Chemically-Fueled Time-Gated Luminescent Metamorphosis.

Recent quest for emulating lifelike smart materials for developing functional outcomes has been spurred by the unparalleled spatiotemporal control of natural systems. However, it is still highly challenging to replicate the progressive time-dependent programmable features of biological systems, such as adaptive broad-spectrum luminescence accompanying functions. Here in, a chemically-fueled transient hydrogel is created based on an aggregation-induced emission-active peptide conjugate (NI-VD).

Layered VSe as an Al-Ion Storage Cathode for Aqueous Aluminum-Ion Batteries with Fast Diffusion and Stability and Its Charge Storage Mechanism.

Aluminum (Al)-ion batteries have gained popularity because of their improved energy density, increased safety, eco-friendliness, abundant Al resources, and extremely attractive three-electron redox, making Al-ion batteries an appealing candidate. However, the progress in Al-ion batteries has been hindered by the unavailability of potential cathode materials that could reversibly host Al ions. In this work, we investigated VSe, a 2D material with a graphene-like layered structure, as a potential cathode for aqueous aluminum-ion batteries.

A 3D-printed cassette coupled with a paper-based aptasensor for advanced diagnosis of chikungunya virus towards commercialization.

Electrochemical sensors have attracted significant attention because of their vital role in the early identification of infectious diseases, indicating their usefulness in various diagnostic applications. Here, the present study reports the development of paper-based electrochemical aptasensors integrated into a 3D printed cassette for chikungunya virus detection at the point of care. The sensor is functionalised with a highly specific aptamer and employs silver nanoparticles to enhance electrochemical sensitivity.

Ultrasonic and microwave irradiation-aided leaching for effective desulphurization of high sulphur North-East Indian coal.

This present investigation focuses on desulphurization of high sulphur North-East Indian coal under ultrasonic and microwave irradiation-aided chemical leaching. The powdered coal was treated under four different conditions, such as alkali leaching under low-energy ultrasound energy (US), acid leaching under ultra-high frequency microwave energy (MW), ultrasonic followed by microwave treatment (US-MW) and microwave followed by ultrasonic treatment (MW-US). The ultrasonic treatment was conducted using 0.

Ion-partitioning effect promotes the electroosmotic mixing of non-Newtonian fluids in soft-patterned microchannels.

We numerically investigate the mixing characteristics of non-Newtonian fluids under the ion-partitioning effect in a micromixer having a built-in patterned soft polyelectrolyte layer (PEL) on its inner wall surfaces. We show that the mixing phenomenon is greatly modulated by the migration of counter-ions triggered by the Born energy difference caused by the electrical permittivity differences between the PEL and bulk electrolyte. We demonstrate counter-ion concentration field, flow velocity variation, species concentration distribution, mixing efficiency and neutral species dispersion by varying the electrical permittivity ratio and rheological parameters.

Iridium catalyzed intramolecular cyclization of allyl alcohol-indole hybrids: rapid access to photoluminescent 5-benzo[]carbazoles.

Herein, we report an intramolecular cyclization of secondary allylic alcohol-tethered indoles using iridium catalysis in the presence of diphenyl phosphate. This first-of-its-kind allylic substitution-aromatization cascade efficiently delivers 6-ethyl-5-benzo[]carbazoles in excellent yields (up to 96%) under mild conditions. The scope was extended to a naphthalen-1-ylmethanol containing 1-benzo[]indole derivative.

Beyond drive cycles: mapping the intricacies of electric vehicle battery health in diverse environments and driving conditions.

As electric two-wheelers become increasingly prevalent in emerging markets, understanding the real-world degradation of their batteries is crucial for ensuring reliability, longevity, and cost-effectiveness. Traditional battery aging studies are heavily based on standard drive cycles that do not capture the variability introduced by diverse user behaviors, regional conditions, and charging habits. This study proposes a comprehensive and adaptable framework for evaluating the end-of-life (EOL) of EV batteries in realistic usage scenarios.

An EJC-independent novel isoform of MAGOH: the MAGOH-Δ37 isoform and its interactome capture.

The Exon-Junction Complex (EJC) is essential for post-transcriptional gene regulation, with MAGOH as one of its core components, known for its involvement in mRNA surveillance and translation. In this study, we characterize an evolutionarily conserved, alternatively spliced isoform of MAGOH, i.e.

