Neuropsychiatric lupus: a myriad of symptoms requires a myriad of models.

Neuropsychiatric lupus (NPSLE) is believed to manifest in 30-40% of SLE patients, with symptoms spanning from fatigue and anxiety to depression, cognitive impairment, and psychosis. Over the past decades, it has become clear that most animal models of SLE also present with some level of NPSLE-like disease. Similar to the diversity of presentations among NPSLE patients, symptoms of NPSLE differ between animal models, likely due to their fixed genetic background.

In-Hospital Outcomes and Readmissions in High-Risk Pulmonary Embolism Patients Requiring Extracorporeal Membrane Oxygenation Support.

There are limited data on the use of extracorporeal membrane oxygenation (ECMO) in high-risk pulmonary embolism (PE) patients. We analyzed the use of ECMO in high-risk PE patients (defined as requiring vasopressors, with cardiogenic shock, or cardiac arrest) using the National Readmission Database (2016-2020) to assess the outcomes of in-hospital mortality, hospitalization costs and length of stay (LOS). Among 130,486 patients, 1,685 (1.

Semaglutide-Induced Hepatic Injury: A Rare Case of Drug Induced Liver Injury.

Semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, is widely used for type 2 diabetes mellitus and has demonstrated hepatoprotective effects. However, this case highlights a rare instance of possible drug-induced liver injury (DILI) temporally linked to its use. A middle-aged male with well-controlled diabetes, social alcohol use, and no history of liver disease presented with asymptomatic elevations in alanine transaminase (ALT) and aspartate aminotransferase (AST).

"Testicular Torsion in a Child With CPT-1 Deficiency and History of Viral Myositis: Anesthesia Considerations".

Tailored anesthetic management is crucial for pediatric patients with inborn metabolic disorders like CPT-1 deficiency and conditions, such as viral myositis. Avoiding inhalational anesthetics and succinylcholine, using glucose infusion, safe anesthetics, and appropriate monitoring are essential to prevent metabolic crises and malignant hyperthermia during surgery, ensuring patient safety.

Safety of bariatric surgery in HIV-positive patients on antiretroviral therapy.

Background: Obesity among people living with HIV (PLWH) is rising, but the safety of bariatric surgery in this population remains unclear. Preliminary evidence suggests that bariatric surgery does not exacerbate HIV progression or elevate postoperative risk.

Objectives: This study aimed to compare the risk of all-cause mortality and inpatient admission between HIV-positive and HIV-negative patients undergoing bariatric surgery.

Elevated Perioperative Morbidity After Parathyroidectomy for Calciphylaxis Patients: A Nationwide Retrospective Observational Study.

Introduction: Calcific uremic arteriolopathy (CUA), also known as calciphylaxis, is a rare and potentially lethal condition associated with longstanding renal failure. It is defined by calcium and parathyroid hormone dysregulation, which leads to vascular calcification, painful skin necrosis, and high rates of sepsis-driven mortality. Although the mainstay treatment is medical therapy and supportive care, severe or recalcitrant cases will require parathyroidectomy, a modality associated with high perioperative complication rates of up to 40%.

Cellular and enzymatic features of thrombi in humans are vascular bed dependent.

Mechanisms behind vascular remodeling following thrombosis are unclear. Although acute arterial thrombosis in the cerebrovascular circulation has devastating consequences and requires immediate attention, the management of venous thromboembolism (VTE) varies significantly. Our goal was to determine the molecular signatures and cellular content of thrombus extracted using a catheter to gain insight into vascular remodeling.

Genome-wide association analyses reveal susceptibility variants linked to Parkinson's disease in the South African population using inferred global and local ancestry.

Genome-wide association studies (GWAS) have been successful in identifying over 100 loci associated with Parkinson's disease (PD) susceptibility. However, the majority of these studies have focused on European cohorts with few including diverse ancestries. Using genotyped and imputed data from 691 South African PD cases and 826 controls, we conducted a conventional GWAS, two local ancestry GWAS (LA-GWAS) approaches (one using local ancestry as a covariate and the other separating the dosage per ancestry), and an association analysis to identify regions of homozygosity associated with PD status.

Segmental versus Extended Resection for Colon Cancer in Lynch Syndrome.

Lynch's syndrome is a common cause of hereditary colorectal cancer (CRC), resulting in higher risk of CRC and development of subsequent, metachronous CRC (mCRC). Beyond treating the primary cancer, surgeons and patients must decide on whether performing an extended colectomy, to reduce the risk of mCRC, is worth the change in function that comes with the larger operation. Considerations include likelihood for mCRC, morbidity and quality of life after resection, impact of pathogenic variant, and certain other cancer risk reduction options.

Impact of GLP-1 Receptor Agonists on Whole-Gut Gastrointestinal Motility Using Wireless Motility Capsule: A Descriptive Single-Center Case Series.

