Clinical Efficacy of Er,Cr:YSGG Laser for Deepithelialization of Free Gingival Grafts in Gingival Recession Treatment: A Randomized, Split-Mouth Clinical Trial.

: The deepithelialized free gingival graft (DGG) technique provides high-quality connective tissue grafts (CTGs) with predictable outcomes for recession coverage. This study evaluates a novel method of free gingival graft (FGG) deepithelialization using an Er,Cr:YSGG laser (LDEE) for treating multiple gingival recessions. : A split-mouth study was conducted on 46 ( = 46) recessions in nine patients (23 per test and control group).

Pulsed electromagnetic field therapy on nonsurgical treatment of peri-implantitis: 12-26 months follow-up.

Background: Pulsed electromagnetic field (PEMF) therapy, renowned for its immunomodulatory effects and established efficacy in orthopedics, shows promise for managing peri-implantitis by reducing soft tissue inflammation and marginal bone loss. This study aimed to compare the long-term clinical and radiographic outcomes of nonsurgical peri-implantitis treatment with and without PEMF therapy. This multicenter retrospective-prospective analysis combined data from two centers.

Surveying coating strategies for peri-implantitis management: Clinical implications and classificatory approaches.

Background: Peri-implantitis, an inflammatory condition occurring in the supportive tissues, is triggered by a dysbiotic biofilm that grows on implant and/or abutment surfaces. Consequently, the entire surface becomes a notorious culprit, fostering bacterial adhesion that might lead to progressive loss of supporting bone. To combat peri-implantitis, research groups worldwide have diligently pursued the development of new antimicrobial coatings.

Enhanced collagenogenesis on three-dimensionally printed titanium surfaces by human gingival fibroblasts: An in vitro study.

The lack of cementum in peri-implant tissues leads to a deficiency in anchorage points for gingival collagen fibers. This arrangement is linked to reduced protective capabilities compared to teeth. Therefore, there is a pressing need to develop surfaces that optimize the interaction between soft tissue and implants.

Engineered surface strategies to manage dental implant-related infections.

When exposed to the oral environment, dental implants, like natural surfaces, become substrates for microbial adhesion and accumulation, often leading to implant-related infections-one of the main causes of implant failure. These failures impose significant costs on patients, clinicians, and healthcare systems. Despite extensive research, there is no consensus on the most effective protocol for managing peri-implantitis.

5-Aminolevulinic Acid Gel Associated with Light-Emitting Diode Modulates the Subgingival Multispecies Oral Biofilm.

This study assessed the impact of a 5% combination of 5-aminolevulinic acid (5-ALA) (Aladent) in a multispecies in vitro biofilm model subgingival pathogens. The 33-species biofilm model was established in the Calgary Biofilm Device during a duration of 7 days. The biofilm treatments comprised various groups: control, light-emitting diode (LED), Aladent (ALADA), and Aladent with LED (ALAD+L), administered on day 6.

3D-Printed Rehabilitation and Immediate Loading in a Completely Edentulous Patient With Computed Guided Surgery: A Case Report With a 24-Month Follow-Up.

Implant-supported fixed rehabilitations are a reliable solution to restore aesthetics and function to edentulous patients. Currently, practitioners can use digital flow with computer-aided design & computer-aided manufacturing (CAD/CAM) technology to enhance their productivity by reducing working time and providing more comfort to patients. This report presents a clinical case in which the digital flow was used to restore the inferior edentulous arch in a 55-year-old female patient with an implant-based Misch's FP3 denture.

Effect of smoking over one pack daily on implant healing and health: A cohort study.

Background: This prospective cohort trial examines the effects of heavy smoking on peri-implant marginal bone loss (MBL) and implant survival rates over 15 months.

Methods: Thirty subjects, categorized as either smokers (more than 20 cigarettes daily for over 5 years) or non-smokers, were initially recruited with pocket depths ≤ 5 mm and at least one missing tooth. Urine cotinine assay was used to confirm smoking status.

Can combination syndrome influence functional performance and peri-implant bone remodeling in mandibular overdenture users? Results from a 5-year cohort study.

