Repurposing Biomolecules from Against DDX3X in LAML: A Computer-Aided Therapeutic Approach.

Acute Myeloid Leukemia (LAML) is a life-threatening hematological malignancy, and the DEAD-box helicase 3 X-linked () gene is a potential yet underexplored target gene for LAML. Biomolecules derived from medicinal plants like offer a great source of therapeutic candidates. This study aimed to investigate the role of in LAML and identify plant-derived biomolecules that could inhibit using computational approaches.

A two-hit model in biliary atresia: cooperative viral-bacterial activation of MMP7 via TLR4/NF-κB signaling.

Rhesus rotavirus (RRV) infection primes biliary epithelial cells to respond hyperactively to low-dose lipopolysaccharide (LPS), triggering upregulation of matrix metalloproteinase-7 (MMP7) via TLR4/NF-κB signaling. Loss of endotoxin tolerance in biliary atresia (BA), associated with reduced expression of IRAK-M, leads to uncontrolled inflammation and tissue damage. MMP7 acts as a dual-function molecule, contributing to both extracellular matrix remodeling and amplification of inflammatory signaling in BA.

On the solutions of fractional differential equations with modified Mittag-Leffler kernel and Dirac Delta function: Analytical results and numerical simulations.

In this paper we define, for the first time, the modified fractional derivative with Mittage-Leffler kernel of Riemann-Liouville (R-L) type of arbitrary order [Formula: see text]delta. We derive the infinite series representations for the modified derivatives of R-L and Caputo types and present a relationship between them. We also investigate the modified derivatives for the Dirac delta functions, and study related fractional differential equations.

Fractional analysis of Benjamin-Bona-Mahony equation across natural transform iterative method: thermal engineering implementations.

In this study, we apply the Natural Transform Iterative Method (NTIM), a relatively new and efficient analytical tool for solving fractional differential equations (FDEs). NTIM combines the Natural Transform and Daftardar-Jafari polynomials to construct approximate solutions without the need for discretization, small parameters, or linearization. This method is particularly effective for handling fractional partial differential equations due to its simplicity and rapid convergence.

Anti-Inflammatory Activity of Sarcoaldosterol A Isolated From Heteroxenia fuscescens: Insights From In Vitro, In Silico, and Spectroscopic Studies.

Chronic inflammation is a key factor in the progression of many diseases, driving ongoing efforts to identify new and effective anti-inflammatory agents. Sarcoaldosterol A, a polyhydroxylated gorgostane steroid isolated from Heteroxenia fuscescens, was evaluated for its anti-inflammatory activity using in vitro studies, molecular docking, and quantum chemical calculations. Its structure was elucidated on the basis of 1D NMR, HR-ESI-MS, and comparison with literature.

Mathematical insights into epidemic spread: A computational and numerical perspective.

This study aims to investigate and analyze the dynamics of diarrhea infectious disease model. For this purpose, a classical diarrhea disease model is converted into the diffusive diarrhea epidemic model by including the diffusion terms in every compartment of the system. Basic assumptions of the proposed model are described for a vivid understanding of the model's behavior.

Benzimidazole chemistry in oncology: recent developments in synthesis, activity, and SAR analysis.

A six-membered benzene ring is fused with a five-membered imidazole ring at positions four and five, generating benzimidazole, the benzo derivative of imidazole and a bicyclic aromatic chemical compound. Benzimidazole is a significant pharmacophore in a variety of physiologically active heterocyclic compounds due to its distinctive characteristics and structural framework. Because benzimidazole is both aromatic and heterocyclic, it interacts with a range of biological targets metal ion interactions, π-π stacking, and hydrogen bonding.

Blockchain enabled privacy provisioning scheme for location based services in VANETs.

In recent years, vehicular ad hoc networks (VANETs) have emerged as a crucial component of intelligent traffic systems, offering enhanced road safety through autonomous, distributed, and dynamically structured communication. However, ensuring secure and privacy-preserving message broadcasting in VANETs remains a significant challenge due to their open-access nature. Existing solutions have addressed various security and privacy concerns, yet critical issues such as resistance to traffic analysis, unlinkability of messages, computational efficiency, and location privacy remain underexplored.

