Manganese-Doped Zinc-Mediated Assembly of Gold Nanoclusters as a Dual-Emitting Fluorescent Probe for Surface-Controlled Ratiometric Detection of Biothiols in Complex Biofluids.

We developed a ratiometric fluorescent probe using zinc-mediated assemblies of Mn-doped gold nanoclusters for the sensitive detection of biologically relevant thiols. Thiol binding selectively enhanced the nanoclusters's emission at 477 nm, while Mn emission at 570 nm remained unaltered, enabling precise ratiometric sensing. The probe showed performance in complex media, like blood serum, and showed high selectivity, with no allied response to non-thiol analogues.

Four orders-of-magnitude enhancement in the two-photon excited photoluminescence of homoleptic gold thiolate nanoclusters following zinc ion-induced aggregation.

Herein we report unprecedented determination of the molar mass of zinc mediated assemblies of homoleptic gold nanoclusters, based on charge detection mass spectrometry measurements. The accurate determination of the molar mass of zinc coordinated assemblies of gold clusters has further allowed unambiguous determination of the two-photon excited photoluminescence cross section of the same. Furthermore, in line with one-photon excited photoluminescence measurements, four orders-of-magnitude enhancement in two-photon excited photoluminescence of gold nanoclusters has been observed following complexation with zinc ions.

Tailoring the luminescence of atomic clusters via ligand exchange reaction mediated post synthetic modification.

The growing prominence of atomic nanoclusters in fields of practical relevance has made modulation of their luminescent characteristics an important challenge for their future applications. Herein we report chemical reaction assisted modulation of luminescence of histidine stabilized gold nanoclusters via a ligand exchange reaction with cysteine. Upon addition of 3.