This retrospective case series investigates the impact of GLP-1 receptor agonists (GLP-1RAs) on whole-gut gastrointestinal motility using wireless motility capsule testing. We analyzed 10 patients on GLP-1RAs who underwent wireless motility capsule testing for constipation or gastroparesis to assess gastric, small bowel, and colonic transit times. Delayed gastric emptying time was observed in 80% of patients, whereas delayed whole-gut transit time was noted in 44% of patients.

From pathophysiology to novel approaches for obesity-associated hypertension.

Obesity is a rapidly growing epidemic affecting >15% of the global adult population and has considerable clinical consequences and comorbidities, including hypertension, diabetes mellitus, cardiovascular and cerebrovascular diseases and chronic kidney disease. There is a strong association between obesity or body mass index and high blood pressure (BP) in epidemiological studies while the underlying pathophysiological events linking those conditions are not fully elucidated. Hypothetical mechanisms include a sedentary lifestyle and excess intake of processed foods that contribute to obesity, overactivation of the renin-angiotensin-aldosterone and sympathetic nervous systems, inflammation, altered adipokine homeostasis and the fatty kidney hypothesis involving adipose tissue accumulation in the renal sinus and perirenal space.

Bladder cancer microbiome and its association with chemoresponse.

Background: The microbiome is widely known to cause come types of cancer, modify cancer biology, and impact therapeutic efficacy. Despite the urinary microbiome being one of the most clinically significant microbiomes in human health, it is one of the least well-described.

Methods And Materials: To begin to annotate the urinary microbiome present in bladder cancers, we analyzed human genome-filtered sequencing data from the Cancer Genome Atlas (TCGA) from 116 tumors (duplicates from 22 tumors), 22 adjacent normal bladder tissues, and 99 blood samples to classify reads originating from known microbiota.

Lung Transplantation in Men With High-Risk Prostate Cancer.

Introduction: Transplantation in patients with active malignancies is controversial due to concerns about immunosuppression accelerating cancer progression and ethical allocation of donor organs. Prostate adenocarcinoma has a non-immunogenic profile and can respond to temporizing non-chemotherapeutic treatments such as androgen deprivation therapy (ADT). We examine two cases of lung transplantation (LT) in patients with high-risk prostate cancer (PCa) diagnosed during pretransplant evaluation, in whom transplantation was prioritized before definitive cancer treatment.

Prevention's Price-30-Day Outcomes of Risk-Reducing Mastectomy and Immediate Free Flap Breast Reconstruction.

Background: Risk-reducing mastectomy (RRM) with free flap breast reconstruction (FFBR) is increasingly utilized for breast cancer prevention. While its oncological benefits are well-established, data on perioperative safety remain limited. To address this gap, we analyzed postoperative outcomes and risk factors for complications utilizing the American college of surgeons national surgical quality improvement program (ACS-NSQIP) database.

A multinational cross-sectional study on the prevalence and predictors of long COVID across 33 countries.

The symptoms of long COVID (LC) can be debilitating and may be associated with anxiety, social stigma, and quality of life deterioration. Identifying patients at risk of LC is important to offer follow-up care and plan population-level public health measures. The current multinational study aimed to assess the prevalence and predictors of LC in the general population.

Minimum Imaging Sets for Diagnosis, Activity Assessment, and Complications in Noninfectious Posterior Uveitis - Multimodal Imaging in Uveitis (MUV) Task Force Report 9.

Purpose: To evaluate a minimum imaging set (MIS) to support ophthalmologists in diagnosing, monitoring disease activity, and identifying disease-specific complications for six types of noninfectious posterior uveitides (NIPU).

Design: Visual questionnaire answered live by a group of ophthalmologists.

Participants: International group of ophthalmologists, including uveitis experts, medical retina experts, general ophthalmologists, and ophthalmologists-in-training.

Clinical Reasoning and Diagnostic Errors.

Clinical reasoning has many different definitions subsuming many different processes and theories. Clinical reasoning can be generally conceived of as including both diagnostic reasoning and management reasoning. Safe, effective, efficient, and judicious diagnosis is the cornerstone of high-quality health care; yet, the diagnostic process is complex and fraught with opportunities for diagnostic error.

Catheter-Associated Urinary Tract Infection, Central Line-Associated Bloodstream Infection, and Clostridioides difficile Infection-An Overview.

Central line-associated bloodstream infection, Clostridioides difficile infection, and catheter-associated urinary tract infection are commonly encountered hospital-acquired infections. This article provides a pragmatic overview of these infections.

A phase 3, multicenter, randomized, placebo-controlled trial of monthly oral ibrexafungerp to reduce the incidence of recurrent vulvovaginal candidiasis.

Background: Recurrent vulvovaginal candidiasis develops in 5% to 9% of people assigned female at birth and has a serious impact on quality of life. Oral ibrexafungerp is a first-in-class, nonazole, triterpenoid antifungal approved in the United States for the treatment of postmenarchal females with acute vulvovaginal candidiasis and for the reduction in the incidence of recurrent vulvovaginal candidiasis.

Objective: This phase 3 study (CANDLE) describes the efficacy and safety of monthly oral ibrexafungerp vs placebo for reducing the incidence of recurrent vulvovaginal candidiasis.