Phage display-derived peptides as molecular probes for predicting Staphylococcal Exfoliative Toxin-Desmoglein 1 interactions.

Staphylococcal exfoliative toxins (ETs) are serine proteases that cleave desmoglein 1 (Dsg1), a protein critical for epidermal integrity, leading to severe skin conditions. While the specificity of ETs for Dsg1 has been partially studied, the molecular determinants of ET-Dsg1 recognition remain unclear. In this study, we used phage display biopanning and computational modeling to map the interaction between ETs and Dsg1.