Longitudinal Evaluation of Ataxia and Brain Structural Changes in RFC1-Related Disorder.

Background: The progression of brain damage in CANVAS/RFC1 remains unclear.

Objective: To describe longitudinal brain changes in CANVAS/RFC1.

Methods: Ten RFC1-positive patients and 10 controls underwent 3T-MRI scans 2 years apart.

Automated Deep Learning-based Segmentation of the Dentate Nucleus Using Quantitative Susceptibility Mapping MRI.

Purpose To develop a dentate nucleus (DN) segmentation tool using deep learning (DL) applied to brain MRI-based quantitative susceptibility mapping (QSM) images. Materials and Methods Brain QSM images from healthy controls and individuals with cerebellar ataxia or multiple sclerosis were collected from nine different datasets (2016-2023) worldwide for this retrospective study (ClinicalTrials.gov Identifier: NCT04349514).

EEG alpha and theta time-frequency structure during a written mathematical task.

Since the first electroencephalogram (EEG) was obtained, there have been many possibilities to use it as a tool to access brain cognitive dynamics. Mathematical (Math) problem solving is one of the most important cortical processes, but it is still far from being well understood. EEG is an inexpensive and simple indirect measure of brain operation, but only recently has low-cost equipment (mobile EEG) allowed sophisticated analyses in non-clinical settings.