Operational developments at the : improved production timelines, new policy introduction, and senior editorial team updates.

In our editorial in the January/April 2023 issue of the (), we spoke of the challenges we faced when we took on the co-lead editor roles. At the end of that editorial, we stated our intention to get the publishing schedule back on track and to finally tackle other projects. And while it took us some time to report it, we are pleased to share that, in the publication year of 2024, resumed its regular quarterly publishing schedule.

Intraocular Pressure Outcomes Following Suprachoroidal Triamcinolone Acetonide in Patients With Glaucoma, Ocular Hypertension, or Steroid Response.

To examine the effect of suprachoroidal triamcinolone acetonide on intraocular pressure (IOP) in patients with a known history of glaucoma, ocular hypertension, or steroid response. This was a multicenter, retrospective cohort study examining patients with glaucoma, ocular hypertension, or a prior steroid response who received suprachoroidal triamcinolone acetonide between February 1, 2022, and December 31, 2023. Patient charts were reviewed to record IOP at the time of treatment with suprachoroidal triamcinolone acetonide and at follow-up.

Associations of High Attenuation Area-related Proteomic Biomarkers with Fibrotic or Subpleural Interstitial Lung Abnormalities.

Rationale: High attenuation area (HAA) is a computed tomography (CT) tool that correlates with lung inflammation and fibrosis. Systemic molecular correlates of HAA (e.g.

Identifying Neoplastic Versus Non-neoplastic Pancreatic Cystic Lesions-What Is the Current Evidence?

Background: The widespread use of modern, high-resolution cross-sectional imaging has led to increased detection of pancreatic cystic lesions (PCLs), which have varying malignant potential. While most require periodic radiographic surveillance, some warrant biopsy or surgical excision.

Methods: We conducted a narrative review of the literature focusing on the diagnostic accuracy of imaging and the role of endoscopic and molecular tools in PCL evaluation.

Fatty pancreas disease and the risk of future diseases of the exocrine pancreas: a US matched cohort study.

Background: Fatty pancreas disease (FPD), marked by excess fat within the pancreas, is often incidentally detected on imaging. Despite recognized metabolic links, its clinical significance remains unclear. More granular data from large, well-characterized U.

Characteristics of "Very Early" Intrahepatic Cholangiocarcinoma Undergoing Liver Resection and Its Relationship With Carbohydrate Antigen 19-9.

Introduction: The concept of "very early" ICC ( ≤ 2 cm, single tumor) has been introduced in the context of LT. Due to the limited number of patients in this subset, the characteristics and long-term outcomes have been ill-defined. We sought to assess long-term outcomes of very early ICC patients undergoing liver resection using a large, multi-institutional database.

In-Hospital Mortality Risk Among Transfers to Cardiac Intensive Care Units.

Background: Patients treated in tertiary cardiac intensive care units (CICUs) often arrive via transfer from other hospitals. This "transfer population" is poorly described and has been largely excluded from trials in critical care.

Objectives: The aim of this study was to characterize patients who are transferred from other hospitals to advanced CICUs.

Radiotherapy-the not-so-insignificant contributor to cancer-associated venous thrombosis.

Venous thromboembolism is a well-established complication in patients with cancer and a leading cause of morbidity and mortality in these subjects. However, the role of radiotherapy in cancer-associated venous thromboembolism (CAT) remains less clearly defined. The incidence of CAT in this population varies widely, with several large-scale studies suggesting an association.

Leveraging artificial intelligence for prediction of pulmonary hemorrhage in preterm infants.

Objectives: To identify clinical variables and indicators associated with pulmonary hemorrhage in preterm infants.

Methods: This case-control study included inborn infants <32 weeks. Data were collected in 12-h epochs from birth until hemorrhage onset or up to 72 h for controls.

Effects of Wise Pattern Versus Vertical Approach on The Outcomes of Superomedial Pedicle Breast Reduction: Systematic Review and Pooled Analysis.

Introduction: Superomedial pedicle breast reduction combined with a Wise pattern or vertical skin resection has become more popular recently. This review aims to investigate the role of the type of skin resection that may alter the outcomes of superomedial breast reduction surgeries.

Methods: We reviewed MEDLINE and Embase databases for articles investigating superomedial pedicle breast reduction outcomes.

Shouldice vs Lichtenstein Inguinal Hernia Repair: A Propensity Score-Matched Analysis Comparing Early Postoperative Pain and Quality of Life.

