Rice Bran Extract Alleviates Inflammation and Promotes Wound Healing in Radiation Dermatitis.

Radiation dermatitis is a common side effect of radiotherapy, affecting up to 95% of cancer patients receiving radiation therapy and often leading to skin damage, inflammation, and ulceration. The pathogenesis of radiation dermatitis involves complex mechanisms, such as the production of reactive oxygen species (ROS) and sustained inflammatory responses. Current treatments, including topical steroids, moisturisers, and non-steroidal anti-inflammatory drugs (NSAIDs), often provide limited efficacy, primarily addressing symptoms rather than the underlying pathophysiological processes.

Treatment consequence and adverse events of cyclin-dependent kinase 4/6 inhibitors on patients with hormone receptor-positive, HER2-negative metastatic breast cancer: a systematic review and meta-analysis.

Background: Although some studies have indicated that CDK4/6 inhibitors are beneficial for the progression-free survival (PFS) and overall survival (OS) in breast cancer, evidence regarding the assessment of clinical response remains insufficient. Therefore, this study aims not only to evaluate the efficacy and safety of CDK4/6 inhibitors combined with endocrine therapy in HR(+)/HER2(-) metastatic breast cancer, but also to analyze the objective response rate (ORR) and clinical benefit rate (CBR), providing comprehensive clinical outcome insights.

Materials And Methods: A literature search was performed in PubMed, Embase, Cochrane Library, and ClinicalTrials.

eHealth Literacy Mediating Social Support and Technology Acceptance Among Patients With Chronic Illnesses: A Cross-Sectional Study.

Aim: To examine the relationships among social support, eHealth literacy and eHealth technology acceptance among patients with chronic illnesses, and investigate whether eHealth literacy plays a mediating role.

Design: A cross-sectional correlational study.

Methods: A total of 202 patients with chronic illnesses were recruited from outpatient clinics and communities in Taiwan.

Investigating the Effects of Different n-6 Polyunsaturated Fatty Acid Ratios on Ferroptosis in IPEC-J2 Cells.

Dietary n-6 and n-3 polyunsaturated fatty acid (PUFA) balance critically modulates various physiological processes, including inflammation and cell death. This study investigated the effects of different n-6 PUFA ratios (1:1, 5:1, 10:1, 20:1) on ferroptosis in porcine IPEC-J2 intestinal epithelial cells. Cells treated with varying PUFA ratios showed a significant reduction in cell viability, which was alleviated by the ferroptosis inhibitor ferrostatin-1 (fer-1).

Combining Erection Restoration and Factual Penile Enhancement Based on Revolutionary Penile Fibro-Vascular Assembly.

Objective: Conventional penile venous surgery for erection restoration and surgery for penile augmentation have been controversial. Based on de novo penile fibrovascular assembly, we report innovative penile venous stripping (PVS) and factual penile girth enhancement (FPGE).

Methods: From 2013 to 2023, refractory impotence and dysmorphia prompted 31 patients to seek PVS and FPGE, and all of them were confirmed with veno-occlusive dysfunction.

Thromboembolic safety and clinical benefits of tranexamic acid beyond hemostasis in post-COVID-19 patients undergoing major arthroplasty: A STROBE-compliant retrospective study.

The safety of tranexamic acid (TXA) in patients with recent coronavirus disease (COVID-19) infection undergoing major arthroplasty remains unclear. We aimed to evaluate whether TXA increases thromboembolic risk in post-COVID-19 patients undergoing major arthroplasty. Using the TriNetX database, we identified patients aged ≥50 years who underwent total knee or hip arthroplasty with documented COVID-19 within 3 months prior to surgery.

Protective effects of microalgal macular pigment on diabetic retinopathy upon blue light irradiation induced oxidative stress, inflammation, and MAPK pathways.

Microalgae and their rich nutrient content are increasingly recognized as a sustainable food source. Microalgal macular pigment (MP), composed of zeaxanthin and lutein, is densely concentrated in the retinal macula of eyes and is frequently utilized in eye health maintenance. However, as a sustainable food ingredient, the food safety and functionality of MP need further investigated.