Purpose: This longitudinal clinical study aimed to investigate the circumferential peri‑implant bone level (CPBL), posterior mandibular resorption (PMR), and masticatory function (MF) in users of implant-retained mandibular overdentures (IMOs), comparing individuals with and without combination syndrome (CS) over a 5-year follow-up period.

Materials And Methods: A total of 39 patients were enrolled and stratified into two groups: absence of CS (ACS; n = 23) and presence of CS (PCS; n = 16). Assessments were conducted at 1, 3, and 5 years.

Systemic Ozone Therapy Improves Oral Hard and Soft Tissue Healing in Medication-Related Osteonecrosis of the Jaw (MRONJ): A Study in Senescent Female Rats.

: Medication-related osteonecrosis of the jaw (MRONJ) is a challenging condition often associated with bisphosphonate use, leading to impaired bone healing and difficult clinical management. Given the lack of predictable therapeutic options, this study investigated the effects of systemic ozone therapy on MRONJ healing. This study aimed to analyze the effects of systemic ozone therapy on oral hard and soft tissue healing in senescent rats with medication-related osteonecrosis of the jaw (MRONJ) induced by antiresorptive therapy.

Tackling Microbial Contamination in Polydioxanone-Based Membranes for Regenerative Therapy: Bioengineering an Antibiotic-Loaded Platform.

Barrier membranes are essential components of tissue regenerative therapies, acting as physical barriers to protect the healing site. Although collagen-based membranes are widely used, they degrade enzymatically, often triggering inflammation and cytotoxicity arising from residual cross-linking agents. Synthetic polymer-based membranes, such as polydioxanone (PDO), present customizable properties, predictable degradation rates, and induce bone formation more effectively.

Effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on the volumetric contraction of post-extraction sockets: a double-blinded randomized controlled clinical trial.

Objective: This study aimed to evaluate the effect of recombinant human bone morphogenic protein type-2 (rhBMP-2) on the alveolar ridge in the post-extraction socket in humans.

Method And Materials: 20 subjects with 25 teeth of the maxilla were included (11 sockets in the control [blood clot] and 14 in the test group [rhBMP-2]). The teeth were minimally and traumatically extracted.

Brazilian red propolis as a potential antimicrobial additive in orthodontic primers.

This study evaluated the effect of adding ethanolic extract of red propolis (EERP) on antimicrobial activity, polymerization kinetics (PK), degree of conversion (DC), and shear bond strength (SBS) of the orthodontic adhesive system. Transbond XT Primer was the control group (G1). The experimental adhesives contained 3.

Stability of soft tissue augmentation at implant site using volume-stable collagen matrix: 2-year retrospective study.

Objective: To evaluate the long-term dimensional stability of dental ridges 2 years after soft tissue augmentation using a porcine-derived volume-stable collagen matrix (VCMX) at healing abutment connections.

Method And Materials: A retrospective study was conducted at a private clinic from 2021 to 2023, involving 13 patients who underwent delayed single implant placement in both maxillae and mandible. Three months after implant placement, the buccal soft tissue adjacent to the abutment was augmented with VCMX.

Microbiome modulation of implant-related infection by a novel miniaturized pulsed electromagnetic field device.

Dental implant-related infections, which lack effective therapeutic strategies, are considered the primary cause for treatment failure. Pulsed electromagnetic field (PEMF) technology has been introduced as a safe and effective modality for enhancing biological responses. However, the PEMF effect on modulating microbial diversity has not been explored.

Volumetric Evaluation of Alveolar Ridge Preservation Using Dense PTFE (d-PTFE) Membranes Intentionally Exposed to the Oral Cavity After Immediate Implant Placement-A Retrospective Study.

Tooth loss causes alveolar bone resorption, which may hinder the ability of implant placement. Socket preservation with immediate implant placement is one of the methods used to reduce bone resorption. In this retrospective study, we evaluated the influence of the use of dense polytetrafluoroethylene (d-PTFE) membranes on alveolar preservation after tooth extraction and with the installation of immediate dental implants.

Next-Generation Dental Materials: Exploring Bacterial Biofilm Formation on 3D-Printable Resin-Based Composites.

This study evaluated the microbial growth profile of subgingival multispecies biofilm on 3D-printable resin-based composites (PRBCs). A 96-well cell plate cultivated a 39-species biofilm associated with periodontitis over 7 days. Cylindrical specimens with 12 mm high and 3 mm diameters were prepared by the PRBC group (Cosmos Temp-Yller; Prizma 3D Bio Crown; Prizma 3D Bio Prov) and an acrylic resin as control.

