The Hypoxia-Induced Chromatin Reader ZMYND8 Drives HIF-Dependent Metabolic Rewiring in Breast Cancer.

Breast cancer, a leading cause of mortality, exhibits significant heterogeneity across molecular subtypes, with tumor hypoxia contributing to poor therapeutic outcomes. The present study investigates the role of ZMYND8, a hypoxia-responsive epigenetic factor, in regulating carbohydrate metabolism in concert with HIF1α in breast cancer. In adherent cells as well as in 3D MCTS, ZMYND8 expression is elevated under hypoxic conditions.

Search for a Neutral Gauge Boson with Nonuniversal Fermion Couplings in Vector Boson Fusion Processes in Proton-Proton Collisions at sqrt[s]=13 TeV.

The first search for a heavy neutral spin-1 gauge boson (Z^{'}) with nonuniversal fermion couplings produced via vector boson fusion processes and decaying to tau leptons or W bosons is presented. The analysis is performed using LHC data at sqrt[s]=13  TeV, collected from 2016 to 2018 with the CMS experiment and corresponding to an integrated luminosity of 138  fb^{-1}. The data are consistent with the standard model predictions.

Pd-Lined Strained Trimetallic Au-Ag-Pd Nanoprism for Enhanced Electrocatalytic Activity Towards Formic Acid Oxidation.

Formic acid oxidation (FAO) reaction is an important electrocatalytic reaction in low-temperature proton exchange membrane fuel cells. Pd-based material has a superior electrochemical activity towards FAO. The activity of Pd-based bimetallic materials is also well-studied in the literature.

Classical annealing of the Sherrington-Kirkpatrick spin glass using Suzuki-Kubo mean-field Ising dynamics.

We propose and demonstrate numerically a fast classical annealing scheme for the Sherrington-Kirkpatrick (SK) spin glass model, employing the Suzuki-Kubo mean-field Ising dynamics (supplemented by a modified Thouless-Anderson-Palmer reaction field). The resultant dynamics, starting from any arbitrary paramagnetic phase (with local magnetizations m_{i}=±1, for the ith spin, and the global magnetization m=0), takes the system quickly to an appropriate state with small local values of magnetization (m_{i}) commensurate with the (frustrated) interactions. As the temperature decreases with the annealing, the configuration practically remains (in an effective adiabatic way) close to a low-energy configuration as the magnitudes of m_{i}'s and the spin glass order parameter q grow to unity.

Flat or crumpled: States of active symmetric membranes.

We set up and study the hydrodynamic theory for inversion-symmetric active fluid and tethered membranes. For some choices of the activity parameter, such membranes are stable and described by linear hydrodynamic equations, which are exact in the asymptotic long wavelength limit, giving stable flat phases with translational quasi-long-range orders. For other choices of the activity parameter, the system is linearly unstable in the long wavelength limit, implying crumpling, or has intermediate wave-vector instabilities, suggesting patterns.

Rough or crumpled: Strong coupling phases of a generalized Kardar-Parisi-Zhang surface.

We study a generalized Kardar-Parisi-Zhang (KPZ) equation [Jana et al., Phys. Rev.

Two-Dimensional Electron Gases Formed in Strain-Engineered Ferroelectric SrTiO Thin Films.

Two-dimensional electron gases (2DEGs) in quantum paraelectric SrTiO (STO) exhibit high electron mobilities at low temperature, superconductivity, and efficient spin-charge interconversion owing to their Rashba spin-orbit coupling. However, such 2DEGs have almost exclusively been generated in STO single crystals, and few attempts to replace crystals by heteroepitaxial STO films have mostly resulted in low mobilities, limiting device integration and functional tuning such as strain-induced ferroelectricity. Here, we use hybrid oxide molecular beam epitaxy to grow high-quality strain-engineered STO films that are ferroelectric up to 165 K.

Liquid-liquid phase separation of lamin drives altered chromatin organization in cardiomyopathic mutations of lamin A.

Lamins are intermediate filaments constituting the nuclear lamina which maintains the structural integrity of the nucleus and play a key role in the spatiotemporal genome organization. Mutations in lamin A/C have been associated with a plethora of diseases including dilated cardiomyopathy. In this study, we focused on lamin A mutants E161K and K97E which are widely reported in patients afflicted with dilated cardiomyopathy.

