Clinical Significance and Prognostic Value of TLR4 and AGER in Inflammatory Breast Cancer.

: Inflammatory breast carcinoma (IBC) is an aggressive and rare neoplasm, accounting for 1-5% of all breast cancers. Toll-like receptor type 4 (TLR4) and Advanced Glycation End Products Receptor (AGER/RAGE) have been implicated in breast cancer, and have been shown to promote tumor growth, metastasis, and resistance to therapy by modulating the tumor microenvironment and inflammatory pathways. However, the role of TLR4 and AGER in IBC has not been elucidated.

Primary Health Care Costs Associated With Trajectories of Physical Activity Over 10 Years.

Background: The aim of this study was to investigate whether health care costs were influenced by trajectories of physical activity (PA) over a 10-year period.

Methods: Five hundred and forty-one users of primary health care services in Brazil were followed from 2010 to 2020. PA (questionnaire) was assessed every 2 years.

Phage display-derived peptides as molecular probes for predicting Staphylococcal Exfoliative Toxin-Desmoglein 1 interactions.

Staphylococcal exfoliative toxins (ETs) are serine proteases that cleave desmoglein 1 (Dsg1), a protein critical for epidermal integrity, leading to severe skin conditions. While the specificity of ETs for Dsg1 has been partially studied, the molecular determinants of ET-Dsg1 recognition remain unclear. In this study, we used phage display biopanning and computational modeling to map the interaction between ETs and Dsg1.

Anti-erosive effect of fluoride solutions associated with methacrylate polymer: A randomized crossover in situ study.

Objectives: To evaluate the anti-erosive effect of solutions containing fluoride and aminomethacrylate copolymer associations on enamel and dentin, using a randomized crossover in situ model.

Methods: Bovine enamel and dentin specimens were fixed in intraoral devices. Participants (n = 12) installed the devices and rinsed with seven experimental solutions in a randomized sequence, with 2-day washout between them: Ultrapure water-C; Sodium fluoride-F (225 ppmF-); Stannous Chloride-Sn (800 ppm Sn2+); Aminomethacrylate- AA (2 %); FSn; F+AA; FSn+AA.

Comparative evaluation of heating instruments for detecting HF183, SARS-CoV-2, and Aichi virus A in untreated wastewater using colorimetric LAMP.

This study assessed the accuracy, field suitability, and cost-effectiveness of colorimetric LAMP (c-LAMP) assays using six heating instruments: Electric Kettle, Water Bath, Heating Block, miniPCR, Thermocycler, and Genie® III. Bacteroides HF183 (HF183), SARS-CoV-2, and Aichi virus A (AiV-A) were tested using control materials and wastewater samples, comparing cLAMP with qPCR/RT-qPCR detection. qPCR/RT-qPCR reliably detected HF183 and AiV-A genetic fragments at dilutions as low as 1 × 10 pg/μL, corresponding to 1.

Establishing a Dual Murine Model to Explore the Interactions Between Diabetes and Periodontitis in Mice.

This study aimed to develop and validate a dual murine model integrating a high-fat diet (HFD) and a single streptozotocin (STZ) dose to induce diabetes mellitus (DM), alongside periodontitis (Perio) induced by ligature placement and oral inoculation with (). The goal was to mimic human pathological conditions, creating a physiologically relevant environment to study the interplay between DM and Perio. A total of 128 six-week-old male C57BL/6J mice were randomly divided into four groups: Control, DM, Perio, and DM-P.

Impact of SGLT2i on Cardiac Remodeling and the Soleus Muscle of Infarcted Rats.

Unlabelled: Skeletal muscle changes occur in heart failure (HF). Despite the cardioprotective effects of sodium-glucose co-transporter 2 (SGLT2) inhibitors in HF, their impact on skeletal muscle remains poorly understood. We investigated the effects of the SGLT2 inhibitor empagliflozin (EMPA) on cardiac remodeling and the soleus muscle of rats with myocardial infarction (MI)-induced HF.

Intake of Pyriproxyfen Through Contaminated Food by the Predator Navás, 1911 (Neuroptera: Chrysopidae): Evaluation of Long-Term Effects on Testes via Transcriptome Analysis.

