Design and control of LCC DVR.

Providing quality power without any voltage fluctuations is the responsibility of any utility. Among the series active voltage compensators, Dynamic Voltage Restorer (DVR) is the most preferred in an electrical power distribution network. Three-phase unbalance sag as well as balanced voltage sag/swell can be effectively compensated using a DVR.

Placental miRNA profiling in assisted reproductive technology (ART) pregnancies.

Purpose: Assisted reproductive technology (ART) procedures are associated with placental dysfunction involving dysregulation of several molecular factors and pathways. MicroRNAs (miRNAs) are crucial epigenetic regulators involved in placental development and function. The objective was to identify differential miRNAs in the placentae of women conceived by ART procedures and explore their role by pathway analysis.

AgCV: An Agentic framework for automating computer vision application.

This paper proposed the Agentic Computer Vision (AgCV) framework designed to automate complex computer vision (CV) tasks through autonomous agents that communicate through Graphical User Interface (GUI). The AgCV framework leverages LangGraph, natural language processing, deep learning, and data science to build adaptive, user-driven CV pipelines. In the proposed AgCV each Agent works on a particular task ranging from object identification and classification to image segmentation.

Inhibition of xpt Guanine Riboswitch by a synthetic nucleoside analog.

Riboswitches are structured elements predominantly found in the 5'-untranslated region of many bacterial mRNA. These noncoding RNA regions play a vital role in bacterial metabolism and overall function. Each riboswitch binds to a specific small molecule and causes conformational changes in the mRNA leading to regulation of transcription or translation.

Breaking barrier of binding buffer in colorimetric aptasensing of tetracycline in food fish using peroxidase mimic gold NanoZyme.

Tetracycline is extensively used in aquaculture as a therapeutic agent that needs to be monitored due to food safety concerns. Aptasensing has been revealed as a suitable diagnostic platform for tetracycline sensing in food matrix due to its quick, low cost and robust nature. But, the colorimetric aptasensing of tetracycline employing the peroxidase activity of gold nanoparticles (AuNPs) to 3,3,5,5-tetramethylbenzidine (TMB) was unsuitable until now owing to the aptamer-specific alkaline binding buffer.

Peroxidase mimic feroxyhyte (FeOOH) nanoparticles enabled highly specific colorimetric detection of arsenate in water and fish.

Arsenic poses a serious health risk to humans. Hence, a simple and robust analytical approach for monitoring arsenic levels in water and food matrixes is required. We present a simple and rapid approach for quantifying arsenate in water and fish using feroxyhyte (FeOOH) nanoparticles as a sensor probe.

Corrigendum to "Threats of zoonotic pathogens in food chain: Current status and gaps in India" [Heliyon Volume 11, Issue 1, 15 January 2025, e41240].

[This corrects the article DOI: 10.1016/j.heliyon.

Uncovering Taxiphyllin in bamboo shoots: An analytical perspective.

Bamboo shoots, a staple in Asian diets, particularly in India, China, Japan, and Southeast Asia, are valued for their rich nutrients and health benefits. However, they contain cyanogenic glycosides, primarily Taxiphyllin, posing toxicity risks if improperly consumed. This review examines bamboo shoots' nutritional profile, geographical consumption patterns, and the role of Taxiphyllin.

Construction of an immunoinformatics-based multi-epitope vaccine candidate targeting Kyasanur forest disease virus.

Kyasanur forest disease (KFD) is one of the neglected tick-borne viral zoonoses. KFD virus (KFDV) was initially considered endemic to the Western Ghats region of Karnataka state in India. Over the years, there have been reports of its spread to newer areas within and outside Karnataka.

Multimodal machine learning for deception detection using behavioral and physiological data.

Deception detection is crucial in domains like national security, privacy, judiciary, and courtroom trials. Differentiating truth from lies is inherently challenging due to many complex, diversified behavioural, physiological and cognitive aspects. Traditional lie detector tests (polygraphs) have been widely used but remain controversial due to scientific, ethical, and practical concerns.

Understanding the conformational dynamics of PI3Kα due to helical domain mutations: insights from Markov state model analysis.

Phosphoinositide 3-kinases (PI3Ks) phosphorylate phosphoinositides on the membrane, which act as secondary signals for various cellular processes. PI3Kα, a heterodimer of the p110α catalytic subunit and the p85α regulatory subunit, is activated by growth factor receptors or mutations. Among these mutations, E545K present in the helical domain is strongly associated with cancer, and is known to disrupt interactions between the regulatory and catalytic subunits, leading to its constitutive activation.

Differential producibility analysis reveals drug-associated carbon and nitrogen metabolite expressions in Mycobacterium tuberculosis.

Mycobacterium tuberculosis (Mtb) is one of the world's successful pathogens that flexibly adapts its metabolic nature during infection of the host, and in response to drugs. Here we used genome scale metabolic modelling coupled with differential producibility analysis (DPA) to translate RNA-seq datasets into metabolite signals and identified drug-associated metabolic response profiles. We tested four tuberculosis (TB) drugs bedaquiline (BDQ), isoniazid (INH), rifampicin (RIF), and clarithromycin (CLA); conducted RNA-seq experiments of Mtb exposed to the individual drugs at subinhibitory concentrations, followed by DPA of gene expression data to map up and downregulated metabolites.

Threats of zoonotic pathogens in food chain: Current status and gaps in India.