Osteoporosis' effects on dental implants osseointegration and survival rate: a systematic review of clinical studies.

Objectives: The goal of this systematic review was to critically appraise the existing evidence evaluating osteoporosis' effects on dental implant osseointegration and survival rate.

Data Source: A search was conducted in two databases, PubMed/MEDLINE and Scopus, until October 2024, using the keywords 'osteoporosis,' 'osteopenia,' 'osseointegration,' and 'dental implants'. The inclusion criteria were clinical studies that evaluated the implant placement, complications, and osseointegration results in patients with osteoporosis; literature reviews and clinical studies addressing the outcome were considered; and articles written in English and published since 2000.

Platelet-rich fibrin obtained from different protocols affects the formation of the multispecies subgingival biofilm associated with periodontitis.

Background: The aim of this article is to evaluate the effect of different portions of Platelet Rich Fibrin (PRF) membranes and liquid-PRF, prepared by two distinct protocols/centrifuges each, on the multispecies subgingival biofilm.

Materials And Methods: PRF membranes and liquid-PRF were prepared using two protocols: centrifuge 1 uses fixed acceleration while centrifuge 2, progressive acceleration. PRF samples were introduced into device concurrently with 33-species bacterial inoculum.

Evaluation of Peri-Implantitis through Fourier-Transform Infrared Spectroscopy on Saliva.

Background: Peri-implantitis is characterized as a pathological change in the tissues around dental implants. Fourier-transform infrared spectroscopy (FTIR) provides molecular information from optical phenomena observed by the vibration of molecules, which is used in biological studies to characterize changes and serves as a form of diagnosis.

Aims: this case-control study evaluated the peri-implant disease by using FTIR spectroscopy with attenuated total reflectance in the fingerprint region.

Effects of Platelet-Rich Fibrin on Bone Healing Around Implants Placed in Maxillary Sinuses: A Histomorphometric Assessment in Rabbits.

This study investigated the effect of platelet-rich fibrin (PRF) on bone healing around implants placed in elevated sinus cavities. Forty New Zealand albino rabbits were divided into eight groups, based on the time of sacrifice (14 or 40 days) and the material used: blood clot (control), hydroxyapatite (HA) from bovine bone, HA combined with PRF, and PRF alone. Each group consisted of five animals (n = 5).

Is There an Ideal Concentration of Ozonized Oil for the Prevention and Modulation of Zoledronate-Induced Mandibular Osteonecrosis? A Study on Senescent Rats.

This study aimed to identify whether there is an ideal concentration for applying ozonized oil (OZ) in the post-exodontic alveoli of senescent rats treated with zoledronate (ZOL). Thirty-five female rats, aged 18 months, were divided into five groups: ZOL; ZOL+OZ500; ZOL+OZ600; ZOL+OZ700; and SAL. The groups treated with ZOL, and other concentrations of OZ received applications at a dose of 100 μg/kg, while the SAL group received saline.

The Effect of a Nature-Based Gel on Gingival Inflammation and the Proteomic Profile of Crevicular Fluid: A Randomized Clinical Trial.

Evidence has shown the clear positive effects of nature-based products on biofilm control and improved gingival health. However, most studies have used in vitro models, have tested single natural components, or have not evaluated proteomic changes after treatment. This double-blind, parallel, randomized, and controlled clinical trial evaluated the benefits of a nature-based gel in controlling gingival inflammation and its effects on the proteomic gingival crevicular fluid (GCF) profile.

The Impact of Nutritional Components on Periodontal Health: A Literature Review.

Periodontitis is a chronic inflammatory disease driven by the accumulation of bacterial plaque and the host's immune response, leading to the destruction of periodontal tissues. Nutrition, particularly the intake of micronutrients with anti-inflammatory and antioxidant properties, plays a crucial role in maintaining periodontal health. This review explores the impact of various micronutrients-vitamins (A, B, C, D, E), minerals (calcium, iron, zinc, potassium, copper, manganese, selenium), and omega-3 fatty acids-on periodontal disease prevention and management.