Early Diastolic Dysfunction Detection in Hypertension: CMR-Derived Left Atrial Strain.

Rationale And Objectives: This study aimed to investigate the role of cardiac magnetic resonance (CMR)-derived left atrial (LA) strain parameters in evaluating early cardiac dysfunction in hypertensive patients and to assess their diagnostic utility for left ventricular diastolic dysfunction (LVDD).

Methods: A total of 150 hypertensive patients and 60 healthy controls were retrospectively enrolled, with all participants undergoing both echocardiographic and CMR examinations. Hypertensive patients were stratified by LVDD severity based on current guidelines.

Construction and Validation of a Novel Prognostic Model Based on Cervical Cancer-Related Genes.

Background: Cervical cancer (CC) is the fourth most frequently diagnosed cancer and the fourth leading cause of cancer-related deaths in women worldwide, however, the treatment options for advanced CC are limited. Therefore, there is an urgent need in the clinic for reliable prognostic models to guide clinical decision-making.

Methods: We conducted differential gene expression analysis on cervical cancer samples and normal samples to obtain differentially expressed genes (DEGs).

Leveraging neuroinformatics to understand cognitive phenotypes in elite athletes through systems neuroscience.

Introduction: Understanding the cognitive phenotypes of elite athletes offers a unique perspective on the intricate interplay between neurological traits and high-performance behaviors. This study aligns with advancing neuroinformatics by proposing a novel framework designed to capture and analyze the multi-dimensional dependencies of cognitive phenotypes using systems neuroscience methodologies. Traditional approaches often face limitations in disentangling the latent factors influencing cognitive variability or in preserving interpretable data structures.

Effectiveness of an Enhanced Nursing Intervention Program Combining Infection Control and Respiratory Function Training in Patients With Leukemia and Respiratory Infections During Chemotherapy.

To evaluate the effectiveness of a comprehensive nursing intervention program combining enhanced infection control measures with structured respiratory function training for patients with leukemia and respiratory infections during chemotherapy. 400 adult patients with leukemia in our hospital from May 2023 to June 2024 were randomly assigned to an intervention group or a control group. The intervention group received an enhanced nursing care program, while the control group received standard care.

Paediatric-inspired regimen reduces central nervous system relapse in adult acute lymphoblastic leukaemia.

Central nervous system (CNS) is the common site of extramedullary relapse in adult acute lymphoblastic leukaemia (ALL) and the outcome of CNS relapse patients remains poor. This study aimed to investigate whether a paediatric-inspired chemotherapy regimen can reduce CNS relapse in adult ALL compared to the adult regimen. A total of 1005 newly diagnosed adult patients with ALL were enrolled in this study, including 596 patients who received the Hyper-CVAD (cyclophosphamide, vincristine, doxorubicin[adriamycin], and dexamethason) adult regimen and 409 patients who treated with the Precision Classification-Directed Target Total Therapy-ALL-2016 (PDT-ALL-2016) paediatric-inspired chemotherapy regimen.

The mechanisms and therapeutic role of nuclear factor, erythroid derived 2,-like 1 in cancers.

Nuclear factor, erythroid derived 2,-like 1 (NFE2L1), a member of the CNC-bZIP transcription factor family, is a key regulator of cellular homeostasis by influencing oxidative stress, proteasome activity, and other factors. NFE2L1 plays a dual role in tumor development and progression; the molecular mechanisms underlying these processes are partially understood and are closely associated with oxidative stress, proteasome activity, and metabolic pathways. Furthermore, NFE2L1 also plays a role in cancer therapy by primarily regulating antioxidant effects and proteasome activity.

Harnessing dual-channel probiotics to synergistically correct intestinal and vaginal dysbiosis after antibiotic disruption.

Antibiotics are widely used to treat infectious diseases, yet antibiotic therapy has been shown to disrupt symbiotic microbiota. Notably, the dosage and duration of antibiotic use for specific infections may exert detrimental effects on microbiota in non-infected sites. Here, we propose a dual-channel probiotic delivery strategy to address gut and vaginal dysbiosis caused by antibiotic therapies.

Long-term survival of a SMARCA4-deficient undifferentiated thoracic tumor with brain metastasis successfully treated with multimodal treatment: a case report and literature review.