Background: Public health is seriously threatened by transmission of zoonotic infection through the food chain. Factors like increasing population, deforestation, high demand for animal protein, and trade of sub-clinically infected animals are the main causes of the spread of infections from asymptomatic animals to humans. Despite several national programs like (The Clean India Mission) prevention of open defecation and water, sanitation, and hygiene (WASH), the incidence of diarrhoeal diseases remains high in India.

Resting state EEG microstate profiling and a machine-learning based classifier model in epilepsy.

Unlabelled: Electroencephalography-based (EEG) microstate analysis is a promising and widely studied method in which spontaneous cerebral activity is segmented into sub second level quasi-stable states and analyzed. Currently it is being widely explored due to increasing evidence of the association of microstates with cognitive functioning and large-scale brain networks identified by functional magnetic resonance imaging (fMRI). In our study using the four archetypal microstates (A, B, C and D), we investigated the changes in resting state EEG microstate dynamics in persons with temporal lobe epilepsy (TLE) and idiopathic generalized epilepsy (IGE) compared to healthy controls (HC).

A Study Modeling Bridged Nucleic Acid-Based ASOs and Their Impact on the Structure and Stability of ASO/RNA Duplexes.

Antisense medications treat diseases that cannot be treated using traditional pharmacological technologies. Nucleotide monomers of bare and phosphorothioate (PS)-modified LNA, N-MeO-amino-BNA, 2',4'-BNA[NH], 2',4'-BNA[NMe], and N-Me-aminooxy-BNA antisense modifications were considered for a detailed DFT-based quantum chemical study to estimate their molecular-level structural and electronic properties. Oligomer hybrid duplex stability is described by performing an elaborate MD simulation study by incorporating the PS-LNA and PS-BNA antisense modifications onto 14-mer ASO/RNA hybrid gapmer type duplexes targeting protein PTEN mRNA nucleic acid sequence (5'--3'/3'-GAAUCGUGACCGGA-5').

Innovative technology integration: E tongue, near infrared grain tester & machine vision approaches for amylose content & quality characterization.

-tongue, machine vision and NIR systems were used to standardize the quality measurements in twenty rice genotypes grown in Highland Himalayan regions of Kashmir, in order to overcome the constraints of manual measurements. showed highest amylose content of 20.74 % and 20.

Developing a digital data platform for surveillance of food and water-borne pathogens in North East India: insight for public health advocacy.

Robust digital infrastructure is vital and the need of the hour, especially in the healthcare sector, for real-time data generation, analysis, and quick decision-making. Food- and water-borne illnesses represent a prominent cause of morbidity and mortality worldwide. India, a developing nation with diverse cultures and food practices, poses a high risk of food-borne diseases and outbreaks, yet is often underreported and ineffectively researched.

Insight into structural dynamics involved in activation mechanism of full length KRAS wild type and P-loop mutants.

KRAS protein is known to be frequently mutated in various cancers. The most common mutations being at position 12, 13 and 61. The positions 12 and 13 form part of the phosphate binding region (P-loop) of KRAS.

Early Events in βAR Dimer Dynamics Mediated by Activation-Related Microswitches.

G-Protein-Coupled Receptors (GPCRs) make up around 3-4% of the human genome and are the targets of one-third of FDA-approved drugs. GPCRs typically exist as monomers but also aggregate to form higher-order oligomers, including dimers. βAR, a pharmacologically relevant GPCR, is known to be targeted for the treatment of asthma and cardiovascular diseases.

Colorimetric detection of Cr(VI) in water using tetramethyl benzidine (TMB) as an indicator.

Hexavalent chromium (CrVI) poses a serious risk to both human and environment health. Hence, a simple, robust, and efficient analytical method must be developed to monitor the presence of Cr(VI) in the environment. The current investigation concentrated on the colorimetric detection of Cr(VI) using TMB as indicator in the presence of HO.

Modulation of Electron Push-Pull by Redox Non-Innocent Additives for Long Cycle Life Zinc Anode.

Application of an aqueous Zn-ion battery is plagued by a water-induced hydrogen evolution reaction (HER), resulting in local pH variations and an unstable electrode-electrolyte interface (EEI) with uncontrolled Zn plating and side reactions. Here, 4-methyl pyridine N-oxide (PNO) is introduced as a redox non-innocent additive that comprises a hydrophilic bipolar N-O ion pair as a coordinating ligand for Zn and a hydrophobic ─CH group at the para position of the pyridine ring that reduces water activity at the EEI, thereby enhancing stability. The N-O moiety of PNO possesses the unique functionality of an efficient push electron donor and pull electron acceptor, thus maintaining the desired pH during charging/discharging.

Estimation of genetic variation in vitiligo associated genes: Population genomics perspective.

Background: Vitiligo is an auto-immune progressive depigmentation disorder of the skin due to loss of melanocytes. Genetic risk is one of the important factors for development of vitiligo. Preponderance of vitiligo in certain ethnicities is known which can be analysed by understanding the distribution of allele frequencies across normal populations.

Harnessing the potential of agriculture biomass: reuse, transformation and applications in energy and environment.

Biomass, an organic matter, has gained worldwide attention due to the overconsumption of fossil fuels. Biomass has emerged as a new alternative resource with implications for efficient energy production, environmental benefits and socio-economic impacts. According to the World Bioenergy Association, biomass has accounted for 14% of the energy supply in 2016 and is expected to provide 44% of the energy demand by 2030.