Background: Tissue-based inguinal hernia repairs (IHRs), such as the Shouldice technique, are an acceptable alternative to mesh-based repairs in appropriately selected patients; however, they are often thought to be more painful than tension free repairs in the early postoperative period. We aimed to compare short-term pain and quality of life (QoL) between the Shouldice and Lichtenstein techniques for IHR.

Methods: The Abdominal Core Health Quality Collaborative (ACHQC) database was queried for patients who underwent open IHR between January 2017 and April 2023.

Self-Perceived Hearing Outcomes with Radiation and Cisplatin or Radiation and Cetuximab for Patients with HPV-Positive Oropharyngeal Cancer - Results from xxxxx.

Purpose: xxxx was a noninferiority phase 3 trial comparing the efficacy of radiation with either cisplatin (RT+Cis) or cetuximab (RT+Cetux) for patients with HPV+ oropharyngeal cancer (OPC). Perceived hearing handicap was included as a patient reported outcome (PRO) secondary endpoint. The primary hypothesis was that perceived hearing handicap would be greater for patients receiving RT+Cis compared to RT+Cetux.

Simulated Wear and Fatigue Performance of Cobalt-Chrome-Molybdenum and Co-Cr-Free Nitrided Titanium Femoral Components in Primary Total Knee Arthroplasty.

Cobalt-chromium-molybdenum (Co-Cr-Mo) femoral components are widely used in total knee arthroplasty (TKA) due to their mechanical strength and wear performance. However, concerns regarding corrosion, metal ion release, and hypersensitivity have prompted the development of alternative materials, including nitrided titanium-aluminum-vanadium (nTi-6Al-4V). This study aimed to compare the simulated wear performance of Co-Cr-Mo and nTi-6Al-4V femoral components when articulated against conventional polyethylene articular surface bearings and evaluate the fatigue performance of nTi-6Al-4V components.

Comparative Analysis of Certification Programs for Robotic Total Knee Arthroplasty: A Review of Training Requirements Across Major Platforms.

As robotic systems become increasingly utilized in total knee arthroplasty (TKA), structured certification programs are necessary to ensure that surgeons are proficiently trained for safe and effective use. This review examines the certification requirements for six major robotic TKA systems: Zimmer Biomet's ROSA, Stryker's Mako, Smith & Nephew's CORI, Depuy Synthes' Velys, Corin's ApolloKnee, and Think Surgical's TSolution One and TMINI. However, variation in certification structures and training requirements between each system is evident.

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Venous thromboembolism (VTE) is a significant global health concern, with >1 million cases annually in the United States, making it a leading cause of preventable hospital-related deaths. Advances in genetic research, particularly genome-wide association studies, have demonstrated the polygenic nature of VTE by identifying numerous single-nucleotide polymorphisms associated with susceptibility. The polygenic risk score (PRS), which aggregates the effects of multiple single-nucleotide polymorphisms, has emerged as a valuable tool for improving VTE risk assessment.

BCL-xL dependency in chromophobe renal cell carcinoma.

Chromophobe renal cell carcinoma (ChRCC) is the third most common subtype of kidney cancer, with limited therapeutic options. Using BH3 profiling to screen ChRCC-derived cell lines, we discovered that BH3 peptides targeting BCL-xL promote apoptosis in ChRCC. Downregulation of BCL2L1 is sufficient to induce apoptosis in ChRCC-derived cells, consistent with our screening results.

Circulating genomic landscape following cyclin-dependent kinase 4/6 inhibitors exposure in HR + /HER2- metastatic breast cancer: a retrospective multi-institutional Consortium analysis.

Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) plus endocrine therapy (ET) are the mainstay of treatment for hormone receptor positive, HER2 negative (HR + /HER2-) metastatic breast cancer (MBC). However, disease progression is inevitable and unveiling resistance mechanisms is crucial to guide post-CDK4/6i therapeutic strategies. In this study, we retrospectively analyzed a real-world, multi-institutional cohort of patients with HR + /HER2- MBC characterized by circulating tumor DNA (ctDNA) through next-generation sequencing (NGS) before starting second-line treatment.

Challenges and opportunities on achieving an adequate delivery efficiency and immunogenicity with peptide-based anticancer vaccines.

Peptide vaccines are based on small peptide segments that contain antigenic epitopes recognizable by immune cells. Unlike traditional vaccines, they include only specific antigenic epitopes rather than entire pathogens or proteins. They are recognized, internalized, processed, and presented by antigen-presenting cells, such as dendritic cells, and subsequently presented to T cells, triggering an immune response.