Understanding the sublethal effects of insecticides on non-target insects is essential for integrated pest management (IPM). This study aimed to evaluate the differentially expressed genes (DEGs) in the testes of adults exposed to pyriproxyfen during the larval stage. Larvae (0-12 h) were fed eggs treated with pyriproxyfen (50 and 100 mg a.

Characterization of Biofilm Formation by the Dermatophyte .

Dermatophytosis is a fungal infection that affects the skin, hair, and nails, impacting approximately 25% of the global population. is a geophilic fungus that can cause infections in humans and animals. Several studies have been conducted regarding its virulence, or ability to cause disease.

Immunotherapy for the Treatment of Atherosclerotic Disease: Integrative Review.

Immunotherapy, especially monoclonal antibodies, has shown efficacy in modulating the inflammatory response and controlling lipidic pathways, offering new approaches for treating atherosclerotic disease. This article reviews the scientific evidence on the use of therapeutic monoclonal antibodies in treating atherosclerotic disease. An integrative review was carried out using the protocol Whittemore and Knafl framework and the PRISMA 2020 guidelines for systematic reviews.

Influence of different post estropausal models on dental socket repair, bone metabolism, and antioxidant capacity of C57Bl/6 J mice.

The objective was to analyze and compare the influence of different post estropausal models on dental socket repair, bone metabolism and antioxidant capacity of mice. 46 C57BL/6 J mice were divided in the following groups: NC (negative control)-no treatment, OVX-SHAM-sham ovariectomy, OVX-ovariectomy, VCD-medicated with 160 mg/kg/day of 4-vinylcyclohexene diepoxide via IP, and aged-post-estropausal. After persistent diestrus, they underwent extraction of the upper right incisor, euthanized after 7 and 21 days for microCT, histopathology, birefringence, immunohistochemistry, and biochemical analysis of bone and antioxidants markers.

Cashew () nut co-product in extruded foods for dogs.

Cashew nut is a co-product of the cashew () industry, with high fat (40%) and protein (23%) contents. During processing, the nuts can break down, generating the cashew nut granules (CNG). Considering the effort for rational use of food resources, the present study investigated the use of CNG as an ingredient in extruded dog diets.

Establishment of Cell Cultures from the Cavefish Astyanax mexicanus: A Resource for in vitro Studies of Supernumerary B Chromosome Biology.

Introduction: Supernumerary B chromosomes have been extensively investigated using diverse in vivo approaches, revealing insights into their origin, nature, evolutionary dynamics, maintenance mechanisms, and effects on their carriers. Despite its broad applicability across various biological research fields, in vitro cell culture remains underexplored as a tool for studying B chromosome biology, with studies limited to using cell cultures only as a source of chromosome preparations.

Methods: In the present study, cell cultures of the fish Astyanax mexicanus were established, with (AMEcfB) and without (AMEcf) the B chromosome, using caudal fin tissue collected through nonlethal procedures.

Synergistic effect of aminomethacrylate copolymer and fluoride in toothpastes against erosive tooth wear.

Objective: To evaluate the protective potential of fluoride toothpaste formulations associated with aminomethacrylate copolymer (AMC) against enamel initial erosion and erosive tooth wear.

Material And Methods: Polished bovine enamel specimens were divided into six groups (n = 13): placebo toothpaste (PL), AMC toothpaste (AMC 4 %), sodium fluoride toothpaste (F, 1450 ppm F), AMC+NaF toothpaste (AMC+F), abrasion negative control (ANC - ultrapure water with abrasion), and erosion negative control- (ENC - ultrapure water without abrasion). Specimens underwent erosive/abrasive cycling, which included 0.

Clinical outcomes of tibial tuberosity transposition with a controlled translation device for the treatment of patellar luxation in dogs: fifteen surgeries on 14 cases (2021-2022).

Objectives: The aim of this study was to evaluate the efficacy and outcomes of the tibial tuberosity transposition technique modified using a slow and controlled translation device (mTTT), in dogs with patellar luxation. The technique seeks to realign the quadriceps extensor mechanism using a dedicated device for tibial tuberosity transposition.

Materials And Methods: Fourteen dogs with grade II medial patellar luxation were included in the study, and 15 stifles were treated using this technique.