Gastrointestinal stability and DPP-IV inhibitory activity of tilapia (Oreochromis niloticus) viscera hydrolysate-derived novel peptides LPCL and TPFLPDE, with LPCL-modulated GLP-1 and PepT1 expression in STC-1 cells.

Dipeptidyl-peptidase (DPP)-IV inhibition by penultimate N-terminus Pro-containing peptides is a promising strategy for Type 2 diabetes (T2D) management, as it prevents the degradation of incretin hormones (DPP-IV substrates) like glucagon-like peptide-1 (GLP-1), thereby prolonging their half-life. However, the stability and bio-accessibility of these peptides are crucial to their efficacy in orally administered therapeutics. We previously identified LPCL and TPFLPDE peptides from tilapia viscera by-products hydrolysates, which exhibited significant DPP-IV inhibition in vitro and in situ while effectively preserving active GLP-1 levels after 2 h treatment in STC-1 cells under basal glucose conditions.

Multiple large language models versus clinical guidelines for postmenopausal osteoporosis: a comparative study of ChatGPT-3.5, ChatGPT-4.0, ChatGPT-4o, Google Gemini, Google Gemini Advanced, and Microsoft Copilot.

Unlabelled: The study assesses the performance of AI models in evaluating postmenopausal osteoporosis. We found that ChatGPT-4o produced the most appropriate responses, highlighting the potential of AI to enhance clinical decision-making and improve patient care in osteoporosis management.

Purpose: The rise of artificial intelligence (AI) offers the potential for assisting clinical decisions.

Incidence, risk factors, prognosis of periprosthetic fractures post hip fracture: unveiling protective role of anti-osteoporotic medication.

Unlabelled: People with a hip fracture are prone to break the bone around the metal repair, causing severe health issues. This study found that initiating anti-osteoporotic medication soon after the first fracture halves that risk, highlighting the benefit of early osteoporosis treatment.

Background: Hip fractures pose significant clinical challenges, often leading to prolonged hospitalization, reduced quality of life, and increased risk of subsequent fractures.

Improving applications of a design-comparable effect size in single-case designs.

g is a design-comparable effect size that has been recommended by the What Works Clearinghouse since 2020 to assess an intervention effect in single-case studies and for meta-analyses. Yet, no research has systematically studied how g's performance could be impacted by its non-convergence, and how g's non-convergence and performance could be improved by increasing the case size (m) and measurement size (N). This study expanded on the work of Pustejovsky et al.

Developing Potent Therapeutics for Liver Cancer Chemoresistance via an RNA Nanotech and Series-Circuit-Christmas-Bulb Mechanism Targeting ABC Transporters.

Liver cancer, particularly hepatocellular carcinoma (HCC), poses significant treatment challenges due to chemoresistance and cancer recurrence. Similar to customs at the border, the liver detoxifies incoming chemicals via efflux pumps and overexpresses ATP-binding cassette (ABC) drug exporters, leading to chemoresistance. ABC contains a multihomosubunit structure and a revolving transport mechanism, actively effluxing drugs from cancer cells, thereby reducing intracellular drug accumulation and therapeutic efficacy.

Comparative performance of machine learning and conventional scoring systems for neuroprognostication in out-of-hospital cardiac arrest survivors.

Background: Accurately predicting the neurological outcomes in out-of-hospital cardiac arrest (OHCA) survivors is crucial. Conventional prediction scores should be validated across different settings. Additionally, machine learning (ML) models may provide improved predictive performance.

Internalized stigma and depressive severity in Taiwanese gay men: A moderated mediation model of resilience and positive identity.

Background: Internalized sexual stigma is a significant psychological stressor contributing to depression among gay men. While resilience and positive sexual identity are known protective factors, their combined roles remain understudied in non-Western contexts, particularly in East Asian societies like Taiwan.

Purpose: This study investigated whether resilience mediates and positive sexual identity moderates the association between internalized stigma and depressive severity among Taiwanese gay men.

When diagnostic clues are hidden in small blood vessels of the skin: Diagnostic challenge in Intravascular Large B-Cell Lymphoma.

