Trajectory and risk factors of cognitive level in ICU delirium patients after transfer out of the ICU: a protocol for a prospective cohort study.

Introduction: Delirium is a prevalent neuropsychiatric disorder in the intensive care unit (ICU), associated with poorer health outcomes, including extended duration of mechanical ventilation, prolonged ICU stays, and persistent or long-term cognitive impairment. Substantial evidence has indicated that the frequency, duration and severity of delirium during hospitalisation are significant risk factors for cognitive dysfunction in patients after ICU discharge. While existing studies have investigated the association between ICU delirium and subsequent cognitive outcomes, their analytical approaches have predominantly employed conventional longitudinal methods.

Safety evaluation of tucatinib: Adverse event signal mining and analysis based on the FAERS database.

The purpose of this study was to evaluate the adverse events (AEs) associated with tucatinib by mining data from the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS) and explore potential drug-related AEs, thereby guiding safe clinical use.

Transcutaneous electrical acupoint stimulation alleviates insomnia, negative emotions, and neurotransmitter imbalance in methamphetamine withdrawal: A randomized controlled trial.

Background: This randomized controlled trial investigated the therapeutic effects of transcutaneous electrical acupoint stimulation (TEAS) on insomnia, negative emotions, and neurotransmitter levels in patients undergoing methamphetamine (METH) withdrawal.

Methods: We enrolled 84 eligible patients from the Kangxin Hospital of Guizhou Province, China (August 2023-December 2024), randomly allocating them to TEAS (n = 42) or sham-TEAS (n = 42) groups. The patients were divided into a TEAS group of 42 cases and a sham-TEAS group of 42 cases according to the randomized, single-blind and control principle.

The effects of tolerogenic dendritic cells on the TLR4/MyD88/NF-κB signaling pathway in rats with collagen-induced arthritis.

Objective: Rheumatoid arthritis (RA) is a common inflammatory autoimmune disease. Previous studies have emphasized tolerogenic dendritic cells(tolDCs) could attenuate inflammatory lesions by inducing specific immune tolerance in RA animal models, but the mechanism still needs further investigation. This study focused on revealing the effects of tolDCs on the TLR4/MyD88/NF-κB signaling pathway that mediates inflammation.

Impact of dual sensory impairment on cognition in older Chinese adults: a moderated chain-mediated effect.

Objective: Although sensory impairment has been identified as a risk factor for cognitive decline, little is known about the underlying mechanisms that connect dual sensory impairment to cognitive ability. This research used a moderated chain-mediated model to investigate the underlying mechanisms behind the association between dual sensory impairment and cognitive ability.

Methods: People aged 60 years and older from seven medical institutions, three communities, and five nursing homes in Zunyi city, Guizhou Province, were selected for the study from October 2022 to September 2023 via convenience sampling.

Prognostic Role of SETDB2 in Clear Cell Renal Cell Carcinoma: Linking Immune Infiltration, Cuproptosis, and Tumor Suppression.

Background: Clear cell renal cell carcinoma (ccRCC) is a relatively frequently diagnosed form of urological cancer that is highly malignant and associated with high rates of patient mortality. At present, there are few effective options for treating advanced cases of ccRCC, emphasizing the need to establish novel biomarkers and targets suitable for therapeutic intervention. SET domain bifurcated histone lysine methyltransferase 2 (SETDB2) belongs to the Su(var)3-9 subfamily of methyltransferases and has been linked to various forms of cancer, but the role it plays in ccRCC remains to be fully established.

Targeted activation of ErbB4 receptor ameliorates neuronal deficits and neuroinflammation in a food-borne polystyrene microplastic exposed mouse model.

The impact of polystyrene microplastics (PS-MPs) on the nervous system has been documented in the literature. Numerous studies have demonstrated that the activation of the epidermal growth factor receptor 4 (ErbB4) is crucial in neuronal injury and regeneration processes. This study investigated the role of targeted activation of ErbB4 receptor through a small molecule agonist, 4-bromo-1-hydroxy-2-naphthoic acid (C11H7BrO3, E4A), in mitigating PS-MPs-induced neuronal injury.

A Latent Class Analysis of Resilience and Its Relationship With Care Burden and Psychological Distress in Family Caregivers of Older Adults With Disability.

Given the challenging circumstances of aging with disability, family caregivers (FGs) face significant strain. Resilience, however, is a crucial protective factor against adverse caregiving outcomes. The study thus aimed to determine the latent classes of resilience among FGs and examine how these classes are related to care burden and psychological distress.

Social dilemma for 30 years: Progress, framework, and future based on CiteSpace analysis.

Social dilemmas have been a popular research topic in the past 30 years, yet there is still a lack of interdisciplinary reviews. This study represents the first attempt to conduct a bibliometric analysis of social dilemma research over the past 30 years, aiming to identify the research status, research hotspots, and future trends in this domain. We conduct an interdisciplinary analysis of 3630 articles from 1993 to 2023 using CiteSpace software.

Effects of exercise dose based on the ACSM recommendations on depression in hemodialysis patients: a systematic review and meta-analysis of randomized controlled trials.

Objective: To explore the impact of various exercise doses on depressive symptoms among hemodialysis patients and offer valuable guidance for the selection of optimal exercise doses in clinical practice settings.

Methods: A comprehensive systematic review was conducted across four major databases, namely, PubMed, Embase, Web of Science, and Cochrane Library, covering the period from their inception until August 2024. Exercise interventions were classified based on adherence to American College of Sports Medicine (ACSM) recommendations, dividing studies into groups with high and low/uncertain ACSM adherence.

