Characteristics and Risk Factors of Medication Incidents Across Stages of Medication Management in Residential Aged Care: A Longitudinal Cohort Study of 5700 Reported Incidents.

Background: Problems with medication management are consistently identified as key concerns for the quality of residential aged care (RAC). Incident reports can provide valuable information on key issues related to medication management; however, few studies have explored medication incidents in RAC settings.

Objectives: To investigate the characteristics of medication incidents at different stages of medication management and identify the risk factors associated with incidents.

The emerging roles of long non-coding RNAs in the nervous system.

Tens, if not hundreds, of thousands of long non-coding RNAs (lncRNAs) are transcribed from mammalian genomes, especially in the brain, wherein most exhibit region-specific and/or cell-specific expression patterns. Many lncRNAs are nuclear-localized and appear to be the products of developmental enhancers, whereas others are found in the cytoplasm, including at the synapse. Here, we describe the lncRNAs that have been shown to have roles in various aspects of brain development, synaptic function, learning, behaviour and brain disorders.

Barriers and enablers to hearing service provision in aged care settings in Australia: perspectives from hearing clinicians.

Objective: To explore the barriers and enablers hearing clinicians face providing services for people in home and residential aged care settings in Australia.

Design: Semi-structured interviews were conducted using the Capability, Opportunity, Motivation Behaviour model (COM-B). Deductive and inductive qualitative analysis were applied using Braun and Clarke's method.

Glycyrrhetinic acid functionalized polyamidoamine dendrimers for targeted gene delivery in liver cancer.

Gene therapy holds significant promise for the treatment of liver cancer. However, the development of safe and efficient gene delivery systems remains a critical challenge. Cationic polymers are widely utilized as gene carriers due to their high transfection efficiency, yet their application is often hindered by cytotoxicity and lack of target specificity.

Trait-based island biogeography as a tool for studying future ecological communities.

Understanding the future of ecological communities under global change is among the most pressing challenges in plant ecology. Islands, with their reduced species diversity and clear boundaries, have been central in developing ecological theories and have served as valuable ecological models. But islands are also important in themselves, supporting unique diversity and acting as species refugia.

Clinical psychedelic research in adolescents: a scoping review and overview of ethical considerations.

The potential use of psychedelic-assisted therapy for adolescents with mental illness has sparked both interest and concern. Modern psychedelic research has focused on adults, and adolescents younger than 18 years are typically excluded due to ethical and legal challenges. To explore whether adolescents have been included in 21st century psychedelic research, we conducted a scoping review of the medical literature from January, 2000, to April, 2025.

Sensorimotor contingencies in congenital hearing loss: The critical first nine months.

In the recent two decades it became possible to compensate severe-to-profound hearing loss using cochlear implants (CIs). The data from implanted children demonstrate that hearing and language acquisition is well-possible within an early critical period of 3 years, however, the earlier the access to sound is provided, the better outcomes can be expected. While the clinical priority is providing deaf and hard of hearing children with access to spoken language through hearing aids and CIs as early as possible, for most deaf children this access is currently in the second or third year of life.

Effects of age, sex, language ability and second language listening on children's recognition of nonwords and sentences in noise and reverberation.

Objectives: To evaluate children's ability to recognise speech and its relationship to language ability using two newly developed tests: the Listening in Spatialised Noise and Reverberation test (LiSN-R) and the Test of Listening Difficulties - Universal (ToLD-U).

Design: LiSN-R and ToLD-U used nonword and sentence recognition in spatially separated noise and reverberation. Language ability was assessed using the Clinical Evaluation of Language Fundamentals (CELF) sentence recall.

A parasitic or mutualistic conundrum: can symbiotic protists increase thermal tolerance in a semi-aquatic insect?

Rising temperatures and frequent heatwaves pose a major threat to ectotherms due to their reliance on environmental temperature for physiological processes. Thermal tolerance, the ability to withstand varying temperature, determines how effectively and efficiently individuals can survive under extreme conditions. Host-microbial symbiotic interactions can influence thermal tolerance in insects; however, we have limited information especially for some endosymbionts such as gregarines, a group of apicomplexan endoparasites, which are commonly found in the guts of many aquatic and terrestrial insects.

Effects of nurse-led, web-based brief behavioral therapy on insomnia severity in patients in the chronic stage of stroke recovery: a preliminary randomized controlled trial.

Study Objectives: Insomnia is prevalent among stroke survivors in the chronic stage of stroke. However, effective interventions remain limited. This study examined the effects of nurse-led, face-to-face, and web-based brief behavioral therapy for insomnia (BBTI) compared with sleep hygiene education (SHE) on sleep outcomes in stroke survivors.

Implementation of a digital coordination centre in a hospital: a qualitative evaluation of enablers, barriers and strategies.

Background: Digital Coordination Centres (DCCs) represent an innovative approach in hospital settings, designed to enhance patient flow, operational efficiency, and real-time decision-making. While their potential is widely recognised, there is limited understanding of the factors influencing their implementation. This study evaluated the implementation of a DCC in a large Australian hospital, with a focus on identifying enablers, barriers, and strategies for improvement.

Response to biologics along a gradient of T2 involvement in patients with severe asthma: a data-driven biomarker clustering approach.

Background: Asthma with low levels of T2-biomarkers is poorly understood.