Synthesis, Molecular Characterization, and Antimicrobial Evaluation of Hydrazones Derived from 2-Hydrazinobenzimidazole.

Introduction: Hydrazones, due to the structural diversity of their nitrogen atoms, possess both electrophilic and nucleophilic properties, enabling strong hydrogen bonding interactions with enzymes and receptors. This study aimed to synthesize novel hydrazone derivatives and evaluate their antimicrobial potential.

Methods: Hydrazones were synthesized via condensation of 2-hydrazinobenzimidazole with various aldehydes or ketones using citric acid as an eco-friendly catalyst.

A review of the developments in adsorbents for the efficient adsorption of ibuprofen from wastewater.

This paper critically evaluates the recent advancements in developing adsorbents to remove ibuprofen (IBU) from wastewater. Adsorbent characteristics, their performance in removing IBU from wastewater in batch and column studies, the adsorption kinetics, isotherms, thermodynamics, and mechanisms, adsorbent regeneration, continuous adsorption, and future challenges are included in this paper. Activated carbons, nanomaterials, metal-organic frameworks, biochar, and other adsorbents have been developed to remove IBU from wastewater.

A study on the role of moderate optical band gap energy in dielectric properties of NiFeO nanoparticles by Ce ion doping for electronic device applications: the effect of doping concentration.

This research work employs a sol-gel process to prepare NiCeFeO ( = 0.00, 0.05, and 0.

Exploring the Potential of Pyridine Carboxylic Acid Isomers to Discover New Enzyme Inhibitors.

Pyridine carboxylic acid isomers - picolinic acid, nicotinic acid, and isonicotinic acid - have historically resulted in a plethora of drugs against tuberculosis, cancer, diabetes, Alzheimer's, angina, dementia, depression, allergy, respiratory acidosis, psoriasis, acne, hypertension, hyperlipidemia, HIV/AIDS (specifically HIV-1), among others. Despite the large number of therapeutic agents derived from these isomers, the research involving these scaffolds is still exceptionally active. The current surge in enzyme inhibitory activities by the compounds derived from them has further created space for the discovery of new drug candidates.

Advancing wind energy potential estimation through multidistribution wind speed analysis in coastal Pakistan.

Wind energy is becoming one of the most important elements toward the advancement of sustainable energy systems globally. The assessment of wind energy potential is critical to the optimization of resource application and improvement of technologies. This study focuses on fitting fourteen probability density functions (PDFs) to hourly wind speed data collected from six coastal cities of Pakistan: Gwadar, Jiwani, Karachi, Keti Bandar, Ormara, and Pasni, for the year 2023, measured at 10 m and 50 m heights.

Personalized learning in hybrid education.

The process of teaching and learning during the pandemic has been evolving globally, with many institutions transforming their approaches to enhance the teaching and learning experience. Despite the presence of improved frameworks due to the varied learning capabilities of students, it remains quite challenging to analyse individual characteristic features. Consequently, this research provides clear insights into the integration of the Personalised Learning Approach (PLA) to foster effective interaction with students.

Comprehensive study of stochastic soliton solutions in nonlinear models with application to the Davey Stewartson equations.

This article investigates the stochastic Davey-Stewartson equations influenced by multiplicative noise within the framework of the Itô calculus. These equations are of significant importance because they extend the nonlinear Schrödinger equation into higher dimensions, serving as fundamental models for nonlinear phenomena in plasma physics, nonlinear optics, and hydrodynamics. This paper is motivated by the need to understand how random fluctuations affect soliton behavior in nonlinear systems.

A PSO weighted ensemble framework with SMOTE balancing for student dropout prediction in smart education systems.

Student dropout is a critical issue that affects not only educational institutions but also students' mental well-being, career prospects, and long-term quality of life. The ability to predict dropout rates accurately enables timely interventions that can support students' academic success and psychological resilience. However, the imbalanced nature of student dropout datasets often results in biased and less effective predictive models.

Bee products in the fight against Helicobacter pylori and molecular interactions.