Intravascular large B-cell lymphoma (IVLBCL) is a rare extranodal lymphoma characterized by selective growth of neoplastic lymphocytes within small vessels, and often lacking lymphadenopathy or circulating malignant cells. Its clinical heterogeneity and nonspecific symptoms frequently cause delayed diagnosis and treatment. We report 3 new cases in elderly patients presenting with unexplained anemia, systemic symptoms in 2 patients, and purpuric skin lesions in one patient.

Pathogen-Bound C-type Lectin and Ficolin Enhance Toll Receptor Signaling is activated through Spätzle1 Cleavage in response to White Spot Syndrome Virus (WSSV) in Penaeus monodon.

The dynamic interaction between immune recognition molecules and signaling pathways in the innate immune response of Penaeus monodon to White Spot Syndrome Virus (WSSV) infection is unveiled in this study. Through comprehensive gene expression profiling, we demonstrate significant upregulation of key immune genes, including a specific C-type lectin and a defined ficolin isoform, in WSSV-infected hemocytes, underscoring their pivotal roles in pathogen recognition and antiviral defense. Leveraging advanced molecular techniques, we successfully expressed, purified, and characterized these recombinant proteins, revealing their time-dependent expression and high-affinity binding to lipopolysaccharides (LPS).

Prognostic significance of estimated radiation dose to immune cells in cancer patients undergoing thoracic irradiation: A meta-analysis.

Background And Purpose: Emerging evidence suggests that excessive radiation dose to immune cells may impair host immunity and negatively affect cancer prognosis. However, the prognostic impact of the estimated radiation dose to immune cells across different cancer types and treatment modalities remains inconclusive. This meta-analysis aimed to systematically evaluate the association between estimated radiation dose to immune cells and survival outcomes in patients with lung and esophageal cancers undergoing radiotherapy.

Impact of Risk Factors and a New Transfer Pathway on Endovascular Thrombectomy Outcomes in Acute Ischemic Stroke.

Objective: Endovascular thrombectomy (EVT) is a time-critical therapy for acute ischemic stroke (AIS) caused by large vessel occlusion. To improve transfer efficiency, a web-based EVT transfer system was implemented in the Taiwan Stroke Network. This study evaluated its impact on workflow metrics and patient outcomes.

Air pollutants, temperature, and road traffic noise: their impact on chronic kidney disease incidence in older individuals in Taiwan.

Limited research has examined the relationships of co-exposure to air pollutants, temperature, and road traffic noise with chronic kidney disease (CKD) incidence and the interaction between PM and temperature. To address this gap, the present study explored these associations and interactions in Taiwan. A cohort of 3,041 older individuals (aged ≥55 years) was recruited in 2009 and followed until 2019.

The properties of Ocicmum gratissimum aqueous extract against ultraviolet-C-induced inflammation.

Ethnopharmacological Relevance: Ocimum gratissimum L. commonly known as basil, is an herb-like plant frequently mentioned in ethnopharmacological studies due to its widespread availability in local communities and its widespread use in treating inflammatory conditions. In a previous study, we demonstrated that aqueous extracts of Ocimum gratissimum (OGE), which are rich in plant polyphenols such as caffeic acid and isoflavones, can protect skin cells from UVC-induced inflammation and damage in migration and proliferation.

Dengue Epidemiology in 7 Southeast Asian Countries: 24-Year, Retrospective, Multicountry Ecological Study.

Background: Dengue fever remains the most significant vector-borne disease in Southeast Asia, imposing a substantial burden on public health systems. Global warming and increased international mobility may exacerbate the disease's prevalence. Furthermore, the unprecedented COVID-19 pandemic may have influenced the epidemiological patterns of dengue.

Evaluating the Preliminary Efficacy of the TRUST Intervention on Alone-Time and Communication During Well-Adolescent Visits: Quasi-Experimental Study.

Background: Alone time with health care providers is critical for adolescents, and several professional organizations recommend it. Alone time with providers promotes better utilization of health services, empowers adolescents to manage their health, and facilitates discussions on sensitive issues. However, only 40% of adolescents have private conversations with clinicians during visits.