Background: SMARCA4-deficient undifferentiated thoracic tumor (SMARCA4-UT) is a rare and highly aggressive malignancy characterized by early distant metastasis and a poor prognosis, with a median overall survival (OS) of only 4-7 months. Traditional therapies offer limited benefit, while emerging data suggest the efficacy of combined immunotherapy, chemotherapy, and anti-angiogenic approaches. We report a case of a 52-year-old male with a heavy smoking history who presented with loss of consciousness and limb convulsions.

Next-generation immunotherapy in relapsed/refractory multiple myeloma: Strategies to achieve sustained MRD negativity.

This study critically examines the evolving landscape of Multiple Myeloma (MM) treatment, spotlighting the shift towards immunotherapeutic strategies in combating this complex hematological malignancy. Despite the clinical challenges posed by MM, including its high relapse and progression rates, recent therapeutic innovations have ushered in a new era of treatment possibilities. The advent of proteasome inhibitors and immunomodulatory drugs, and more recently BCMA‑targeted immunotherapies such as CAR‑T cells and bispecific antibodies, has broadened therapeutic options in multiple myeloma.

The natural compound stachyose targets SGLT2-mediated metabolic reprogramming to ameliorate diabetic kidney disease.

Background: Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease with no curative treatment currently available. Aberrant metabolic reprogramming in renal tubular epithelial cells contributes to renal fibrosis in DKD. Sodium-glucose cotransporter-2 (SGLT2) is upregulated in DKD and plays a central role in promoting metabolic dysfunction.

Tegoprazan-based versus esomeprazole-based triple therapy plus bismuth for first-line Helicobacter pylori eradication: A nationwide, multicenter, double-blind, double-dummy, randomized controlled trial.

Background: Although triple therapy plus bismuth (TTPB), comprising a proton pump inhibitor (PPI), two antibiotics, and bismuth, is widely used to eradicate Helicobacter pylori (H. pylori), eradication rates have been suboptimal. Potassium-competitive acid blockers (P-CABs) offer stronger and more stable gastric acid inhibition compared to PPIs.

The association between hemoglobin-to-red cell distribution width ratio and asthma and asthma exacerbations: a cross-sectional study.

Background: The hemoglobin-to-red cell distribution width ratio (HRR) is a newly identified inflammatory biomarker associated with various inflammatory diseases. Asthma is a major global health burden and an inflammatory airway disease significantly affected by inflammation. This study primarily aims to evaluate the relationship between HRR and asthma, as well as asthma-related outcomes, including stable asthma and asthma exacerbations in the past year.

Clinical significance of N-terminal pro-brain natriuretic peptide, adrenomedullin, and cardiac troponin I in paediatric patients with CHD and heart failure: a retrospective study.

Introduction: Heart failure is the most common complication of congenital heart disease (CHD), characterized by high morbidity and mortality. Early recognition and intervention are crucial for improving outcomes in pediatric patients with CHD and heart failure. This study aimed to analyze the clinical value of N-terminal pro-brain natriuretic peptide, adrenomedullin, and cardiac troponin I in pediatric patients with CHD and heart failure.

The Crosstalk Between Protective and Detrimental Interleukin (IL)-1 Family of Cytokines in Alzheimer's Disease.

Alzheimer's disease (AD) is a long-term, progressive, degenerative disorder. One of the most important pathological characteristics of AD is the deposition of β-amyliod (Aβ) peptide, which initiates a spectrum of cerebral neuroinflammation. Vascular changes also play an important role in the pathophysiology of the disease.

Estimated pulse wave velocity as a potential predictor of albuminuria in hypertension.

Background: Increased arterial stiffness is an important marker of target organ damage in hypertension. Estimated pulse wave velocity (ePWV) is a noninvasive assessment of arterial stiffness based on blood pressure and age calculations, but its association with albuminuria, an early indicator of renal function impairment, still needs to be validated. The aim of this study was to investigate the association of ePWV with albuminuria and its dose-response properties in hypertensive patients.

Diagnosis and Management of Large Extraosseous Myxoid Chondrosarcoma of the Buttocks: A Case Report.