Manganese-Doped Zinc-Mediated Assembly of Gold Nanoclusters as a Dual-Emitting Fluorescent Probe for Surface-Controlled Ratiometric Detection of Biothiols in Complex Biofluids.

We developed a ratiometric fluorescent probe using zinc-mediated assemblies of Mn-doped gold nanoclusters for the sensitive detection of biologically relevant thiols. Thiol binding selectively enhanced the nanoclusters's emission at 477 nm, while Mn emission at 570 nm remained unaltered, enabling precise ratiometric sensing. The probe showed performance in complex media, like blood serum, and showed high selectivity, with no allied response to non-thiol analogues.

Effect of Variation of Spatial and Temporal Frequencies of the Moving Field Visual Stimulus on Optokinetic Response of Adult Zebrafish.

The optokinetic response (OKR) is a reflexive behavior in which the eye intends to fixate the surrounding image in motion on its retina. The two important components of the OKR visual stimulus are the spatial frequency (SF) and the temporal frequency (TF). Zebrafish () is considered an important model animal for visual physiology research.

Search for Quasiparticle Scattering in the Quark-Gluon Plasma with Jet Splittings in pp and Pb-Pb Collisions at sqrt[s_{NN}]=5.02 TeV.

The ALICE Collaboration reports measurements of the large relative transverse momentum (k_{T}) component of jet substructure in pp and Pb-Pb collisions at center-of-mass energy per nucleon pair sqrt[s_{NN}]=5.02  TeV. Enhancement in the yield of such large-k_{T} emissions in head-on Pb-Pb collisions is predicted to arise from partonic scattering with quasiparticles of the quark-gluon plasma.

Absorption of Fermionic Dark Matter in the PICO-60 C_{3}F_{8} Bubble Chamber.

Fermionic dark matter absorption on nuclear targets via neutral current interactions is explored using a nonrelativistic effective field theory framework. An analysis of data from the PICO-60 C_{3}F_{8} bubble chamber sets leading constraints on spin-independent absorption for dark matter masses below 23  MeV/c^{2} and establishes the first limits on spin-dependent absorptive interactions. These results demonstrate the sensitivity of bubble chambers to low-mass dark matter and underscore the importance of absorption searches in expanding the parameter space of direct detection experiments.

The impact of ER on mitochondrial integrity mediated by PDK4.

ER and mitochondrial stress are often interconnected and considered major contributors to aging as well as neurodegeneration. Coordinated induction of ER and mito has been observed in diabetes and pulmonary disorders. However, in the context of aging and neurodegeneration, regulation of this intra-organellar crosstalk has remained relatively elusive.

LncRNAOmics: A Comprehensive Review of Long Non-Coding RNAs in Plants.

The large portion of the eukaryotic genomes was considered non-functional and called the "dark matter" of the genome, now appearing as regulatory hubs coding for RNAs without the potential for making proteins, known as non-coding RNA. Long non-coding RNA (lncRNA) is defined as functional RNA molecules having lengths larger than 200 nucleotides without the potential for coding for proteins. Thousands of lncRNAs are identified in different plants and animals.

Isomerization of Methylhydroxycarbene in Isolation and Mediated by Its Interactions with Ammonia and Formic Acid.

Computational chemistry is used to examine the unimolecular isomerization kinetics of isolated methylhydroxycarbene (MHC) and compare with that of its catalyzed bimolecular isomerization in the presence of ammonia (NH) and formic acid (FA) over the 180 K-380 K temperature range. The two catalysts, one being a base and the other being an acid, both exhibit hydrogen bonding. For all the three processes studied, the potential energies along the reaction path are calculated at the CCSD(T)/6-311++G(3df,3pd)//M06-2X/6-311++G(3df,3pd) level.

Crystallization of Low-Dimensional Lead-Free (R/S-MBA)CuBr Chiral Perovskite Thin Films.

