Prices and Clinical Benefit of National Price-Negotiated Anticancer Medicines in China.

Background: High prices of anticancer medicines have increased the economic burden for both patients and health insurance systems. Since 2017, China has implemented national price negotiations for medicines, relying on evidence from health technology assessments. We aim to assess the relation between negotiated price and value of anticancer medicines listed in China's National Reimbursement Drug List (NRDL).

Comparative evaluation of miniaturized and conventional NIR spectrophotometer for estimation of fatty acids in cheeses.

The miniaturization of near-infrared spectrometers has been growing rapidly. Several designs are now available, but there is a lack of understanding of how spectral data from these designs are affected by complex matrices and what are the limitations when compared to established systems. This study compares a popular miniaturized NIR device based on Hadamard-transform spectrometer (named miniaturized NIR) with a system based on dispersive spectrometer (named handheld-NIR) to assess: 1) their predictive performance; 2) the effect of a complex matrix on the performance, and 3) ability to discriminate multiples compounds in that matrix.

Sustainable management of plastic wastes in COVID-19 pandemic: The biochar solution.

To prevent the COVID-19 transmission, personal protective equipment (PPE) and packaging materials have been extensively used but often managed inappropriately, generating huge amount of plastic waste. In this review, we comprehensively discussed the plastic products utilized and the types and amounts of plastic waste generated since the outbreak of COVID-19, and reviewed the potential treatments for these plastic wastes. Upcycling of plastic waste into biochar was addressed from the perspectives of both environmental protection and practical applications, which can be verified as promising materials for environmental protections and energy storages.

Deep learning accurately predicts food categories and nutrients based on ingredient statements.

Determining attributes such as classification, creating taxonomies and nutrients for foods can be a challenging and resource-intensive task, albeit important for a better understanding of foods. In this study, a novel dataset, 134 k BFPD, was collected from USDA Branded Food Products Database with modification and labeled with three food taxonomy and nutrient values and became an artificial intelligence (AI) dataset that covered the largest food types to date. Overall, the Multi-Layer Perceptron (MLP)-TF-SE method obtained the highest learning efficiency for food natural language processing tasks using AI, which achieved up to 99% accuracy for food classification and 0.

From "Human-to-Human" to "Human-to-Non-human" - Influence Factors of Artificial Intelligence-Enabled Consumer Value Co-creation Behavior.

The emergence of artificial intelligence (AI) has changed traditional methods of value co-creation. Diverging from traditional methods, this study discusses the influencing factors of AI-supported consumer value co-creation from the perspective of human-to-non-human interactions. This study adopts the stimulus-organism-response framework with consumer engagement (CE) as the intermediary to explore the impact of consumers' personal subjective factors, community factors, and perceptions of AI technology on their value co-creating behaviors.

Shared genetic components between metabolic syndrome and schizophrenia: Genetic correlation using multipopulation data sets.

Aim: The genetic relationship between schizophrenia (SCZ) and other nonpsychiatric disorders remains largely unknown. We examined the shared genetic components between these disorders based on multipopulation data sets.

Methods: We used two data sets for East Asian (EAS) and European (EUR) samples.

Effects of Stores' Environmental Components on Chinese Consumers' Emotions and Intentions to Purchase Luxury Brands: Integrating Partial Least Squares-Structural Equation Modeling and Fuzzy-Set Qualitative Comparative Analysis Approaches.

Purpose: Drawing upon the stimulus-organism-response (S-O-R) model, this paper aims to investigate the effects of stores' environmental components (i.e., lighting, cleanliness, scent, design, layout, music, and employee interaction) on Chinese consumers' emotions and intentions to purchase luxury brands.

Is short-course radiotherapy and total neoadjuvant therapy the new standard of care in locally advanced rectal cancer? A sensitivity analysis of the RAPIDO clinical trial.

Background: The results of the RAPIDO trial have been accepted as evidence in favour of short-course radiotherapy (SC-RT) followed by chemotherapy before total mesorectal excision in high-risk locally advanced rectal cancer. A noteworthy concern is that the RAPIDO trial did not ensure that all patients in the control arm received adjuvant chemotherapy. This may bias statistical estimates in favour of the experimental arm if adjuvant chemotherapy is active in rectal cancer.

Diamond in the rough: Polishing waste polyethylene terephthalate into activated carbon for CO capture.

The scientific community has believed the potential of waste PET plastics as an effective carbon precursor, however, developing PET-derived activated carbons (PETACs) for a specific application is still a challenge we are facing. To overcome the limitation, a whole chain from development method screening to experiments design, finally to sample optimization, for a sample with promising performance, is proposed in this work. By employing PETACs as CO adsorbents, the waste PET plastics, which we believed the "diamond in the rough", have been polished successfully.

Automatic Localization and Brand Detection of Cervical Spine Hardware on Radiographs Using Weakly Supervised Machine Learning.

Purpose: To develop an end-to-end pipeline to localize and identify cervical spine hardware brands on routine cervical spine radiographs.

Materials And Methods: In this single-center retrospective study, patients who received cervical spine implants between 2014 and 2018 were identified. Information on the implant model was retrieved from the surgical notes.

Shared decision making, patient-centered communication and patient satisfaction - A cross-sectional analysis.

Objectives: The integration of shared decision making (SDM) and patient-centered communication (PCC) is needed to actively involve patients in decision making. This study examined the relationship between shared decision making and patient-centered communication.

Methods: In 82 videotaped hospital outpatient consultations by 41 medical specialists from 18 disciplines, we assessed the extent of shared decision making by the OPTION score and patient-centered communication by the Four Habits Coding Scheme (4HCS), and analyzed the occurrence of a high versus low degree (above or below median) of SDM and/or PCC, and its relation to patient satisfaction scores.

