Spiritual Support for People Affected by Dementia: A Scoping Review.

As a life-limiting illness, dementia requires a holistic approach to care, where spiritual support plays a crucial role in helping individuals and their caregivers find meaning and solace. Our aim was to systematically map the research conducted on psychosocial interventions developed to provide spiritual support for people living with dementia and their caregivers from diagnosis and across the disease trajectory. A scoping review was conducted to explore the breadth of research on 'spiritual support' in dementia care, encompassing interventions, service delivery models, programs, toolkits, approaches, and activities.

Effects of a Board Game on Tic Management and Psychosocial Functioning in Adolescents With Tourette Syndrome: Randomized Controlled Trial.

Background: Tics and comorbidities significantly impact the social interactions and mental health of adolescents with Tourette syndrome (TS). Psychoeducation is an initial intervention for TS. Gamification is a common psychoeducational intervention for youths with chronic conditions.

Acute Metabolic and Muscle Oxygenation Responses to Different Eccentric Tempos Under a Fixed Velocity-Loss Threshold in Squat.

Purpose: This study explored the acute physiological effects of different eccentric tempos, explosive speed (EXP), volitional speed, and 4-second tempo during 5 sets of velocity-based squat training.

Methods: Twelve healthy males performed parallel squats under 3 eccentric conditions using a randomized crossover design. Each session included 5 sets at a relative load, initiated with a concentric mean velocity of 0.

Centrosome dysfunction and autophagy dysregulation in renal cell carcinoma: Implications for tumor progression and therapy.

Renal cell carcinoma (RCC) is a heterogeneous kidney malignancy driven by complex genetic, molecular, and metabolic alterations. Emerging evidence implicates centrosome dysfunction and autophagy dysregulation in RCC initiation, progression, and resistance to therapy. The centrosome plays a critical role in mitotic fidelity, and its dysfunction often leads to chromosomal and genomic instability.

Lignin-mediated AgCoOS bimetal oxysulfide catalysts for highly efficient catalytic reduction of organic and Cr(VI) pollutants in the dark.

Lignin, a negatively charged, three-dimensional natural biopolymer, serves as an ideal support for metal catalysts due to its abundant functional groups and tunable chemical properties, which enable strong metal coordination and effective immobilization. Herein, we demonstrate a lignin-mediated Co/O co-doped AgS, symbolized as L-AgCoOS, bimetal oxysulfide catalyst via a facile hydrolysis method for the efficient reduction of toxic phenolic compounds (4-nitrophenol, 4-NP), organic dyes (methyl orange (MO), methylene blue (MB), rhodamine B (RhB), and heavy metal ions Cr(VI)) under dark conditions. Lignin, used to immobilize catalysts, also contributes to increasing the number of active catalytic sites and enhancing catalytic activity.

From Beetle to Bot: Bioinspired Design of Robotic Grippers Based on Stag Beetle Mandible Biomechanics.

Conventional rigid grippers remain the most-used robotic grippers in industrial assembly tasks. However, they are limited in their ability to handle a diverse range of objects. This study draws inspiration from nature to address these limitations, employing multidisciplinary methods, such as computer-aided design, parametric modeling, finite element analysis, 3D printing, and mechanical testing.

Nurses' perceptions of artificial intelligence adoption in healthcare: A qualitative systematic review.

Aim: This study aimed to systematically review and synthesize the most recent qualitative studies on frontline nurses' insights and perspectives regarding the use of artificial intelligence (AI) tools in their clinical practice in hospital settings.

Background: There is limited information on frontline nurses' perceptions, attitudes and expectations regarding the adoption of AI in healthcare.

Design: A systematic review and thematic synthesis of qualitative evidence was conducted.

Effectiveness of augmented reality simulation on oncology nurses' knowledge and clinical reasoning in malignant fungating wound care: Randomized controlled trial.

Aim: To evaluate the effectiveness of the CARES-MFW (Clinical Augmented Reality Education Simulation for Malignant Fungating Wounds) app in enhancing nurses' knowledge and clinical reasoning in the care of MFWs.

Background: Malignant fungating wounds (MFWs) affect many patients with advanced cancer, with nearly 50 % dying within six months of diagnosis. These wounds often present with heavy exudate, pain, malodor and bleeding, leading to profound physical and psychosocial distress.

