Postbiotic-Mediated Obesity Reduction via Bioactive Peptide ETLVK and Gut Microbiota in HFD Mice.

Although () TCCC11824 (CGMCC 8198) has shown antiobesity effects, its active components remained unclear. This study reveals that the TCCC11824 crushed supernatant (LpS) exerts broad antiobesity activities in high-fat diet (HFD)-induced obese mice. LpS significantly improved blood lipid profiles, reduced hepatic injury, and suppressed inflammation in liver and epididymal fat.

VCF2Dis: an ultra-fast and efficient tool to calculate pairwise genetic distance and construct population phylogeny from VCF files.

Background: Genetic distance metrics are crucial for understanding the evolutionary relationships and population structure of organisms. Progress in next-generation sequencing technology has given rise of genotyping data of thousands of individuals. The standard Variant Call Format (VCF) is widely used to store genomic variation information, but calculating genetic distance and constructing population phylogeny directly from large VCF files can be challenging.

Tissue distribution, excretion characteristics and metabolic profiling studies of oxypeucedanin in rats using liquid chromatography tandem mass spectrometry.

Oxypeucedanin (OPD) is a linear furanocoumarin extracted from Chinese herbs, which has been reported to exhibit various pharmacological effects such as analgesia, antitussive, anticancer and anti-inflammatory activities. In this paper, the tissue distribution, excretion and metabolism characteristics of OPD in rat was conducted in order to better understand this compound and for potential development of OPD as a medicine. We first used the established HPLC/MS/MS method to examine the plasma protein binding rate and the tissue distribution of OPD in rats after oral administration.

Bright and sensitive red voltage indicators for imaging action potentials in brain slices and pancreatic islets.

Genetically encoded voltage indicators (GEVIs) allow the direct visualization of cellular membrane potential at the millisecond time scale. Among these, red-emitting GEVIs have been reported to support multichannel recordings and manipulation of cellular activities with reduced autofluorescence background. However, the limited sensitivity and dimness of existing red GEVIs have restricted their applications in neuroscience.