BACKGROUND Extraskeletal chondrosarcoma is a rare soft tissue sarcoma with no characteristic imaging and clinical manifestations. Therefore, early preoperative diagnosis is difficult and ultimately depends on postoperative pathology and genetic diagnosis. CASE REPORT A 67-year-old man presented with a huge buttock tumor.

The Protective Activity of Apigenin Against Bone and Cartilage Diseases.

Bone and cartilage diseases have become the leading causes of joint disability due to the destruction of bone and cartilage. No effective drugs are available to cure bone and cartilage diseases. Exploring natural compounds as therapeutic alternatives shows promise.

Exploration of neuroprotective strategies in patients with acute promyelocytic leukemia complicated by cerebral hemorrhage.

Acute promyelocytic leukemia (APL) is a highly lethal hematological malignancy associated with various complications, among which cerebral hemorrhage is one of the most severe. Implementing effective neuroprotective strategies for APL patients experiencing cerebral hemorrhage is crucial. This article aims to explore the application of neuroprotective strategies in these patients, analyzing their mechanisms, clinical efficacy, and future research directions.

Investigating the Causal Role of Neurotrophic Factors in Low Back Pain and Sciatica: A Mendelian Randomization Study.

Background: Low back pain (LBP) and sciatica are among the most prevalent musculoskeletal disorders, leading to significant disability and an economic burden. Neurotrophic factors, including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and glial cell-derived neurotrophic factor (GDNF), play critical roles in pain modulation and neuronal function. While NGF-targeting monoclonal antibodies have shown potential in treating chronic pain, their efficacy and safety remain under debate.

Nose-to-brain delivery of biomineralized silk fibroin nanoparticles synergistically extinguish neuroinflammation for efficient depressive-like symptoms alleviation.

Major depressive disorder (MDD) represents a prevalent psychiatric health problem with typically neuroinflammation and microglial overactivation. Efficiently delivering therapeutic medications across the blood-brain barrier for neuroinflammation depletion remains currently unavailable. Hence, we developed the biomineralized silk fibroin nanoparticles (CaSF@TB) for intranasal delivery of tetrahydroxystilbene glucoside and berberine to target the brain in addressing depressive disorders.

Preoperative ternary classification using DCE-MRI radiomics and machine learning for HCC, ICC, and HIPT.

Objectives: This study develops a machine learning model using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) radiomics and clinical data to preoperatively differentiate hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC), and hepatic inflammatory pseudotumor (HIPT), addressing limitations of conventional diagnostics.

Materials And Methods: This retrospective study included 280 patients (HCC = 160, ICC = 80, HIPT = 40) who underwent DCE-MRI from 2008 to 2024 at three hospitals. Radiomics features and clinical data were extracted and analyzed using LASSO regression and machine learning algorithms (Logistic Regression, Random Forest, and Extreme Gradient Boosting), with class weighting (HCC:ICC:HIPT = 1:2:4) to address class imbalance.

Multifunctional Swellable Polymeric Aerogel with Thrombin and Maxpower for Rapid Hemostasis and Antibacterial Protection in Gastrointestinal Trauma.

Uncontrolled deep arterial bleeding and perforated wounds in the gastrointestinal (GI) tract present significant clinical challenges, especially in emergency settings. In this study, a multifunctional polymeric aerogel (CPP), composed of carboxymethyl chitosan (CMCS), poly-γ-glutamic acid (γ-PGA), and polyvinylpyrrolidone (PVP), is developed to address the dual needs of rapid hemostasis and infection prevention. The CPP aerogel exhibits excellent swelling behavior, enabling rapid blood absorption and mechanical expansion to establish a physical barrier.

Vitamin D as a Key Mediator Between C-reactive Protein to Albumin Ratio and Congestive Heart Failure in an Elderly Population: An Innovative Exploration Using the NHANES Database.

Background: The C-reactive protein-to-albumin ratio (CAR), a marker of inflammation and nutritional status (calculated as C-reactive protein [CRP]/albumin [ALB]), is associated with increased mortality in congestive heart failure (CHF). However, whether vitamin D modulates the CAR-CHF relationship remains unclear. Using data from the National Health and Nutrition Examination Survey (NHANES), this study aimed to investigate the mediating role of vitamin D in the association between CAR and CHF among older adults, with implications for cardiovascular disease prevention.