Objective: To characterize severe asthma phenotypes and compare pre- to post-biologic change in asthma outcomes along a gradient of T2-involvement.

Methods: This was a registry-based, cohort study including data from 24 countries.

Australian Implementation of the Teaching Personal and Social Responsibility Pedagogical Model in Physical Education: Protocol for a Nonrandomized Controlled Trial.

Background: Interventions targeting the psychomotor domain of learning have been the most dominant in the physical education (PE) discipline. However, as PE also incorporates a holistic perspective of student development, a gap has emerged where interventions targeting social outcomes are not frequently analysed. Social outcomes have been of particular interest for interventions conducted in PE.

Change in the prevalence of creaky voice over time in Australian English.

Creaky voice is a linguistic feature that is perceived to have increased in prevalence in English over recent years, particularly in women's speech. However, there is limited empirical evidence for this apparent increase. Using real-time acoustic analysis, we explore whether generational change in creaky voice prevalence can be seen among teenage speakers from Sydney, Australia.

Asthenospheric flow and lithospheric erosion driving the outward growth of the northeastern Tibetan Plateau.

The northeastern (NE) Tibetan Plateau is extruding eastward at a rapid rate (∼15 mm a), but the role of the upper mantle in this process remains unclear. Early-Miocene primary melilitites from the leading edge of the extruding plateau provide critical insights into the upper mantle dynamics. Geochemical and Sr-Nd-Pb-Os isotopic data, supported by experimental melt comparisons, reveal that these melilitites originate from a hybrid source of CO-bearing mantle source, probably dominated by peridotite and pyroxenite/wehrlite lithologies.

Uniform Safety and Excellent Performance of Pressure-Regulated Deployment of Transcatheter Aortic Valves.

•Pressure-regulated deployment (PRD) results in consistent and excellent transcatheter aortic valve (TAV) performance.•PRD produces superior valve hemodynamics in patients with small aortic annuli.•PRD mitigates the risk of annular injury even among patients at high anatomic risk.

Challenges and complications of trans-osseous carpal tenodesis for scapholunate ligament tears.

Scapholunate (SL) instability remains a challenging condition with significant possibility of implications for wrist function and long-term outcomes. This review explores the limitations and complications of current trans-osseous scapholunate ligament (SLL) reconstruction techniques, focusing on isometric reconstruction challenges and complications, for example osteonecrosis, tunnel fractures, graft failure, and iatrogenic extrinsic ligament injuries. Through biomechanical analysis and clinical case reviews, we demonstrate that the conventional three-ligament tenodesis (3LT) scaphoid tunnel has high risk of resulting in a non-isometric volar scapho-trapezial (vST) ligament reconstruction, potentially exacerbating carpal instability.

Thirty-Day And One-Year Outcomes Of Navitor Transcatheter Aortic Valve In Low- or Intermediate-Risk Patients.

Background: The Navitor transcatheter aortic valve is a self-expanding, intra-annular valve indicated for patients with severe aortic stenosis (AS) at high or extreme surgical risk.

Objectives: To assess the safety and effectiveness of the Navitor valve in severe AS patients at low or intermediate surgical risk.

Methods: VANTAGE is a prospective, single-arm, multicenter study.

Utilization of Biospecimens as a Biobank Output for Biomedical Research-A Report from the ISBER Annual Meeting 2024 Annual Meeting Roundtable Discussions.

Despite widespread recognition of the need to increase sample utilization, the utilization rate of collected biospecimens for research is still low. In recent years, funders have shifted priorities towards supporting biobanks/collections with high utilization. Given the imperative to upscale sample utilization, a roundtable was held to discuss the considerations for maximizing and measuring the utilization of biospecimens and the output models that biobanks can employ to ensure greater impact and directly attributable advancements in medical science.

Age-related changes in susceptibility to false memories in different tasks.

We become increasingly susceptible to various false memories as we age. Recent work has shown that in younger adults, associations between false memories in different paradigms are weak or non-existent. However, it is unknown whether the relationship between false memories changes for older adults.

Functional Magnetic Resonance Imaging (fMRI) Signatures of Progression and Phenoconversion in Prodromal Synucleinopathies.

Background: Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is a prodromal manifestation of synucleinopathies and provides a critical window to identify early markers of progression to Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Time-averaged (static) and time-varying (dynamic) functional connectivity between large-scale brain networks may sensitively capture early pathophysiological changes and offer prognostic value beyond structural imaging.

Objectives: To use functional magnetic resonance imaging (fMRI) on a longitudinal iRBD cohort to assess alterations in static and dynamic functional connectivity and explore their relationship with disease conversion and regional neurotransmitter density.

The acquisition of plain-emphatic consonant contrasts by Arabic-speaking children: An acoustic study.

Arabic emphatic consonants are claimed to be late-acquired, likely due to their motoric complexity, involving both coronal and pharyngeal/uvular constrictions. Children's production has largely been studied using impressionistic data, with limited acoustic analysis. This study acoustically examines the acquisition of emphatic consonants in Saudi-Hijazi Arabic-speaking children aged 3-6 years.

Assessing Language Skills as a Predictor of Children's Listening Difficulties: Validation and Reference Data on a New Auditory Language Task.

Objectives: Some children experience greater listening difficulties in noisy and reverberant environments than their peers, despite having normal peripheral hearing. In these cases, other potential causes have to be explored. One is a language disorder.