Comparison of compressive forces generated by dynamic compression angle-stable interlocking nail versus traditional dynamic compression plate and locking compression plate.

The aim of this study was to compare the compressive forces generated by Dynamic Compression Angle-Stable Interlocking Nail (DCASIN) with those of traditional Dynamic Compression Plates (DCP) and Locking Compression Plates (LCP) using synthetic diaphyseal bone models (SDBM). Three groups were established based on the fixation method (G-DCASIN, G-DCP, and G-LCP), with implants fixed to SDBM simulating a transverse fracture, comprising 10 repetitions per group. A strain-gauge load cell was positioned in the SDBM gap to measure compressive forces in kilograms, recorded 30 s after the completion of each group-specific compression technique.

Association of Energy, Macronutrients, and Fiber Intakes with Bone Health in Adolescent Athletes.

This study investigated the association between energy and macronutrient intake and bone health in 63 adolescents of both sexes who participated in volleyball, track and field, or swimming. Bone mineral content (BMC) and density (BMD) of the total body less head (TBLH), lumbar spine (L1-L4), and femoral neck were assessed using DXA. Bone geometry parameters, including cross-sectional area (CSA), cross-sectional moment of inertia (CSMI), and section modulus, were estimated.

Effects of Lycopene Supplementation on Bone Tissue: A Systematic Review of Clinical and Preclinical Evidence.

: Bone tissue undergoes continuous remodeling, and imbalances in this process can lead to osteometabolic disorders, such as osteoporosis. Thus, bioactive compounds, like lycopene (LYC), have been investigated for their potential protective effects in bone health. This systematic review (SR) aimed to evaluate the effects of LYC supplementation on bone tissue.

In Vitro Proof-of-Concept Study: Lidocaine and Epinephrine Co-Loaded in a Mucoadhesive Liquid Crystal Precursor System for Topical Oral Anesthesia.

Local anesthesia is essential for most dental procedures, but its parenteral administration is often painful. Topical anesthetics are commonly used to minimize local anesthesia pain; however, commercial formulations fail to fully prevent the discomfort of local anesthetic injection. We developed and characterized a novel lidocaine and epinephrine co-loaded liquid crystalline precursor system (LCPS) for topical anesthesia.

A Systematic Review of Clinical and Experimental Periodontitis Studies Demonstrating the Expression of PPAR-Gamma: A Meta-Analysis and Bioinformatics Approach.

Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ) plays important anti-inflammatory roles, including in periodontitis. This systematic review with a meta-analysis compiles evidence on the transcriptional and translational levels of PPAR-γ in clinical and experimental periodontitis studies, alongside functional enrichment and PPAR-γ interaction network analyses. Electronic searches were conducted in six databases for publications up to February 2024.

Integrative Analysis of Differentially Expressed miRNAs and Noncoding RNA Networks Reveals Molecular Mechanisms Underlying Metritis in Postpartum Dairy Cows.

Postpartum metritis in dairy cows compromises reproductive performance and leads to substantial economic losses. This study investigated the molecular mechanisms underlying metritis by integrating high-throughput circulating microRNA (miRNA) profiling with systems-level bioinformatics. Previously, 30 differentially expressed miRNAs, 16 upregulated and 14 downregulated, were identified in metritis-affected cows compared to healthy controls.

Biofilm development in three-dimensional models infected with .

Dermatophytes are keratinophilic filamentous fungi that cause dermatophytosis, and the main etiological agents can be anthropophilic and zoophilic. Several virulence factors are involved in the pathogenesis of dermatophytosis, including the formation of fungal biofilms. In this context, three-dimensional (3D) models, such as spheroids and reconstructed human skin (RHS), have gained prominence, as they more accurately emulate fungus-host interactions, closely resembling physiological conditions.

Molecular Impacts of Occupational Exposure to Waste Anesthetic Gases.

Millions of healthcare professionals are occupationally exposed to waste anesthetic gases (WAGs) worldwide; however, their effect on DNA methylation is unknown. Thus, for the first time, global DNA methylation analysis was performed in addition to the comet assay and gene expression analysis in this case-control study to reveal possible molecular alterations associated with WAG exposure. A total of 86 participants were included (43 healthcare professionals exposed to WAGs and 43 matched-controls).

