Responses of different life stages of Physa acuta (Draparnaud, 1805) to the pesticides imidacloprid and tebuconazole: effects on growth, reproduction, and behavior.

Aquatic pollution caused by pesticides raises concerns about the effects on wildlife. While risk assessment protocols with invertebrates focus mainly on arthropods, the effects on gastropods are underexplored. In this way, the impact of exposure to imidacloprid, a neonicotinoid insecticide, and tebuconazole, an azole fungicide, on different life stages of the freshwater snail Physa acuta was investigated.

Rapid C Solid-State Quantitative NMR Method for Multiple Physical and Chemical Analyses of Cocoa-Based Products: Proof of Concept.

Chocolates and other cocoa products represent a multibillion-dollar industry that has faced significant price increases, largely due to a surge in cocoa plant diseases linked to climate change. One potential solution for mitigating cocoa prices involves the use of cocoa butter equivalents, substitutes, or replacers. Consequently, a rapid method for simultaneously determining multiple properties of cocoa derivatives can serve as a valuable tool for research and development of new products, quality control, and regulatory agencies to ensure compliance with cocoa product standards.

Occurrence of Listeria spp. and Listeria monocytogenes in half-carcasses, meat cuts, equipment, and the environment of bovine slaughterhouses in Brazil.

Human listeriosis is a severe food-borne illness, with fatality rates ranging from 20 to 30 %. In Brazil, despite being an underdiagnosed and underreported disease, the presence of the microorganism in food has been the subject of important studies. However, its occurrence in slaughterhouse environments has received little attention in recent years.

Multimodal Treatment Of Hemangiolymphangioma in a Pediatric Patient: Case Report and Literature Review.

Background: Hemangiolymphangioma is an uncommon benign lesion characterized by the simultaneous presence of both vascular and lymphatic vessels. It has been rarely reported, and its occurrence in the oral cavity is even rarer compared to other regions, with only 18 cases published in the English-language literature. In addition, there are doubts about the best approach.

Mapping advance care planning and advance directives in Latin America.

Background/aims: The extent to which low- and middle-income countries have implemented Advance Care Planning (ACP) and Advance Directives (AD) remains unclear. We aimed to map the current status of ACP/AD in Latin America.

Methods: This cross-sectional, mixed-methods survey of ACP/AD in LA comprised interviews with 18 key informants from 18 out of 20 countries, most of whom were appointed by national Palliative Care Associations.

Caspase-1 Activation Drives Vascular Inflammatory Processes and Hypoperfusion in Intravascular Hemolysis.

Intravascular hemolysis (IVH), a pathological process associated with various conditions, triggers inflammatory responses, yet the key molecular drivers of these responses are poorly defined, particularly within the vasculature. To explore the role of NLRP3 inflammasome- and caspase-1-dependent pathways in IVH-induced vascular dysfunction, we used models of acute and chronic IVH, alongside heme stimulation of endothelial cells, thereby isolating this disease mechanism from its etiological causes. IVH induced rapid inflammatory responses in C57BL/6J mice, including IL-1β release within 15 minutes, and NLRP3-dependent caspase-1 activation in circulating leukocytes.

Insights from the first 820 patients from the Brazilian Multicenter Registry of Hereditary Angioedema: the key role of genetic testing and targeted therapies.

Background: Hereditary angioedema (HAE) is a rare autosomal dominant disorder with a prevalence of 1:50,000 individuals. Delayed diagnosis and deaths from asphyxia still occur.

Objective: To identify knowledge and management gaps regarding clinical, genetic, and therapeutic aspects of HAE in Brazil, aiming to improve patient care and outcomes.

Myo-inositol is a key regulator of avian metabolism: From mechanisms to seasonal behavior.

Being naturally hyperglycemic and insulin insensitive, birds maintain plasma glucose levels twice as high as mammals of similar size. Recent evidence suggests that perturbation of myo-inositol (MI) plays a role in mammalian hyperglycemic regulation. Using an integrative approach, we identify a fundamental role of MI in avian metabolism.

Reducing post-cesarean sepsis: Current best practice in prevention and treatment.

Cesarean section is the most common surgical procedure performed worldwide. It is associated with good perinatal and maternal outcomes when indicated. The rising global cesarean birth rate has coincided with an increase in post-cesarean sepsis - specifically site infections, which have an incidence of 7% worldwide.

Longitudinal Evaluation of Ataxia and Brain Structural Changes in RFC1-Related Disorder.

Background: The progression of brain damage in CANVAS/RFC1 remains unclear.

Objective: To describe longitudinal brain changes in CANVAS/RFC1.

Methods: Ten RFC1-positive patients and 10 controls underwent 3T-MRI scans 2 years apart.

Interleukin-6 Modulates Endoplasmic Reticulum Stress Signaling and Mitochondrial Protein Complexes in the Kidney Following Acute Exhaustive Exercise.

Endoplasmic Reticulum (ER) homeostasis is closely regulated by an adaptive signaling network identified as the unfolded protein response (UPR), which is tightly related to the inflammatory pathway. However, physical exercise increases plasma concentrations of interleukin-6 (IL-6), which exhibits both pro- and anti-inflammatory properties that mediate ER function and mitochondrial metabolism, making its investigation relevant in physiological and pathological contexts. In kidney diseases, the IL-6 levels are effective in predicting mortality risk.

A Clinicopathological Study of Marginal Gingival Leukoplakia.

Background: Marginal gingival leukoplakias are relatively uncommon and rarely discussed in the scientific literature. Studies suggest they are distinct from other leukoplakias due to aggressive behavior and a strong association with proliferative verrucous leukoplakia. This study aimed to evaluate the clinicopathological characteristics of patients diagnosed with marginal gingival lesions.

