Consortium profile: the methylation, imaging and NeuroDevelopment (MIND) consortium.

Epigenetic processes, such as DNA methylation, show potential as biological markers and mechanisms underlying gene-environment interplay in the prediction of mental health and other brain-based phenotypes. However, little is known about how peripheral epigenetic patterns relate to individual differences in the brain itself. An increasingly popular approach to address this is by combining epigenetic and neuroimaging data; yet, research in this area is almost entirely comprised of cross-sectional studies in adults.

Distinct clinical outcomes according to molecular subgroups in relapsed endometrial carcinoma: A cohort study.

Objective: This study evaluated time to progression and post-recurrence disease-specific survival in molecularly classified endometrial carcinoma to improve understanding of disease biology and factors influencing tumor aggressiveness.

Methods: In this retrospective cohort study, immunohistochemistry and polymerase-ϵ (POLE) sequencing were used for molecular classification and determination of estrogen receptor and programmed death-ligand 1 (PD-L1) expression.

Results: We identified 1146 patients with molecularly classified endometrial carcinoma, of whom 220 (19.

European survey on metabolic and cardiovascular risk in Cushing syndrome.

Background: Cushing's syndrome (CS) is associated with increased metabolic and cardiovascular (CV) risk factors and morbidities. Evidence-based guidelines for the management of these issues in active or remitted CS are not available, so best practice is derived from guidelines developed for the general population. We aimed to evaluate the awareness and practice variation for CV comorbidities of CS across Reference Centres (RCs) of the European Reference Network on Rare Endocrine Conditions (Endo-ERN).

Nonoperative treatment versus volar locking plating for distal radius fracture in patients aged 65 years or older (DRIFT trial): A randomized controlled trial.

Background: The optimal management of distal radius fractures (DRFs) in older patients remains debatable. A knowledge gap exists concerning how to manage fractures with early malalignment during nonoperative treatment. We conducted a prospective, multicenter, and randomized controlled trial to compare nonoperative treatment to operative treatment with volar locking plating (VLP) in the management of primarily malaligned DRFs and DRFs that exhibit early malalignment during nonoperative treatment.

Three-Dimensional Presentation of Tongue Squamous Cell Carcinoma Histopathology and Magnetic Resonance Imaging-A Novel Image Fusion Method.

Background: Three-dimensional (3D) modeling has been used in the management of bony head and neck tumors, but not in soft tissue tumors. Currently, histopathological findings of oral squamous cell carcinomas (OSCC) are presented as two-dimensional images. Previously, we developed a 3D image fusion method that presents tumor histopathology and MRI in 3D form.

Neurocognitive and emotional benefits of choir singing and their mediating factors across adulthood.

Background: Our understanding on how cognitive and socioemotional well-being factors interact throughout adulthood has increased remarkably over the past decades, encouraging the use of cognitively engaging leisure activities, such as music, to promote healthy ageing. Choir singing has attracted particular interest in this regard with its established benefits on socioemotional well-being. Outside the clinical context, however, the cognitive and well-being effects induced by musical activities are often studied separately, leaving it unclear to what extent they interact in contributing to healthy ageing.

Implant treatment modalities of non-syndromic congenitally missing premolars: a retrospective case series of 74 specialist care patients over an 11-year-cohort.

Objective: The study aims to evaluate the course of implant treatment for congenitally missing lower -second premolars in patients referred to publicly funded specialist care over an 11-year period.

Material And Methods: This retrospective, register-based cohort study selected patient data on dental implant treatment in the lower second premolar region from 2009 to 2019 (n = 146). After applying exclusion criteria, the final sample included 74 patients.

Effects of Whole-Body Cryotherapy Combined With Conventional Obesity Management Versus Obesity Management Alone: A Clinical Trial.

Objective: To investigate whether whole-body cryotherapy (WBC) enhances weight loss, brown adipose tissue (BAT) activation, and metabolic outcomes during obesity management.

Methods: Nineteen adults with obesity were assigned to a 12-month lifestyle-based obesity management intervention with 28 WBC sessions (-110°C, 3-4 min, ~2 × week) over the first 5 months (CRYO, n = 10) or the intervention without WBC (CON, n = 9). The primary outcome was weight loss (5 and 12 months).

Comparison of observed image quality and technical image quality parameters in 3D-FLAIR images.

Objectives: Magnetic resonance imaging (MRI) is a complex medical imaging method where multiple technical and physiological factors may lead to undesired changes in image quality. The quality control methods utilizing test objects are useful in measuring technical performance, but they may not fully detect all factors present in clinical imaging. In this study, we developed methodologies to quantify observer-based image quality and to compare these observations with technical quality control (QC) parameters.

The Prevalence of Myopia in Finnish Conscripts Has not Increased in Recent Decades and Is Lower Than in Many East and Southeast Asian Countries.

Purpose: This study aimed to determine the prevalence of myopia among Finnish conscripts and to identify the factors associated with its occurrence in Finland.

Methods: A total of 1694 conscripts (mean age: 19.3 ± 1.

Development of a core patient-centred outcome set for adults living with obesity: a modified delphi-based international consensus.

Background: Obesity is a chronic disease linked to over 200 health conditions, reduced quality of life, and increased mortality. Despite the availability of multimodal treatments, there is a lack of standardised, patient-centred outcome measures to effectively assess and improve clinical care. This project aimed to define a core set of standardised outcome measures for adults with obesity, incorporating both patient-reported and clinician-reported outcomes.

Orthosis Followed by Trapeziectomy for Thumb Base Osteoarthritis: A Cohort Pilot Study on Pain and Function.

Purpose: This study aimed to assess how much symptoms resolve during a 6-week continued nonsurgical treatment with an orthosis and after trapeziectomy in people with thumb carpometacarpal joint osteoarthritis (CMC-1 OA) referred for surgical consultation. The data on symptom resolution magnitude and trajectory can help inform patients about postsurgical recovery and assist researchers in designing clinical trials to evaluate surgery's effectiveness for CMC-1 OA.

Methods: We recruited 52 patients with CMC-1 OA referred for surgical consultation.

Acylcarnitine enrichment as a characteristic of rheumatoid arthritis fibroblast-like synoviocyte metabolic fingerprint.

Objective: In rheumatoid arthritis (RA), fibroblast-like synoviocytes (FLS) alter their metabolism to support their activation. We aimed to analyse the full spectrum of metabolic alterations associated with RA by performing untargeted metabolomics in RA FLS vs. non-inflamed (NI) FLS.

Mortality After Cerebral Venous Thrombosis.

Objectives: Cerebral venous thrombosis (CVT) has historically had a poor prognosis, but advances in diagnosis and treatment may have improved outcomes. This study evaluated mortality rates, causes of death, and predictors of early and late mortality in CVT using international data.

Methods: In this multicenter cohort study, we analyzed data from adults with CVT enrolled between 1995 and 2021.

Antibiotic-resistant Acinetobacter baumannii can be killed by a combination of bacteriophages and complement.

Infections caused by multidrug-resistant Acinetobacter baumannii are an emerging global health threat. Although phages have shown promising results in treating bacterial infections, the mechanisms of the combined effect of phages and innate immunity on clearing A. baumannii remain unclear.

Environmental exposure-related health worries, work ability and health, surveyed by occupational health services.

Objectives: Environmental intolerance (EI) can negatively impact well-being and daily life, and even lead to disability. Healthcare can detect EI early and conduct interventions. This study explored ways of identifying environmental exposure-related health worries and EI during occupational health (OH) check-ups, and their associations with unselected working-age employees' perceived work ability, stress and overall health.