Effectiveness of the SHARE Approach for Improving Clinician Shared Decision Making Skills: A Trial in 12 Practices Located in Colorado, USA.

Background: The SHARE Approach Model and training curriculum was developed by the Agency for Healthcare Research and Quality (AHRQ) to teach clinicians practicing in diverse settings how to engage in more effective Shared Decision Making (SDM).

Objective: To determine the effectiveness of the SHARE Approach at improving SDM in practices located across Colorado, USA.

Design: A longitudinal study with pre- and post-intervention observations.

Reproductive technology's animal unconscious: multispecies motherhood and humanimal horror.

Preclinical animal testing has played a critical role within medical history. Yet it remains an underdiscussed topic within the medical humanities. What might happen, then, if we analyse the animal studies of the lab via the method of cultural critique that is animal studies? This essay responds to this question by exploring the roles that animals play, and are made to play, within the technologies for, debates about and narratives of human reproduction.

The role of the insula in the Takotsubo Cardiomyopathy: a scoping review.

Takotsubo Cardiomyopathy (TC) is a transient cardiomyopathy secondary to emotional and/or physical stress. While its precise aetiology remains unclear, some evidence suggests a possible role for the insular cortex (IC), which modulates cardiovascular responses to stress. The IC is a key viscerosensory and visceromotor hub with widespread connections, and is implicated in interoceptive processing, emotional regulation, and autonomic control.

Impact of DNA damage repair alterations on real-world response to therapy in metastatic colorectal cancer.

Background: Alterations in DNA damage repair (DDR) pathway genes can be exploited by cytotoxic chemotherapy regimens that induce DNA damage. Platinum chemotherapy has been shown to be particularly effective in DDR-mutated populations. However, the clinical impact of DDR mutations in metastatic colorectal cancer is still unknown.

Global Research Trends in EV-Based Cell-Free Therapy for Osteoarthritis: A Bibliometric Analysis.

Background: Osteoarthritis (OA) represents a major global health challenge with no ideal treatment options available. Early-stage treatment typically focuses on symptomatic relief of pain and stiffness; while late-stage patients can only opt for surgical interventions such as joint replacement to improve quality of life. Cell-free therapy based on extracellular vesicles (EVs) has offered a novel therapeutic approach for regulating bone metabolism and repairing cartilage, demonstrating emerging potential.

Organelle biology: When endolysosomes turn melanogenic.

Maintaining organelle identity and function relies on endomembrane system specialization and plasticity. A recent study uncovers endolysosomes as an alternative site of melanin production when melanosome biogenesis is impaired, revealing unexpected functional flexibility within the endolysosomal system.

Isolation and characterization of potentially ochratoxigenic fungi from Costa Rican coffee (Coffea arabica L.) beans.

Coffee plants and beans are prone to fungal contamination that pose health risks to consumers by producing mycotoxins like ochratoxin A (OTA). Thus, the present study aimed to analyze the mycobiota of Costa Rican coffee beans, focusing on potentially ochratoxigenic species and their in vitro susceptibility patterns to antifungal agents. Fungal isolates were obtained from cherry, green, and roasted coffee beans from Costa Rica; they were identified by morphology, MALDI-TOF technology, and sequencing.

Impact of Serum/Xeno-Free Medium and Cytokine Supplementation on CAR-T Cell Therapy Manufacturing in Stirred Tank Bioreactors.

Chimeric antigen receptor T-cell (CAR-T) therapies have demonstrated clinical efficacy in treating haematological malignancies, resulting in multiple regulatory approvals. However, there is a need for robust manufacturing platforms and the use of GMP-aligned reagents to meet the clinical and commercial demands. This study investigates the impact of serum/xeno-free medium (SXFM) and cytokine supplementation on CAR-T cell production in static and agitated culture systems, using 24-well plate G-Rex vessels and 500 mL stirred tank bioreactors (STRs), respectively.

Global anaesthesia practice using inguinal hernia surgery as a tracer condition: a secondary analysis of an international prospective cohort study.

Introduction: Restoration of surgical capacity is essential to post-COVID-19 recovery. This study explored the use and safety of anaesthesia options for inguinal hernia surgery, a common tracer condition, to describe current global practice and highlight opportunities to build the capacity of health systems.

Methods: This is a secondary analysis of an international prospective cohort study of consecutive patients who underwent elective inguinal hernia surgery.

Phase II Dose-Randomized Study of Sunvozertinib in Platinum-Pretreated Non-Small Cell Lung Cancer With Epidermal Growth Factor Receptor Exon 20 Insertion Mutations (WU-KONG1B).

Purpose: WU-KONG1B (ClinicalTrials.gov identifier: NCT03974022) is a multinational phase II, dose-randomized study to assess the antitumor efficacy of sunvozertinib in pretreated patients with advanced non-small cell lung cancer (NSCLC) with epidermal growth factor receptor () exon 20 insertion mutations (exon20ins).

Methods: Eligible patients with advanced-stage exon20ins NSCLC were randomly assigned by 1:1 ratio to receive sunvozertinib 200 mg or 300 mg once daily (200 and 300 mg-rand cohorts).

Perioperative Evaluation and Risk Stratification of the Elderly Patient Undergoing Vascular Intervention.