Efficacy and effects on enamel of low and high-concentrated bleaching gels for at-home and in-office techniques.

Purpose: To evaluate the efficacy of low and high-concentrated bleaching gels in both at-home and in-office techniques and their effects on enamel properties.

Methods: Bovine enamel/dentin specimens were randomly allocated to five groups (n=12): deionized water (negative control - DW), 6% hydrogen peroxide (6HP), 40% hydrogen peroxide (40HP), 10% carbamide peroxide (10CP), and 45% carbamide peroxide (45CP). For 6HP and 40HP, the gel was applied 3x20 minutes in 1 day.

Bleaching with biocatalysts and violet LED: a randomized clinical trial using a hybrid design with parallel-group and split-mouth approaches : Violet LED and biocatalysts in in-office whitening: a split-mouth trial.

Objective: To compare conventional 35% hydrogen peroxide whitening for 45 min with test therapies lasting 15 min using a polymeric scaffold, peroxidase, and violet LED.

Materials And Methods: Sixty patients were randomized into three groups (n = 20): TC45 (35% HP for 45'), T15 (35% HP for 15'), and TT (polycaprolactone scaffold + 35% HP with peroxidase for 15'). One hemiarch was irradiated with violet LED (L) (8 cycles of 1 min, with 30-second intervals).

Assessment of a microhaplotype panel for human identification and ancestry inference in Brazil.

Microhaplotypes (MHs) comprise multiple single nucleotide polymorphisms (SNPs) in DNA segments of up to 300 bp in length. These SNP combinations result in numerous allelic variations (i.e.

A call to standardize the nomenclature of human fetal membrane at the feto-maternal interface.

Despite being one of the largest intrauterine tissues in surface area, the fetal membrane that lines the intrauterine cavity is often overlooked, forgotten, or misidentified in clinical and basic science research. The feto-maternal interface is comprised of the fetal membrane (fetal component) and decidua parietalis (maternal component), which lines the intrauterine cavity and provides essential mechanical, immune, hormonal, and transport support to maintain pregnancy. Fetal membrane plays an important role in triggering and regulating labor via complex signaling cascades.

Social Isolation Induces Sex-Differentiated Sensory-Emotional Pain Responses and Oxytocinergic Receptors Alterations in Mice.

Background: Chronic pain is a global health problem frequently associated with psychopathologies such as anxiety and depression, with a higher prevalence in women. However, most of the preclinical studies have used male animals as experimental subjects, highlighting the importance of studies that consider sex as a biological factor modulating the responses related to chronic pain. The experience of high social stress can maintain and exacerbate chronic pain.

Healthcare costs according to obesity and physical activity: 8-year longitudinal study among patients assisted by the Brazilian National Healthcare System.

Introduction: Obesity is a risk factor for the development of many chronic diseases, and, consequently, it is associated with an increase in the use of health services. On the other hand, practicing physical activity reduces healthcare costs. However, the long-term roles of physical activity and obesity in healthcare costs are not well explored in the literature.

Influence of Axial and Angled Implants on Marginal Bone Loss in All-on-Four Implant-Supported Rehabilitation: A Retrospective Cohort Study.

Objectives: The aim of this study was to compare marginal bone loss levels between axially and angled installed implants in maxillary rehabilitation utilizing the All-on-Four concept, while also examining the impact of terminal cantilever size on implant/prosthesis set survival.

Materials And Methods: This retrospective cohort study involved 11 patients (44 implants) who received implant-supported prostheses with immediate loading. Radiographic evaluations were conducted on the day of prosthesis delivery, including panoramic and periapical radiographs, establishing the baseline (T0).

A new synthetic peptide GA-KKALKKLKKALKKAL-CONH exhibits antiviral activity against ZIKV in multiple stages of the replicative cycle.

Zika virus (ZIKV) is an emerging arbovirus, and its infection is often asymptomatic or mild; however, it can lead to severe neurological disorders. Currently, there are no approved treatments or vaccines for ZIKV, highlighting the urgent need to explore potential therapeutic options. In this study, we evaluated the antiviral activity of a novel synthetic peptide (GA-peptide) against ZIKV in vitro.

Regulatory RNA Networks in Ovarian Follicular Cysts in Dairy Cows: Implications for Human Polycystic Ovary Syndrome.