Genomic analysis of the in Taiwan: a nationwide study from 2006 to 2022.

remains a leading respiratory pathogen for children and the elderly. In Taiwan, a national PCV13 catch-up vaccination programme for children began in March 2013. This study investigates the population structure and antimicrobial profiles of pneumococcal isolates in Taiwan from 2006 to 2022.

Two Cases of Primary Melanoma of the Uterine Cervix.

BACKGROUND This study reports on 2 cases of cervical melanoma with similar presentations but at different stages, and the treatment strategy varied accordingly, and we review the literature on the characteristics, diagnosis, and management of cervical melanoma. CASE REPORT Case 1: A 69-year-old woman with abnormal vaginal bleeding was diagnosed with advanced cervical melanoma, staged as International Federation of Gynecology and Obstetrics (FIGO) Stage IVB, involving multiple metastases. Despite chemoradiotherapy and immunotherapy (nivolumab), the disease progressed rapidly, and the patient died 4 months after diagnosis.

Assessing Soil Pollution Potential through Spatial Heavy Metal Bioaccessibility for Health Risk Evaluation.

Incorporating bioaccessibility into health risk assessments enhances the accuracy of exposure estimates for heavy metal (HM) pollution, supports targeted remediation, and informs public health and policy decisions, particularly for vulnerable populations. Because HM bioaccessibility depends on local soil and geographic characteristics, identifying its relationship with soil properties is crucial for assessing soil pollution potential. Although HM concentrations can be measured relatively easily, bioaccessibility requires complex laboratory procedures, limiting routine applications in regulatory contexts.

Antithrombin-binding heparan sulfate is ubiquitously expressed in epithelial cells and suppresses pancreatic tumorigenesis.

3-O-sulfation of heparan sulfate (HS) is the key determinant for binding and activation of Antithrombin III (AT). This interaction is the basis of heparin treatment to prevent thrombotic events and excess coagulation. Antithrombin-binding HS (HSAT) is expressed in human tissues, but is thought to be expressed in the subendothelial space, mast cells, and follicular fluid.

Effectiveness of backward walking exercises combined with conventional rehabilitation programs on managing pain intensity and disability in patients with knee osteoarthritis: A systematic review and meta-analysis of randomized controlled trials.

Background: Knee osteoarthritis (OA) causes pain and diminishes quality of life. Backward walking exercise (BWE) has been shown to improve lower muscle strength and reduce knee adduction moment, making it a recommended intervention for knee OA rehabilitation. This study aims to evaluate the effectiveness of BWE combined with conventional rehabilitation programs on pain intensity and disability among individuals with knee OA.

The Applied Sport Science and Medicine of Powerlifting and Para Powerlifting: A Systematic Scoping Review with Recommendations for Future Research.

Background: Powerlifting is a strength sport featuring some of the world's strongest athletes. Recent decades have seen an exponential increase in research into the applied sport science and medicine of powerlifting and its Paralympic counterpart, para powerlifting. A scoping review of the area would provide athletes, coaches, policymakers, and researchers with an overview of the existing evidence to support performance, reduce injury, and foster further growth of these sports.

Structure-guided loop grafting improves expression and stability of influenza neuraminidase for vaccine development.

Influenza virus neuraminidase (NA) is a crucial target for protective antibodies, yet the development of recombinant NA protein as a vaccine has been held back by instability and variable expression. We have taken a pragmatic approach to improving expression and stability of NA by grafting antigenic surface loops from low-expressing NA proteins onto the scaffold of high-expressing counterparts. The resulting hybrid proteins retained the antigenic properties of the loop donor while benefiting from the high-yield expression, stability, and tetrameric structure of the loop recipient.

Enhanced Versus Standard Dermatologic Management With Amivantamab-Lazertinib in EGFR-Mutated Advanced NSCLC: The COCOON Global Randomized Controlled Trial.

Introduction: Amivantamab plus lazertinib significantly improved progression-free and overall survival versus osimertinib in patients with previously untreated, EGFR-mutant advanced NSCLC. EGFR-targeted therapies are associated with dermatologic adverse events (AEs), which can affect quality of life (QoL). COCOON was conducted to assess prophylactic management and improve treatment experience.

Leveraging for an Exquisite Symmetric Supercapacitor─A Cost-Effective MnCO Synthesis Approach for Energy Storage Application.

Sugarcane () was employed as a sustainable carbon source to synthesize three-dimensional (3D) spherical manganese carbonate (MnCO) microspheres, offering a green route to advanced electrode material for high-energy-density symmetric supercapacitors. Although numerous synthesis strategies and material modifications have been explored, a detailed evaluation of environmentally friendly synthesis pathways remains essential. In this study, MnCO microspheres were successfully synthesized via a sugar-derived green synthesis followed by hydrothermal treatment.