Antitumor Effect of Curcumin, D6 Turmeric, and Hydrochloride Mitoxantrone on Canine and Human Urothelial Cancer Cells.

Bladder urothelial carcinoma (UC) is an aggressive malignancy in both humans and dogs, with limited treatment options. Owing to their biological and environmental similarities with humans, dogs serve as a valuable model for UC research. Standard treatments, including surgery, chemotherapy, and anti-inflammatory agents, have shown limited efficacy.

in the Planting Furrow of Sugarcane to Minimize the Use of N Fertilizer.

Sugarcane ( spp.) stands out in the context of sustainable agricultural production due to its versatility and energy potential. However, management challenges, such as nitrogen (N) fertilization associated with microbiological action, require improvement.

Influence of Thickener and Mineral Supplementation of Bleaching Gels on Enamel Demineralization.

Objective: This study evaluated the effect of the type of thickener and mineral supplementation of bleaching gels on enamel demineralization.

Materials And Methods: Enamel specimens were divided into five groups according to the type of thickener: CA-Carbopol, AE-Aerosil 200, PO-Poloxamer 407, GG-Guar gum, and HEC-Hydroxyethyl cellulose. Each group was subdivided into three subgroups according to the level of mineral supplementation: none, saturation concentration, and maximum addition.

Assessment of the impact of biodegradable lignin nanoparticles encapsulating IAA on tomato development: from seed to fruit.

Polymeric nanoparticles have emerged as promising nanocarriers for plant growth regulators (PGRs) in agriculture, enhancing plant growth and boosting fruit and cereal yields. Among these, lignin nanoparticles (LNPs) stand out due to their biodegradability and low production cost. However, few studies have evaluated the biological effects of LNPs encapsulating PGRs - particularly their dose-dependent impacts across the entire plant life cycle.

Total sodium replacement by calcium in trimetaphosphate and its incorporation into dental whitening gels: A novel strategy for in-office treatment.

Objectives: The aim of this study was to synthesize a cyclophosphate with total sodium replacement (CaTMP) and to evaluate, in vitro, its incorporation into hydrogen peroxide (HP) whitening gels.

Materials And Methods: CaTMP was synthesized through column chromatography using ion-exchange resin and calcium hydroxide solution. Bovine enamel/dentin discs (n = 150) were divided into five groups: 1) negative control (no treatment), 2) 35 % HP whitening gel (positive control), 3) 35 % HP + 1 % CaTMP, 4) 17.

ZnO Nanorod/Ag NanoparticleFunctionalized Paper Substrate for Sensitive SERS Detection of Environmental Contaminants.

In this work, we functionalize Whatman no 1 paper (WP) substrates with zinc oxide nanorods (ZnO NRs) decorated with silver nanoparticles (AgNPs) for detecting environmental contaminants. ZnO NRs were grown by hydrothermal synthesis assisted by microwave irradiation on WP substrate and subsequently decorated with AgNPs using the dewetting deposition method. WP substrates functionalized with ZnO NRs/AgNPs were used as a SERS platform for detecting rhodamine 6G (R6G) dye and the thiabendazole (TBZ) pesticide, widely used in modern agriculture for fungal disease protection in fruits and vegetables.

Anti-Inflammatory Properties of Yellow Passion Fruit Bagasse Extract and Its Potential Role in Periodontal Wound Healing In Vitro.

: Periodontal disease involves chronic immunoinflammatory processes and microbial dysbiosis, making phytochemicals with anti-inflammatory properties potential therapeutic agents. This study aimed to assess the modulatory effects of yellow passion fruit bagasse extract (PFBE) on periodontal cells under microbial condition. : A human periodontal ligament (PDL) cell line was exposed to ATCC 25586 to simulate a microbial environment in vitro in the presence and absence of PFBE containing three different concentrations (0.

Effect of Quercetin-Doped Hydrogen Peroxide Gels on Enamel Properties: An In Vitro Study.

This in vitro study evaluated the effects of incorporating quercetin (QC) at varying concentrations (0.25%, 0.5%, and 1%) into a 35% hydrogen peroxide (HO) bleaching gel on esthetic outcomes, enamel hardness and roughness, and HO transamelodentinal diffusion.