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http://dx.doi.org/10.1016/j.jtct.2025.08.023 | DOI Listing |
Transplant Cell Ther
September 2025
Finnish Red Cross Blood Service, Helsinki, Finland. Electronic address:
Eur J Haematol
July 2024
Anthony Nolan Research Institute, Royal Free Hospital, London, UK.
Objectives: NKG2D is an activating receptor expressed by natural killer (NK) and CD8+ T cells and activation intensity varies by NKG2D expression level or nature of its ligand. An NKG2D gene polymorphism determines high (HNK1) or low (LNK1) expression. MICA is the most polymorphic NKG2D ligand and stronger effector cell activation associates with methionine rather than valine at residue 129.
View Article and Find Full Text PDFHum Immunol
May 2020
Department of Gynecology and Obstetrics, Infectious Diseases in Gynecology and Obstetrics Sector, Post Graduate Program of Gynecology and Obstetrics, Clinics Hospital of Federal University of Paraná (UFPR), Rua General Carneiro, 181, Alto da Glória, CEP 80060-900 Curitiba, Paraná, Brazil; Genetic
Cervical carcinoma and cervical intraepithelial neoplasia (CIN) are associated with persistent infection by oncogenic subtypes of HPV (Human Papillomavirus). Factors linked to immunity, genetics and others like oral contraceptive use, sexual behavior, coinfections with other microorganisms and smoking seem to influence the mechanisms that determine regression or progression to CIN and cervical cancer. We investigated the effect of the MHC class I chain-related gene A (MICA) and Killer Cell Lectin Like receptor K1 (KLRK1) genes on cervical cancer and CIN lesions susceptibility in a group of 195 patients from southern Brazil.
View Article and Find Full Text PDFInt J Immunogenet
October 2020
INSERM U955, Translational Psychiatry, Creteil, France.
Identification of candidate genes associated with susceptibility of breast cancer can have a significant impact at a cancer management national healthcare systems level, making genetic testing more affordable and cost-effective. We have previously shown that the major histocompatibility complex class I-related chain A (MICA) was related to breast cancer and plays an important role in modulating immune response mechanisms through NKG2D receptor activation. Compared to our previous study, in this work, we recruited a new cohort composed of 354 unrelated Tunisian women affected by breast cancer and 380 age-matched women as controls, all genotyped for MICA-129 Met/Val (rs 1051792).
View Article and Find Full Text PDFFront Immunol
February 2017
All India Institute of Medical Sciences, New Delhi, Delhi , India.
An ever growing number of reports on graft rejection and/or failure even with good HLA matches have highlighted an important role of non-HLA antigens in influencing allograft immunity. The list of non-HLA antigens that have been implicated in graft rejection in different types of organ transplantation has already grown long. Of these, the Major Histocompatibility Complex class I chain-related molecule A (MICA) is one of the most polymorphic and extensively studied non-HLA antigenic targets especially in the kidney transplantation.
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