Gastric or duodenal ulcers can lead to upper gastrointestinal (GI) bleeding. Infection with Helicobacter pylori (H. pylori) is one of the most common infections in the world and can cause both gastric ulcers and gastric cancer.

Fabrication of gold/polyaniline/copper oxide electrode for efficient photoelectrochemical hydrogen evolution.

This study explores a novel photoelectrode composed of copper oxide (CuO), polyaniline (PANI), and gold (Au) for efficient hydrogen production through photoelectrochemical (PEC) water splitting. Structural and morphological analyses using various techniques confirm the successful fabrication of the ternary Au/PANI/CuO photoelectrode. The integration of Au, PANI, and CuO nanomaterials enhances light harvesting, facilitates charge transfer, and reduces charge recombination due to the plasmonic effect of Au and the synergistic interaction between PANI and CuO.

Solutions behavior of mechanical oscillator equations with impulsive effects under Power Caputo fractional operator and its symmetric cases.

This study investigates the qualitative behavior of mechanical oscillator equations with impulsive effects using the generalized Power Caputo fractional operator, encompassing several known derivatives (such as Caputo-Fabrizio and Atangana-Baleanu) as special cases. The operator's parameter 'p' offers enhanced flexibility in modeling memory effects. Key findings, derived through integral equation formulations and fixed-point theory (including Banach's contraction principle), establish rigorous conditions for the existence, uniqueness, and Ulam-Hyers stability of solutions under specific assumptions on the nonlinear and impulsive terms.

Analytical solutions of the time-fractional symmetric regularized long wave equation using the [Formula: see text] model expansion method.

In this paper, we introduce a new analytical technique to study the time-fractional symmetric regularized long wave (SRLW) equation, which is an important model for nonlinear wave phenomena in dispersive media. Combining the new [Formula: see text] model expansion technique with a conformable fractional derivative provides a systematic means of finding a wide class of exact traveling wave solutions, such as bright solitons, kink solitons, singular periodic solitons, and periodic solitons. which are crucial in optical and fluid systems, and their localized singularities, indicating wave-breaking or energy concentration effects, and their real-world implications.

Understanding the association of cell-surface proteins (ACE2 and GRP78) facilitating pathogen recognition: a computational approach.

Angiotensin-converting enzyme 2 (ACE2) has been reported to be the primary host cell receptor for recognizing SARS-CoV and SARS-CoV-2 spike proteins. This host-cell element, despite having a crucial role in normal cells, may be hijacked by viruses to invade human cells. It has been reported that ACE2 trafficking to the cell membrane is mediated by other cellular factors, such as the endoplasmic reticulum resident chaperone, named glucose-regulated protein 78 (GRP78).

Comprehensive study of optical, photocatalytic and dielectric properties of CdMnZnO annealed nanocomposites.

The structural, optical, photocatalytic and dielectric properties of CdMnZnO annealed nanocomposites prepared by Hydrothermal and subsequently annealed at temperatures between 200 °C and 600 °C. The particle size, crystallite size, and inter-plane separation were all enlarged with increased T at 600 °C and electrical dielectric loss increased. The specific surface area and photocatalytic activity were maximized, obtaining in this case a rate of degradation of 2 × 10s at 400 °C.

Magnesium Molybdate: An Efficient Nanosorbent for Methylene Blue Cationic Dye Removal from Aqueous Solutions.

The removal of methylene blue (MB) cationic dye from aqueous solutions was investigated by applying magnesium molybdate (β-MgMoO) as a nanosorbent. The β-MgMoO was synthesized through a simple, rapid, and efficient method. The MB dye removal process was optimized by evaluating various parameters such as temperature, contact time, nanosorbent dosage, pH, and initial cationic dye concentration.

Design and experimental validation of a compact dual band double negative metamaterial for energy harvesting applications.

This work presents a compact double-negative (DNG) metamaterial (MM) design optimized for energy harvesting (EH) applications. Current EH designs often face challenges such as large physical size, narrow operational bandwidth, and low efficiency. To overcome these limitations, we propose a novel MM structure composed of two concentric circular and two concentric rectangular resonators, each featuring 45-degree inclined gaps to enhance electromagnetic coupling and interaction.