Utilization of Core Values and Branding to Recruit the Best Trainees for Your Program.

Branding is a tactic which has been well described in the business literature as a way to enhance a company's reputation, promote a sense of high quality and value, and influence an individual's perception and behavior. Branding has not traditionally been explicitly used by training programs for recruitment. However, it can be used as a powerful tool to help recruit and retain candidates who will thrive in your program.

Adjusted D-dimer cutoff levels to rule out pulmonary embolism in patients hospitalized for COPD exacerbation: results from the SLICE trial.

Background: For patients with suspected pulmonary embolism (PE), age- or clinically-adjusted D-dimer threshold level can be used to define a negative test that safely excludes PE and reduces the use of imaging. However, the utility of this approach in patients hospitalized for chronic obstructive pulmonary disease (COPD) exacerbation is undefined.

Methods: We ran an analysis of the patients hospitalized for COPD exacerbation and randomized to the intervention in the SLICE trial.

Causes and countermeasure for blank absorbance increase in the ROS assay.

A reactive oxygen species (ROS) assay is an in chemico photoreactivity test listed in ICH S10 guideline and OECD Test Guideline No. 495. We currently utilize the ROS assay to assess the photosafety of cosmetic ingredients.

A Phase I Trial to Determine the Pharmacokinetics, Psychotropic Effects, and Safety Profile of a Novel Nanoparticle-Based Cannabinoid Spray for Oromucosal Delivery.

Introduction: A phase I, open-label clinical trial in healthy male subjects was conducted to assess the pharmacokinetic and safety profile of an oromucosal cannabinoid spray (AP701) containing a lipid-based nanoparticular drug formulation standardized to ∆-9-tetrahydrocannabinol (THC).

Methods: Twelve healthy male subjects received a single dose of AP701 (12 sprays) containing 3.96 mg THC.

Factors Affecting the Repurchase Intention of Organic Tea among Millennial Consumers: An Empirical Study.

The study aims to identify the factors affecting consumers' intention to repurchase organic tea in an emerging country such as Bangladesh. The study adopted the Stimulus-Organism-Response (SOR) theory, which uses seven constructs as the predictor of repurchase intention. This is a quantitative and empirical study that adopted cross-sectional survey methods.

Brand interchangeability of pepsinogen tests in the real-world setting after eradication of Helicobacter pylori: a community-based study.

Background: Serum pepsinogen (PG) is recommended as a screening test for premalignant gastric lesions. However, real-world evidence demonstrating its applicability and equivalence between different test brands is limited.

Methods: Mass screening began in 2018 in a high-risk Taiwanese population after eradication of Helicobacter pylori, with the first stage of two PG tests (GastroPanel, Helsinki, Finland and LZ-Test, Tokyo, Japan) and the second stage of endoscopy.

Mitochondrion-targeted supramolecular "nano-boat" simultaneously inhibiting dual energy metabolism for tumor selective and synergistic chemo-radiotherapy.

Tumor energy metabolism has been a well-appreciated target of cancer therapy; however, the metabolism change of cancer cells between oxidative phosphorylation and glycolysis poses a challenge to the above. In this study, we constructed an innovative mitochondrion-targeted supramolecular "nano-boat" based on peptide self-assembly for tumor combined chemo-radiotherapy by simultaneously inhibiting the dual energy metabolism. A lipophilic self-assembled peptide and a positively charged cyclen were integrated to fabricate a brand new mitochondrion-targeted nano-platform for the first time.

Impact of taxation policy on tobacco consumption in Saudi Arabia.

Background: Taxes on tobacco products that increase the price and target demand-reduction have been shown to be an efficient means of reducing tobacco consumption. A new policy introduced in 2017 has increased the price of a 20-cigarette pack of the most popular brand to 27.50 SAR (7.

Brand-to-Generic Substitution of Buprenorphine/Naloxone Sublingual Film in Puerto Rico: A Case Study.

A 56-year-old patient with a 1-year history of stable maintenance treatment with Suboxone for opioid use disorder (OUD) was switched to a generic formulation in May of 2019. The patient reported experiencing-over the course of the following 3 months-withdrawal symptoms when switched to the Alvogen-produced generic formulation in May of 2019 and then to the Sandoz-produced version in July of that same year, she also was positive for fentanyl during that time. As a result, the buprenorphine dose was increased, and the patient was stable at this new dose using the generic versions.

Downregulation of miR-185 is a common pathogenic event in 22q11.2 deletion syndrome-related and idiopathic schizophrenia.

Schizophrenia (SCZ) is known as a complicated mental disease with an unknown etiology. The microdeletion of 22q11.2 is the most potent genetic risk factor.

Development of Duration-Based Non-Mutagenic Thresholds of Toxicological Concern (TTCs) Relevant to Parenteral Extractables and Leachables (E&Ls).

The threshold of toxicological concern (TTC), i.e., the dose of a compound lacking sufficient experimental toxicity data that is unlikely to result in an adverse health effect in humans, is important for evaluating extractables and leachables (E&Ls) as it guides analytical testing and minimizes the use of animal studies.

Brand new norms for a good old test: Northern Italy normative study of MiniMental State Examination.

Aim: Mini-Mental State Examination (MMSE) is one of the most used tests for the screening of global cognition in patients with neurological and medical disorders. Norms for the Italian version of the test were published in the 90 s; more recent norms were published in 2020 for Southern Italy only. In the present study, we computed novel adjustment coefficients, equivalent scores and cut-off value for Northern Italy (Lombardia and Veneto) and Italian speaking Switzerland.