Management on late diagnosed Fournier's gangrene in elderly patient and it's complication: A case reports.

Introduction And Importance: One of the risk factors linked to mortality in Fournier Gangrene (FG) is the elderly. When this risk is present and diagnosed too late, patient care may become difficult. This case report discusses the treatment of an older patient with late-diagnosed Fournier's gangrene and its consequences in this background.

Efficacy and Safety Profile of Low-Dose Tranexamic Acid Regimen in Cardiac Surgery: A Meta-Analysis.

Introduction: Various dosing regimens of tranexamic acid have been reported to exhibit varying efficacy and safety profiles. Herein, we conducted a meta-analysis to evaluate the efficacy and safety of low-dose regimens in open-heart surgery.

Methods: Three databases were systematically searched for randomized trials examining the bleeding reduction effect of tranexamic acid in open-heart surgery.

Antibiotic prescribing for children five years or younger in Indonesian primary care settings.

Introduction: Children are at a higher risk of antibiotic overprescribing, while limited surveillance is evident in primary care settings. This study aims to examine patterns of infections and associated antibiotic use in children attending Primary Health Centers (PHCs), including an explanatory analysis of antibiotics for non-pneumonia acute respiratory infections (ARIs), pneumonia, and diarrhea.

Methodology: An observational study used records of all children  5 years of age prescribed antibiotics from January 2019 to December 2020 in selected PHCs in Surabaya and Banjarmasin, Indonesia.

International REACH forgiveness intervention: a multisite randomised controlled trial.

Objectives: To determine whether a brief self-directed forgiveness workbook intervention could alter forgiveness, depression symptoms, and anxiety symptoms.

Design: A multisite randomised waitlist-controlled trial was conducted among 4598 participants. Recruitment occurred from 11 February 2020 to 30 September 2021.

Progression of pulmonary arterial hypertension: A study in model.

Background: The pathophysiology of pulmonary arterial hypertension (PAH) is complex. Pathology and molecular biology signatures during its progression are interesting to study.

Aim: This study will describe PAH progression from the first until the fourth week in a model focussing on endothelin-1 (ET-1), tumor necrosis factor α (TNF-α), extracellular signal-regulated kinase 1/2 (ERK1/2), intima media thickness (IMT), and proliferation of pulmonary arterial smooth muscle cells (PASMCs) and fibroblast.

Exploring links between visuospatial ability and anatomy learning in education: A bibliometric analysis and scientific mapping.

The field of medical education faces a significant challenge in teaching human anatomy, a fundamental aspect of medical science that is often perceived as complex and demanding. Understanding the shapes and anatomical structure locations is crucial for students to master the intricacies of anatomy. Visuospatial ability, which involves comprehending three-dimensional structures and their spatial relationships, plays a pivotal role in anatomy learning.

Massive hydropyonephrosis on pediatric patient: A case report of management and source control.

Introduction And Importance: Dilation and stretching of the collecting system of the kidney due to obstruction of urine flow is called hydronephrosis. This case may be accompanied by the presence of pus known as pyonephrosis. This case report reporting massive pyonephrosis in pediatrics related to management and source of control.

A pilot study for speech assessment to detect the severity of Parkinson's disease: An ensemble approach.

Background: Changes in voice are a symptom of Parkinson's disease and used to assess the progression of the condition. However, natural differences in the voices of people can make this challenging. Computerized binary speech classification can identify people with PD (PwPD), but its multiclass application to detect the severity of the disease remains difficult.

Reflexive eye saccadic parameters in Parkinson's disease.

Introduction: Abnormal reactive saccade, with reduced saccadic gain, impaired smooth pursuit, and unwarranted reactions are clinically used to assess people with Parkinson's disease (PwPD). However, there are inconsistent findings related to other saccade parameters such as latency and transition times. This study aimed to identify differences in the reflexive saccade parameters of early stage PwPD and aged-matched control (AMC).

Outcome of delayed presentation in patients with giant renal cell carcinoma: A case report.

Introduction And Importance: Renal cell carcinoma (RCC) is a common form of malignancy that causes many deaths worldwide. One of the RCC cases that is challenging and requires proper treatment is a large tumor. This report explores the delayed presentation and treatment of giant RCC.