Targeted ErbB4 receptor activation prevents D-galactose-induced neuronal senescence via inhibiting ferroptosis pathway.

Background: Neuronal senescence is a common pathological feature of various neurodegenerative diseases, with ferroptosis playing a significant role. This study aims to investigate the role of ErbB4 receptor activation in preventing D-Galactose (D-gal)-induced neuronal senescence.

Methods: Mice subjected to D-gal-induced aging were administered a small molecule ErbB4 receptor agonist (E4A), identified via virtual screening, melatonin, or a combination of both.

Identification and validation of the important role of KIF11 in the development and progression of endometrial cancer.

Background: Human kinesin family member 11 (KIF11) plays a vital role in regulating the cell cycle and is implicated in the tumorigenesis and progression of various cancers, but its role in endometrial cancer (EC) is still unclear. Our current research explored the prognostic value, biological function and targeting strategy of KIF11 in EC through approaches including bioinformatics, machine learning and experimental studies.

Methods: The GSE17025 dataset from the GEO database was analyzed via the limma package to identify differentially expressed genes (DEGs) in EC.

Sustainable rural development: differentiated paths to achieve rural revitalization with case of Western China.

Rural Revitalization (RR) is a key national strategy in China aimed at sustainable rural development and has gained significant attention. Given the unique characteristics of different villages, understanding differentiated paths to achieve RR is essential. This study introduces a new "5I Framework" (INDUS-INHAB-INDOC-INFRA-INCOM) to assess RR's overall development status (ODS) and differentiated paths.

SOX13 as a potential prognostic biomarker linked to immune infiltration and ferroptosis inhibits the proliferation, migration, and metastasis of thyroid cancer cells.

Background: SOX13 is a transcription factor belonging to the SOX family. SOX proteins are critical regulators of multiple cancer progression, and some are known to control carcinogenesis. Nevertheless, the functional and clinical significance of SOX13 in human thyroid cancer (THCA) remain largely unelucidated.

Evolving Trends in College Students' Health Education: A Bibliometric Analysis.

This study offers new insights into college students' health education (CSHE) regarding its research status, hot spots, and trends by conducting a comprehensive bibliometric analysis of this field in the past decade (2014 to 2024). Specifically, we analyzed publication trends and used the bibliometric method with CiteSpace software to explore collaborative networks, detailed co-citation status, and co-occurrence dynamics based on 1358 Web of Science Core Collection articles. Our results indicate increased relevant publications and the collaboration networks show complex institutional and regional partnerships.

The relationship between multimorbidity and cognitive function in older Chinese adults: based on propensity score matching.

Objective: The goal of this study was to further validate the effect of multimorbidity on cognitive performance in older adults after controlling for confounders using propensity score matching (PSM).

Methods: A cross-sectional survey of older adult people aged 60 years or older selected by convenience sampling was conducted in seven medical institutions, three communities, and five nursing homes in Zunyi City, Guizhou Province. The data collected included general information, health-related information, and Mini-Mental State Examination (MMSE) scores.

as a potential prognostic biomarker in hepatocellular carcinoma linked to immune infiltration and ferroptosis.

Objective: is expressed in numerous malignancies, including hepatocellular carcinomas (HCC), but its oncogenic function has not been elucidated. Here, we performed a comprehensive bioinformatics analysis of the Liver Hepatocellular Carcinoma (LIHC) dataset to investigate the function of in tumorgenesis.

Methods: expression data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) were validated by immunohistochemistry (IHC).

Frontline Nurses' Job Satisfaction and Missed Nursing Care in a COVID-19 Dedicated Hospital in China: A Cross-Sectional Study.

This study examined the current situation and relationship between missed nursing care (MNC) and job satisfaction among frontline nurses in a hospital dedicated to treating COVID-19 patients in China. Many dedicated hospitals were constructed or refurbished to centrally manage patients with COVID-19. Most nurses and doctors in these hospitals were redeployed from other departments or hospitals.

Reducing polypyrimidine tract‑binding protein 1 fails to promote neuronal transdifferentiation on HT22 and mouse astrocyte cells under physiological conditions.

In contrast to prior findings that have illustrated the conversion of non-neuronal cells into functional neurons through the specific targeting of polypyrimidine tract-binding protein 1 (PTBP1), accumulated evidence suggests the impracticality of inducing neuronal transdifferentiation through suppressing PTBP1 expression in pathological circumstances. Therefore, the present study explored the effect of knocking down PTBP1 under physiological conditions on the transdifferentiation of mouse hippocampal neuron HT22 cells and mouse astrocyte (MA) cells. A total of 20 µM negative control small interfering (si)RNA and siRNA targeting PTBP1 were transfected into HT22 and MA cells using Lipo8000 for 3 and 5 days, respectively.

The interaction between instrumental activities of daily living and dual sensory function on cognition among the elderly in China: A cross-sectional survey.

To explore the interaction of instrumental activities of daily living (IADLs) and dual sensory function on cognition in the elderly. A cross-sectional survey was conducted in six general hospitals in China, from October 2022 to December 2022. Data collection included general information, IADLs scale, self-reported sensory function questionnaire, and mini-mental state examination (MMSE).

Caregiving burden and positive aspects of caregiving in schizophrenia: Mediating roles of hope and social support.

Caring for an ill relative with schizophrenia can lead to both negative and positive experiences. The study aimed to determine the relationship between caregiving burden and positive caregiving experiences and evaluate the roles of hope and social support as possible mediators in this relationship. This study included 344 Chinese family caregivers of adults with schizophrenia.