Organocatalytic Regio- and Enantioselective Friedel-Crafts Alkylation of N-Aryl Anilines with Aurone-Derived Azadienes: Access to Benzofuran Embedded Triarylmethanes.

Herein, we disclose a catalytic asymmetric Friedel-Crafts alkylation of N-aryl anilines with aurone-derived azadienes for the first synthesis of benzofuran and N-aryl aniline containing triarylmethanes. An easily available chiral phosphoric acid, TRIP, was found to be effective for this reaction. The triarylmethanes with benzofuran and N-aryl aniline motifs were obtained in moderate yields with high regio- and good to high enantioselectivities.

Extracellular Vesicles in Osteogenesis: A Comprehensive Review of Mechanisms and Therapeutic Potential for Bone Regeneration.

Extracellular vesicles (EVs) are nanoscale, membrane-bound particles secreted by diverse cell types and act as pivotal mediators of intercellular communication during bone regeneration. These vesicles transport bioactive cargo including proteins, lipids, mRNAs, and microRNAs that modulate osteogenesis, angiogenesis, and immune responses within the bone microenvironment. EVs originating from mesenchymal stem cells, osteoblasts, endothelial cells, and macrophages have demonstrated substantial potential to promote bone formation, inhibit bone resorption, and enhance vascularization.

-annulated unsymmetrical perylene ester imide exhibiting room-temperature columnar hexagonal mesophases.

Incorporating heteroatoms into π-conjugated aromatic cores enables the formation of robust self-assembled architectures by leveraging enhanced intermolecular interactions, including dipole-dipole, van der Waals, and σ-hole mediated non-covalent interactions. These improved self-assemblies are key for achieving superior performance in organic semiconductors. Herein, we present the rational design and synthesis of a selenium-annulated unsymmetrical perylene diester imide (PEI-SeST), wherein a swallow-tail moiety at the imide position, in concert with decyl substituents at the ester functionalities, stabilizes an enantiotropic columnar hexagonal liquid crystalline phase at ambient temperature, which is in contrast to the perylene ester imide derivative without a heteroatom.

Label-Free HPLC Method to Evaluate Neuraminidase Activity in Biological Fluids Containing the Newcastle Disease Virus.

Newcastle disease virus utilizes its multifunction hemagglutinin neuraminidase (HN) protein for sialic acid recognition and its cleavage from the adjacent lactose unit. Detection of neuraminidase activity of HN is crucial for studying NDV infection biology. Traditional neuraminidase assays predominantly employ synthetic fluorogenic substrates such as 2'-(4-methylumbelliferyl)-α-D-N-acetylneuraminic acid.

Reusable Brønsted Acidic Ionic Liquid Catalyzed Reductive Alkylation of Quinolines to Functionalized Tetrahydroquinolines.

A Brønsted acidic ionic liquid (BAIL)-catalyzed one-pot tandem reduction of quinoline to tetrahydroquinoline (THQ) followed by reductive alkylation by the aldehyde has been demonstrated under mild reaction conditions with a shorter reaction time. This step-economical synthetic approach is suitable for late-stage functionalization of complex bioactive molecules. The reaction is highly chemoselective and tolerates a wide range of reducible-sensitive functional groups.

Transformable/modifiable directing group-assisted C(sp)-H functionalizations.

Directing groups have been widely used for transition metal-catalyzed regioselective C-H functionalizations. The heteroatoms in the directing group coordinate with the metal catalyst and activate relatively inert C-H bonds. However, after the desired C-H functionalization, the directing groups may not always be necessary, so their removal demands extra synthetic steps.

Common Nefafu ( L.)-Mediated Silver Nanoparticles for Physicochemical Insights into the Protein Corona Formation and Inhibition of Fibrillation of Human Serum Albumin.

Engineering nanomaterials with products isolated from natural resources is attractive for targeted therapeutic applications. Prior to the biomedicinal applications, one significant facet of nanoparticles is the understanding of protein corona formation and its relative binding aspects. In this perspective, we have synthesized two different silver nanoparticles, one with the extract of the leaves of a traditional herb , commonly known as "Nefafu", and the other with one of its major polyphenolic compounds, apigenin, and their complexations were studied with the model protein human serum albumin (HSA).

Unlocking therapeutic potential: Exploring nuclear receptors in brain cancer treatment.