Oral and Maxillofacial Pathology in Latin America and the Caribbean: A Comprehensive Survey of Recognition, Training, and Practice.

Background: Oral and maxillofacial pathology (OMFP) is a dental specialty that studies the causes, processes, and effects of diseases in the oral and maxillofacial area, while also contributing to diagnosis and treatment. Its recognition, training, and professional practice vary across the globe. This study aimed to explore the training and professional development of OMFP in Latin America and the Caribbean (LAC), including important issues such as specialty recognition, service regulation, postgraduate education, number of specialists, career opportunities, and perceived barriers.

The source-sink dynamics of Plasmodium vivax may undermine malaria elimination efforts in the Amazon: an epidemiological and population genomic study.

Background: Brazil's progress toward malaria elimination has stalled and 163,000 new cases (more than 80% caused by Plasmodium vivax) were recorded in the Brazilian Amazon in 2023. We hypothesize that human mobility continues to disperse parasites from hotspots to areas with decreasing endemicity.

Methods: We analyzed 5.

Psychedelics for substance use disorders: are women being addressed? A scoping review.

Introduction: Substance use disorders (SUDs) are a prevalent health issue that affects individuals globally. Research is currently being conducted on the potential use of psychedelics as a new approach to treating SUDs. Women have been shown to respond differently than men to SUDs treatments and women-specific approaches have been recommended.

Does ultrasound detect joint and intestinal changes in psoriatic arthritis and ulcerative colitis after immunobiological treatment: A case report.

Background: Ultrasound (US) can be a valuable tool for assessing arthritis associated with inflammatory bowel disease (IBD), especially in cases of psoriatic disease. The clinical case reviewed in this article addresses an exploratory finding that evaluates the effects of immunobiological treatments on dactylitis and IBD with the use of US techniques.

Case Summary: A 40-year-old Caucasian woman with psoriatic arthritis (PsA) and ulcerative colitis (UC) reported experiencing finger pain, knee arthritis, and bloody diarrhea.

A Randomized Controlled Trial Comparing Two Techniques of Enteral Feeding Tube Placement in Critically Ill Newborn Infants.

Background: Feeding intolerance can hinder enteral nutrition in infants, often necessitating transpyloric tube feeding. However, the success of transpyloric tube placement varies.

Purpose: To compare the rate of correct transpyloric tube placement in infants with and without gastric air insufflation, and to assess complications associated with postpyloric feeding.

Efficacy and Safety of Bariatric Surgery in Well-Compensated Liver Cirrhosis: A Systematic Review and a Single-Arm Meta-analysis.

Introduction: The global rise in obesity and liver disease underscores the significance of bariatric and metabolic surgery (BMS) in treating severe obesity and improving liver function. Although liver failure is often considered a contraindication for elective surgeries, the role of bariatric surgery in patients with compensated cirrhosis has been increasingly explored.

Methods: We systematically searched PubMed, Embase, and Cochrane without temporal restrictions, in January 2025 for randomized controlled trials and observational studies.

Integrating Holistic Communication into Psychedelic-Assisted Therapies in Hospice and Palliative Care: An Approach Based on Peplau's Theory.

Psychedelic-assisted therapy (PAT) has shown promising results in alleviating psychological and existential suffering among individuals with serious illnesses. In parallel, nursing offers a robust theoretical framework to guide therapeutic communication in this context. This article explores the application of Peplau's Theory of Interpersonal Relations (PTIR) as a foundation for holistic communication in PAT, particularly in hospice and palliative care.

How climate change and deforestation interact in the transformation of the Amazon rainforest.

The Amazon rainforest is one of Earth's most diverse ecosystems, playing a key role in maintaining regional and global climate stability. However, recent changes in land use, vegetation, and the climate have disrupted biosphere-atmosphere interactions, leading to significant alterations in the water, energy, and carbon cycles. These disturbances have far-reaching consequences for the entire Earth system.

Biorefining lignocellulose into feed and food: the case of sugarcane and a technology outlook.

This Perspective explores how new technologies can expand lignocellulose biorefineries to include coproducts for animal feed and microbial protein with potential applications in human food. Using the Brazilian sugarcane industry as a case study, the analysis highlights synergies from the spatial coexistence of sugarcane and livestock, as well as economies of scale and product multiplicity in biorefineries. The technology outlook examines selected biomass pretreatments that can generate pretreated biomass with dual use: reactive intermediate for cellulosic ethanol production and ruminant nutrition.

Glycemic load, glycemia, and self-reported diabetes mellitus in community-dwelling older adults: a 24-hour dietary recall-based assessment.

Objective: This study aimed to evaluate the Glycemic Load (GL) of foods consumed by community-dwelling older individuals, considering fasting blood glucose levels, self-reported Diabetes Mellitus (DM), and socioeconomic and nutritional factors.

Methods: A cross-sectional study was conducted in the Campinas-SP region, utilizing a convenience sample of 584 participants aged ≥ 60 years. Food consumption was assessed using a 24-hour recall.

Functionalized Silk Fibroin and Mucin Hybrid Material for Targeted EGF and Papain Delivery in Wound Healing.

Silk fibroin (SF) and mucin are extensively recognized as promising biomaterials for wound dressings due to their outstanding biocompatibility, biodegradability, and ability to support cell growth and tissue regeneration. In this study, we developed a hybrid SF/mucin wound dressing (HYB) using tetrazine and norbornene click chemistry to enhance its structural and functional properties. The robust assembly resulted in a dual-phase material with a dense SF membrane and a porous mucin hydrogel (MH).