Low-dimensional halide perovskites with chiral organic spacer cations possess unique properties that are appealing for next-generation optoelectronic and spintronic applications. However, a complete understanding and effective control over the thin-film crystallization kinetics of these materials have not yet been established. Here, we unravel a plausible diffusion-controlled crystallization mechanism with spontaneous nucleation for lead-free (R/S-MBA)CuBr thin films by estimating the Avrami exponent, ≈ 0.

Profiling Hinge Plasticity in Intact Monoclonal Antibodies for Antigen Recognition.

Monoclonal antibodies (mAbs) are multidomain glycosylated proteins that mediate antigen binding, among other protein-protein interactions, which makes them successful therapeutics. However, in many cases, adverse physicochemical properties can affect their antigen-binding abilities, compromising therapeutic potential. Hence, structural characterization of these biotherapeutics is strongly desired to predict and possibly redesign better variants.

Naphthalene Diimide-Based Soft Materials Exhibiting High-Performance, Tunable Electrical Properties Through Side-Chain Engineering and Strong Binding Interactions with Human Hemoglobin.

Herein the design and synthesis of naphthalene diimide (NDI) derivatives aminated at the core with N,N-dimethylpropane-1,3-diamine, and 6-aminocoumarin are reported. Accommodating amine substituents on the electron-poor NDI scaffold yielded notable electronic characteristics of interest. These aminated NDIs exhibited two distinct absorption bands: one at a high-energy band (350-450 nm) associated with π-π transitions and the other one (450-600 nm) due to intramolecular charge transfer absorption.

Imprinting Electrically Switchable Scalar Spin Chirality by Anisotropic Strain in a Kagome Antiferromagnet.

Topological chiral antiferromagnets, such as MnSn, are emerging as promising materials for next-generation spintronic devices due to their intrinsic transport properties linked to exotic magnetic configurations. Here, it is demonstrated that anisotropic strain in MnSn thin films offers a novel approach to manipulate the magnetic ground state, unlocking new functionalities in this material. Anisotropic strain reduces the point group symmetry of the manganese (Mn) Kagome triangles from C to C, significantly altering the energy landscape of the magnetic states in MnSn.

Enhancing FRET Efficiency through Synergistic Influences of Surfactants and Quantum Dots on Zinc Quinolate Complex-Dye Interactions.

Herein, we present a pioneering approach to enhancing Förster resonance energy transfer (FRET) efficiency through the synergistic integration of cetyltrimethylammonium bromide (CTAB) surfactants and ZnS quantum dots (QDs) within a zinc quinolate complex (ZQC)-dye (Rhodamine B: RhB) system. FRET efficiency is elevated from 13.1% to 49% with surfactants alone and further to an impressive 93.

Presence of a Spatially Varying Electric Field at the Lipid-Water Interface with a Na:K Ratio in Water.

We investigated ion-lipid interactions in dipalmitoylphosphatidylcholine (DPPC) Langmuir monolayers exposed to mixed K/Na solutions at varying ratios (K:Na = 0:100 to 100:0). Tensiometric studies of water, i.e.

Unveiling Synergistic Effectiveness of Strategically Designed Cobalt Clusters for Efficient Water Electrolysis.

Electrocatalytic water splitting is a challenging step toward hydrogen production to mitigate fossil fuel dependence. In nature, water oxidation is catalyzed by the MnCaO cluster in photosystem-II, but the design of synthetic molecular catalysts still remains a challenge. A few catalysts with low-cost abundant cobalt metal ions have been previously reported, although with low durability and high overpotentials.

Does Excellence Correspond to Universal Inequality Level?

We study the inequality of citations received for different publications of various researchers and Nobel laureates in Physics, Chemistry, Medicine and Economics using Google Scholar data from 2012 to 2024. Citation distributions are found to be highly unequal, with even greater disparity among Nobel laureates. Measures of inequality, such as the Gini and Kolkata indices, emerge as useful indicators for distinguishing Nobel laureates from others.

Androgen receptor plays critical role in regulating cervical cancer cell migration.

Cervical cancer (CC) is the second most common cancer among women in India and the fourth worldwide. While major genes and pathways have been studied, further research is needed to identify newer candidates for targeted therapy in metastatic disease. This study used a graph-theory-based network analysis to identify important interacting proteins (IIPs) with maximum connectivity, high centrality scores, and significant global and local network perturbation scores.