Brain cancer remains among the most lethal malignancies worldwide, with approximately 321,476 new cases and 248,305 deaths reported globally in 2022. The treatment of malignant brain tumors presents substantial clinical challenges, primarily due to their resistance to standard therapeutic approaches. Despite decades of intensive research, effective treatment strategies for brain cancer are still lacking.

Artemisinin toxicity in HepG2 liver carcinoma cells is linked to protein network in host and molecular interactions with cellular drug targets.

Artemisinin treatment at high concentration or prolonged period is exhibiting severe toxicity in liver, kidney and cardio toxicity. Artemisinin is killing HepG2 liver carcinoma cells with an IC of 17.33 ± 2.

Wavelet scattering transformation for sub-surface damage detection and localization in PZT sensor.

Structural Health Monitoring (SHM) systems typically employ piezoelectric sensors for the monitoring of variations in structural members. However, subsurface deterioration or damage within the sensors can impair the system's overall reliability and precision. This drawback can be addressed using a suggested reference-free detection method and subsurface defect localization for Lead zirconate titanate (PZT) sensor defects, combining signal processing and machine-learning-based feature extraction techniques.

Interface-driven Pd-Ag-Cu/C nanocomposites with increased oxygen reduction reaction kinetics.

Highly dispersed PdAgCu/C nanocomposites with enhanced catalytic activity and stability were synthesized a solvothermal method. Structural characterization confirms the formation of a multimetallic nanocomposite consisting of well-distributed Pd, Ag and Cu domains on the carbon support. The close proximity of these metal domains facilitates interface-driven electronic modulation, which contributes to improved oxygen reduction reaction (ORR) kinetics.

Sustainable water treatment: leveraging drinking water treatment sludge for enhanced water quality.

This study presents a novel and sustainable approach to enhance drinking water treatment by transforming Drinking Water Treatment Sludge (DWTS), a challenging waste byproduct, into a valuable resource. We investigated the combined coagulation-adsorption process, utilising DWTS as an adsorbent alongside alum coagulant, to address the persistent issue of dissolved natural organic matter (NOM) and turbidity removal. Our findings demonstrate that adding DWTS at a dose of 1.

Sulfonate Derivative of HOAt (CTSOAt) as a Coupling Reagent for the Construction of C-N, C-O, and C-C Bonds.

We have developed a novel recyclable coupling reagent, 3-[1,2,3]triazolo[4,5-]pyridin-3-yl 5-chlorothiophene-2-sulfonate (CTSOAt), in a faster and straightforward way. The reagent activates carboxylic acids by forming acyl-OAt intermediates, facilitating the synthesis of amides, esters, and peptides with good yields and excellent chirality retention. The reagent also offers the formation of ketones from carboxylic acids through Pd-catalyzed cross-coupling reactions.

Free-roaming dog populations and movement methodologies for global rabies elimination: knowns and unknowns - a scoping review.

Understanding free-roaming dog (FRD) demographics and movement patterns is essential for effective rabies control interventions, such as mass dog vaccinations (MDV). This review assesses published studies on FRD movement and enumeration to assess existing knowledge. A scoping review was conducted following PRISMA guidelines.

Conformation-Induced Excimer Formation in Covalently Linked Dimer of Azulene-Fused Anthracene.

Excimers are important excited-state homodimeric complexes affecting excited-state processes such as symmetry-breaking charge separation (SB-CS) and singlet fission (SF). Their formation is influenced by factors such as the solvent environment, spatial orientation, and distance between the chromophores. Our study uses MP2 and ADC(2) methods to explore excimer formation in a specific conformer of covalently linked azulene-fused anthracenes, out of two conformers, and .

The ClpA chaperone and the two adaptor proteins modulate the fate of the model substrate tagged with a SsrA-degron of Leptospira.

Bacterial caseinolytic protease (Clp) chaperone-protease complexes are essential for the degradation of misfolded and aggregated protein substrates. The spirochaete Leptospira interrogans possesses a set of Clp adaptor proteins (ClpS1 and ClpS2) and chaperones (ClpX, ClpA and ClpC), which are believed to associate with two distinct isoforms of ClpP (ClpP1 and ClpP2). This study explores the structural and functional properties of LinClpA, LinClpS1 and LinClpS2 derived from L.

A Primer on Monkeypox Infection: An Emerging Threat to Global Public Health.

Monkeypox (mpox) is caused by a poxvirus closely related to the smallpox virus. It spreads by intimate contact between humans and animals. Prior immunization against smallpox only provides partial protection against mpox.