Metabolism and diabetes in Ramadan fasting: Exploring health trends and relationships through systematic literature network analysis.

Ramadan fasting is widely acknowledged for its positive impacts on health, yet it also presents inherent risks, prompting a need for comprehensive exploration into its metabolic implications and its effects on diabetes. This study introduces a novel methodology called systematic literature network analysis (SLNA), which merges bibliometric analysis with systematic literature review (SLR). The aim of this study was to examine the global research landscape concerning Ramadan fasting, metabolism, and diabetes.

Promising brain biodistribution of insulin via intranasal dry powder for nose-to-brain delivery.

Nose-to-brain delivery (NTBD) offering potential benefits for treating Alzheimer's disease. In previous research, insulin dry powder (IDP) formulation for NTBD was developed, exhibiting favorable stability. This study aims to conduct and assessment of release, permeation, mucoadhesion and histopathology, as well as an biodistribution study to produce IDP for NTBD and evaluate brain biodistribution.

Mapping medication selling practices at nonpharmacy outlets during the COVID-19 pandemic: an example of Indonesia.

Objectives: Nonpharmacy outlets are common medication suppliers in Indonesia, yet little is known regarding their practices. This study aimed to evaluate the medication selling practices occurring in kiosks and minimarkets during the coronavirus disease 2019 pandemic.

Methods: A cross-sectional study included all minimarkets (N = 101) and a convenience sample of kiosks (a minimum sample size, N = 67) in District X, Indonesia.

Comparison of QTc interval changes in drug-resistant tuberculosis patients on delamanid-containing regimens versus shorter treatment regimens.

Background: Delamanid (DLM) is a relatively new drug for drug-resistant tuberculosis (DR-TB) that has been used in Indonesia since 2019 despite its limited safety data. DLM is known to inhibit hERG potassium channel with the potential to cause QT prolongation which eventually leads to Torsades de pointes (TdP).

Objective: This study aims to analyse the changes of QTc interval in DR-TB patients on DLM regimen compared to shorter treatment regimens (STR).

The Apo gene's genetic variants: hidden role in Asian vascular risk.

Vascular risk factors, including diabetes, hypertension, hyperlipidemia, and obesity, pose significant health threats with implications extending to neuropsychiatric disorders such as stroke and Alzheimer's disease. The Asian population, in particular, appears to be disproportionately affected due to unique genetic predispositions, as well as epigenetic factors such as dietary patterns and lifestyle habits. Existing management strategies often fall short of addressing these specific needs, leading to greater challenges in prevention and treatment.

Bipolar Membrane Seawater Splitting for Hydrogen Production: A Review.

The growing demand for clean energy has spurred the quest for sustainable alternatives to fossil fuels. Hydrogen has emerged as a promising candidate with its exceptional heating value and zero emissions upon combustion. However, conventional hydrogen production methods contribute to CO emissions, necessitating environmentally friendly alternatives.

Twelve tips to virtually operationalize co-creation of educational design.

Co-creation is the active involvement of all stakeholders, including students, in educational design processes to improve the quality of education by embodying inclusivity, transparency and empowerment. Virtual co-creation has the potential to expand the utility of co-creation as an inclusive approach by overcoming challenges regarding the practicality and availability of stakeholders, typically experienced in face-to-face co-creation. Drawing from the literature and our experiences of virtual co-creation activities in different educational contexts, this twelve tips paper provides guidelines on how to effectively operationalize co-creation in a virtual setting.

Application of CRISPR-Cas9 genome editing technology in various fields: A review.

CRISPR-Cas9 has emerged as a revolutionary tool that enables precise and efficient modifications of the genetic material. This review provides a comprehensive overview of CRISPR-Cas9 technology and its applications in genome editing. We begin by describing the fundamental principles of CRISPR-Cas9 technology, explaining how the system utilizes a single guide RNA (sgRNA) to direct the Cas9 nuclease to specific DNA sequences in the genome, resulting in targeted double-stranded breaks.

Situations that prompt teachers in problem-based curricula to reflect on their beliefs, identity and mission.

Teachers have different perceptions of how to enhance student learning. Whereas some take a teacher-centred perspective, others lean more towards a student-centred approach. Many studies in higher education have invoked Korthagen's onion model (2014) to explain how teachers' perspectives can impact their teaching practices.