: Ovarian follicular cysts (OFCs) in dairy cows represent a significant cause of infertility and share striking similarities with polycystic ovary syndrome (PCOS) in women. This study aimed to elucidate the molecular mechanisms underlying OFCs and their relevance to PCOS by profiling differentially expressed (DE) microRNAs (miRNAs) and constructing integrative RNA interaction networks. : Expression analysis of 84 bovine miRNAs was conducted in antral follicular fluid from normal and cystic follicles using miScript PCR arrays.

In Vivo Assessment of Trimetaphosphate Nanocomposite-Based Polyamide-6 Scaffolds Enhanced With Silver Nanoparticles for Bone Regeneration.

The aim of this study was to evaluate the influence of nanocomposite materials, specifically sodium trimetaphosphate (TMP) nanoparticles decorated with 2.5% silver nanoparticles (AgNP), incorporated into polyamide-6 (Pa6) polymeric matrices on bone repair in surgically created critical-size defects in rat calvaria. Eighteen male Wistar rats were divided into three groups based on the treatment received: control group (C)-blood clot; Pa6-AgNP; and Pa6-TMP-AgNP.

Achieving Functional and Aesthetic Harmony Through a Fully Digital Workflow for Lateral Agenesis Rehabilitation: A 12-Month Follow-Up.

Objective: Digital technologies are revolutionizing dentistry by introducing advanced methods that enhance treatment planning and execution. In complex cases, these innovations improve communication among interdisciplinary teams and streamline workflows for more personalized and efficient care. This case report demonstrates the aesthetic and functional rehabilitation of a patient with agenesis of lateral incisors, smile asymmetry, and facial skeletal discrepancies, using an integrated digital approach.

Surveying coating strategies for peri-implantitis management: Clinical implications and classificatory approaches.

Background: Peri-implantitis, an inflammatory condition occurring in the supportive tissues, is triggered by a dysbiotic biofilm that grows on implant and/or abutment surfaces. Consequently, the entire surface becomes a notorious culprit, fostering bacterial adhesion that might lead to progressive loss of supporting bone. To combat peri-implantitis, research groups worldwide have diligently pursued the development of new antimicrobial coatings.

Dietary Phosphorus Requirement for Tambaqui, Colossoma macropomum, in the Grow-Out Phase.

Phosphorus is essential for fish growth as it is crucial in skeletal development and metabolic reactions. The dietary requirement for this mineral varies among fish species and growth stages. Therefore, the objective of this study was to determine the available phosphorus (AP) requirement for tambaqui during the grow-out phase (± 400 to 1000 g) using growth parameters, whole-body macronutrient composition, whole-body, scales, and bone mineral content, biochemical blood parameters, and activity of antioxidant enzymes as response parameters.

Clinical Significance and Prognostic Value of TLR4 and AGER in Inflammatory Breast Cancer.

: Inflammatory breast carcinoma (IBC) is an aggressive and rare neoplasm, accounting for 1-5% of all breast cancers. Toll-like receptor type 4 (TLR4) and Advanced Glycation End Products Receptor (AGER/RAGE) have been implicated in breast cancer, and have been shown to promote tumor growth, metastasis, and resistance to therapy by modulating the tumor microenvironment and inflammatory pathways. However, the role of TLR4 and AGER in IBC has not been elucidated.

Primary Health Care Costs Associated With Trajectories of Physical Activity Over 10 Years.

Background: The aim of this study was to investigate whether health care costs were influenced by trajectories of physical activity (PA) over a 10-year period.

Methods: Five hundred and forty-one users of primary health care services in Brazil were followed from 2010 to 2020. PA (questionnaire) was assessed every 2 years.

Phage display-derived peptides as molecular probes for predicting Staphylococcal Exfoliative Toxin-Desmoglein 1 interactions.

Staphylococcal exfoliative toxins (ETs) are serine proteases that cleave desmoglein 1 (Dsg1), a protein critical for epidermal integrity, leading to severe skin conditions. While the specificity of ETs for Dsg1 has been partially studied, the molecular determinants of ET-Dsg1 recognition remain unclear. In this study, we used phage display biopanning and computational modeling to map the interaction between ETs and Dsg1.