Overall Survival with Amivantamab-Lazertinib in -Mutated Advanced NSCLC.

Background: Previous results from this phase 3 trial showed that progression-free survival among participants with previously untreated (epidermal growth factor receptor)-mutated advanced non-small-cell lung cancer (NSCLC) was significantly improved with amivantamab-lazertinib as compared with osimertinib. Results of the protocol-specified final overall survival analysis in this trial have not been reported.

Methods: We randomly assigned, in a 2:2:1 ratio, participants with previously untreated -mutated (exon 19 deletion or L858R substitution), locally advanced or metastatic NSCLC to receive amivantamab-lazertinib, osimertinib, or lazertinib.

Genomic Analysis for the Safety Assessment of a Potential Probiotic Strain Pediococcus pentosaceus BBS1 Isolated From Lao Fermented Bamboo Shoots (Nor Mai Som).

Currently, there is an increasing use of whole-genome sequencing (WGS) studies to investigate the molecular taxonomy, metabolic properties, enzyme capabilities, and bioactive substances of lactic acid bacteria (LAB) species. In this study, the genome of strain Pediococcus pentosaceus BBS1 was sequenced using the Illumina HiSeq. 2500 platform to determine its classification, annotate its main features, and evaluate its safety characteristics.

The Proteomic Profiling of Circulating Extracellular Vesicles of Western Diet and Chemical-Induced Murine MASH Model.

Metabolic dysfunction-associated steatotic liver disease (MASLD) is an increasingly prevalent chronic liver condition that can progress to severe complications such as metabolic dysfunction-associated steatohepatitis (MASH). Despite its growing burden, there are no reliable non-invasive biomarkers for tracking disease progression. In this study, we established a murine MASLD/MASH model using a high-fat diet and chemical (CCl) induction.

Novel Grm6 Variant in a no b-wave (nob) Mouse Model: Phenotype Characterization and Gene Therapy.

Purpose: To characterize a no b-wave (nob) mouse model of congenital stationary night blindness (CSNB) caused by a Grm6 variant that disrupts photoreceptor-to-bipolar cell signaling. Additionally, we aim to evaluate the efficacy of gene therapy in restoring visual function.

Methods: The nob mouse was generated through selective breeding to regenerate the nob phenotype.

The Association Between Use of Inhaled Corticosteroids and Long-Acting Beta2-Agonists During Pregnancy and Adverse Fetal Outcomes.

Background And Objective: Women with asthma should continue controller therapy during pregnancy, but current evidence on the effects of inhaled corticosteroids (ICS) and long-acting beta2-agonists (LABA) on adverse fetal outcomes remains unclear.

Methods: This was a population-based retrospective cohort study. Data were derived from the Health and Welfare Database, Birth Certificate Application, and Maternal and Child Health Database in Taiwan, from January 1, 2007 to December 31, 2018.

Harnessing Dynamic Heteroleptic Complexation for Self-Assembly of Robust Nested Metallo-Supramolecular Cages.

The exclusive formation of artificial multicomponent assemblies remains a significant challenge, in contrast to the well-established organization observed in natural systems, due to intrinsic entropic constraints. To overcome this limitation, recent efforts have been focused on developing precision self-assembly strategies for the rational construction of such architectures. Here, we construct an ideal complementary pair of 2,2':6',2″-terpyridine (tpy)-based ligands by fine-tuning the substituent bulkiness, which enables the quantitative formation of robust nested cages through efficient dynamic heteroleptic complexation with multivalent coordination.

Phase II Dose-Randomized Study of Sunvozertinib in Platinum-Pretreated Non-Small Cell Lung Cancer With Epidermal Growth Factor Receptor Exon 20 Insertion Mutations (WU-KONG1B).

Purpose: WU-KONG1B (ClinicalTrials.gov identifier: NCT03974022) is a multinational phase II, dose-randomized study to assess the antitumor efficacy of sunvozertinib in pretreated patients with advanced non-small cell lung cancer (NSCLC) with epidermal growth factor receptor () exon 20 insertion mutations (exon20ins).

Methods: Eligible patients with advanced-stage exon20ins NSCLC were randomly assigned by 1:1 ratio to receive sunvozertinib 200 mg or 300 mg once daily (200 and 300 mg-rand cohorts).