The surgical management of elderly patients has become increasingly important as the population ages in the U.S. and globally, and the incidence of cardiovascular risk factors continues to rise.

The Italian validation of the Watson Caritas Co-Worker Score for nurses and health care professionals.

Purpose: To translate, adapt, and validate the Watson Caritas Co-Worker Score in Italian.

Design: A cross-sectional study was conducted with 182 nurses and healthcare professionals.

Methods: Content Validity and construct validity, with Cronbach's alpha (α) and test-retest Intraclass Correlation Coefficients (ICCs), were calculated to assess validity and reliability.

The association between intrinsic capacity and functional ability in older adults - exploring the role of the physical environment.

Background: Ageing in place has been promoted in the Netherlands to encourage optimal functional ability (FA) and independent living among older adults. FA is likely dependent on intrinsic capacity (IC), a composite measure of an individual's mental and physical capacities-and its interaction with the physical environment in which people live. This study aimed to examine the association between IC and FA, as well as to explore how the physical environment may modify this relationship in older adults.

Hyponatremia and bone pathophysiology: An integrated preclinical and clinical perspective.

Chronic hyponatremia is increasingly recognized as a potential contributor to impaired bone health, although the underlying pathophysiological mechanisms have not yet been fully elucidated. Experimental studies have demonstrated that low serum sodium levels affect both osteoclast and osteoblast function, resulting primarily in increased bone resorption and secondarily in reduced bone formation. In humans, however, evidence regarding the effects of hyponatremia on bone remains limited.

Influence of nursing students' perceptions of clinical instructor caring on their professional values.

Background: Caring is an integral part of the nursing profession. The standards that guide nurses when caring for patients are the professional values which are learned throughout the career. In this process of learning, clinical instructors might play an important role since they have been identified as powerful role models for their students.

Application of computer vision for automated detection of different lesions in pig lungs: An exploratory study.

Accurate classification of lung lesions at necropsy is crucial for guiding the diagnostic process and ensuring effective management of porcine respiratory diseases. Post-mortem inspection of the lungs during slaughter also provides valuable insights into disease occurrence, offering useful feedback on the efficacy of on-farm prevention and control strategies. However, manual assessment protocols may be impaired by high slaughtering speeds and low inter-rater agreement, which limits continuous data collection and hinders comparability.

Can Machine Learning predict therapeutic outcomes in affective and not affective psychosis? A systematic review and meta-analysis.

Machine learning (ML) could be useful in identifying reliable predictors of treatment response in affective and not affective psychoses, potentially helping to propose personalized interventions. In this systematic review and meta-analysis, we evaluated studies exploiting ML algorithms to predict the improvement of psychotic symptoms, cognition and quality of life in psychoses related to different treatments. We searched MEDLINE (PubMed), Web of Science, and PsycINFO databases updated until February 2024, identifying 64 articles published in English in peer-reviewed journals.

THE CARDIOVASCULAR IMPACT OF CHRONIC VENOUS DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS.

Objective: To systematically evaluate the association between chronic venous disease (CVD) and cardiovascular (CV) risk, including major cardiovascular events and traditional risk factors, across diverse populations and study designs.

Methods: A systematic review was conducted following PRISMA guidelines. PubMed, Scopus, and Web of Science were searched from January 2011 to March 2025 using MeSH terms and free-text keywords.

Chronic Ocular Surface Pain: An Optometrist and Ophthalmologist Survey.

Introduction: Chronic ocular surface pain (COSP) is defined as ocular pain that is perceived to originate from the ocular surface and persists for more than 3 months. Clear epidemiological data on COSP prevalence are lacking.

Methods: In 2025, a total of 100 eye care providers were surveyed, including 50 optometrists and 50 ophthalmologists.

Efficacy of Stereotactic Ablative Body Radiotherapy (SABR) in uncommon subtypes of primary kidney cancer: An analysis from the International Radiosurgery Oncology Consortium of the Kidney.

Background: While stereotactic ablative body radiotherapy (SABR) is associated with excellent local control for primary renal cell carcinoma (RCC), outcomes based on clear-cell (ccRCC) and non-clear cell (nccRCC) histologies are not well defined.

Methods And Materials: Individual data of adult patient with biopsy confirmed primary RCC receiving SABR between 2007 and 2021 from 16 institutions in Australia, Canda, Germany, Japan and USA pooled. Patients with metastatic disease or upper tract urothelial carcinoma were excluded.

A Decade of Interactive Educational Exchange: Impacting Interprofessional Palliative Care Education.

The interprofessional clinical practice model is arguably the most impactful and generative aspect of hospice and palliative care (HPC) clinical practice. This article describes the innovative shared interprofessional leadership model, andragogical infrastructure, program development, educational impact, and critical lessons from the Interactive Educational Exchange (IEE). In response to a deficit in interprofessional HPC educational opportunities for rapid scholarship dissemination and mentorship, interprofessional leaders from medicine, social work and nursing proposed and implemented the IEE at the Annual Assembly of Hospice and Palliative Care presented by the American Academy of Hospice and Palliative Medicine and Hospice and Palliative Nurses Association from 2010-2020.