preferences of healthcare workers are taken into account in the design of future trials in this area, and that perceived barriers and facilitators to engaging with expressive writing activities are considered.

Assessing online search results for misinformation about reduced fetal movements.

Introduction: Reduced fetal movements (RFM) is a warning sign during pregnancy and must be assessed immediately. As pregnant women search online for RFM information before consulting with healthcare professionals, the accuracy of online information is crucial. Misinformation can lead to delayed medical attention and adverse outcomes.

Utilization of a novel radio-opaque 3D printed phantom for simulation training of CT-guided interventional procedure.

Background: Training radiology residents to perform CT-guided procedures can be challenging due to limited access to scanner time, competition for procedures with other residents and fellows and the risk of exposing patients to unnecessary additional radiation due to the inexperience of the primary operator. Simulation training has shown great benefit in reducing patient risk and increasing training opportunities. The aim of this study was to assess the impact of a high-fidelity 3D-printed model as an interventional radiology training tool for trainees.

Evolutionary perspectives on ADHD.

Objectives: This study explores psychiatrists' perceptions of Attention-Deficit Hyperactivity Disorder (ADHD) through the lens of evolutionary psychiatry, a growing field that reframes mental disorders in the context of adaptation and survival. Evolutionary theories suggest that traits associated with ADHD, such as impulsivity, hypercuriosity and novelty-seeking, may have been adaptive in ancestral environments, though they manifest as maladaptive in structured modern contexts.

Method: A bespoke 10-item questionnaire was developed to assess psychiatrists' attitudes following a presentation on evolutionary perspectives of ADHD by an expert.

Depression among people with low back pain: a cross-sectional descriptive survey of Irish musculoskeletal triage physiotherapists' screening and referral practices.

Background: Low back pain (LBP) is associated with a poorer prognosis when there is concomitant depression. Musculoskeletal (MSK) triage physiotherapists clinically assess a significant proportion of LBP referrals to public hospital outpatient waiting lists.

Objectives: To establish depression screening and referral practices of MSK triage physiotherapists, and to compare confidence in depression screening to red flag (e.

High-performance all-inorganic CdSe/CdS nanorod-based light emitting diodes enabled by controlled electrophoretic deposition.

Electrophoretic deposition can be used to form tightly assembled nanocrystal films at a macroscopic scale, offering tremendous possibilities to exploit the unique functional properties of nanocrystals at a device level. Herein, combining the experimentally measured electrophoretic deposition current time trace with an analytical model, we can estimate the effective single particle charge in solution and obtain information on the morphology and thickness of the film. Using this method, we formed vertically aligned, void-free CdSe/CdS nanorod (NR) films as the emissive layers in red-emitting all-inorganic NR light emitting diodes.

Disparity between statistical significance and clinical importance in published randomised controlled trials: a methodological study.

Objectives: We estimated the extent of the disparity between statistical significance and clinical importance in published randomised controlled trials (RCTs), and explored factors associated with this disparity.

Design: A methodological study of trials published between 2018 and 2022 and indexed in PubMed was conducted. Primary reports of two-arm, phase three, superiority trials of human health interventions were included.

Hydrodynamic Cavitation-Based Pretreatment of Primary Digestate: Feasibility and Role in Overall Enhancement of Valorization.

Hydrodynamic cavitation (HC) is a promising biomass pretreatment technology for enhancing methane production from anaerobic digestion (AD). While HC has been widely studied for sludge and fresh biomass feedstock, its application to digestate remains largely unexplored. This study evaluates the impact of HC pretreatment on digestate from different sources to enhance biochemical methane potential (BMP) and biodegradability.

Psychopathy, neuroscience, and critical issues: A legal primer.

Psychopathy occupies a pivotal yet unsettled position at the intersection of neuroscience, business ethics, and criminal jurisprudence. Despite rapid scientific advances, core uncertainties remain. This article examines five issues of immediate legal relevance: (1) the contested neurobiological basis of psychopathy; (2) reproducibility concerns linked to the broader replication crisis in psychological and neuroscientific research; (3) limitations of leading assessment instruments (e.

The Road to Designing Integrated Neuromuscular Training Programs for Children and Adolescents: A Systematic Review and Meta-Analysis.

Li, M, Crotti, M, Martins, R, Tiernan, C, Lyons, M, Lander, N, Barnett, LM, and Duncan, MJ. The road to designing integrated neuromuscular training programs for children and adolescents: A systematic review and meta-analysis. J Strength Cond Res 39(8): e1043-e1060, 2025-Integrative neuromuscular training (INT) combines motor competence and strength development to boost athletic performance, but its specific components and effects on children and adolescents are not well understood.

Mental health and the environment - evolutionary perspectives.

This paper provides an overview of key concepts in evolutionary psychiatry, summarising major evolutionary explanations for mental illness and highlighting the potential of these perspectives to enhance assessment, diagnosis, explanation to the patient, treatment and prevention strategies. Expanding beyond conventional evolutionary approaches, we explore environmental influences on mental health and illness, emphasising the significant areas of convergence between evolutionary and environmental viewpoints. We then propose an integrated framework that combines insights from both perspectives, offering general principles for improving mental health outcomes at both individual and population levels.