Overall Survival with Amivantamab-Lazertinib in -Mutated Advanced NSCLC.

Background: Previous results from this phase 3 trial showed that progression-free survival among participants with previously untreated (epidermal growth factor receptor)-mutated advanced non-small-cell lung cancer (NSCLC) was significantly improved with amivantamab-lazertinib as compared with osimertinib. Results of the protocol-specified final overall survival analysis in this trial have not been reported.

Methods: We randomly assigned, in a 2:2:1 ratio, participants with previously untreated -mutated (exon 19 deletion or L858R substitution), locally advanced or metastatic NSCLC to receive amivantamab-lazertinib, osimertinib, or lazertinib.

Wildfire Smoke Induces Eye Surface Inflammation and Tear Film Changes in a Human Experimental Model.

Purpose: To investigate the short-term impact of exposure to smoke from vegetation burns on ocular surface symptoms and signs.

Methods: Woody bushfuels were burnt in an enclosed room (Flammability Laboratory, University of Tasmania, Australia) to generate particulate matter and monitored in real time (Dust Trak II). Eighteen participants (aged 20-63 years, 8 males and 10 females) fitted with respirators were seated 1.

Distinct blood volume and left ventricular adaptation to severe obesity in middle-aged adults at risk for heart failure.

Aims: Obesity is commonly hypothesized to lead to the development of heart failure (HF) in part due to increases in blood volume (BV) and left ventricular (LV) remodelling. Whether adiposity and obesity severity are associated with BV expansion and subsequent LV remodelling in middle-aged individuals at increased risk (IR) prior to the onset of HF is unknown.

Methods And Results: We analysed data from 96 middle-aged (40-64 years) non-obese (25.

Measuring the Science of Caring: A Patient-Centred Predictive Model for the Caring Interaction.

Background: The nurse-patient relationship is central to quality nursing care, yet its impact remains difficult to quantify. While existing models assess caring competencies from the perspective of nursing students and professionals, there is a lack of validated instruments incorporating direct patient feedback.

Objective: This study aimed to develop and validate the Nursing Interaction in Caring_Competence Assessment-Patient (NIC_CA-Patient) tool, a patient-centred instrument designed to measure caring interaction in nursing practice and establish a predictive model of its development from the patient's perspective.

Preclinical Investigations Toward Gd-free Molecularly Targeted Dual-Modal, MRI Dynamic (DCE-MRI)/Optical Imaging Contrast Agent for Cardiac Angiosarcoma.

Aims: Cardiac tumors are aggressive and asymptomatic in early stages, causing late diagnosis and locoregional metastasis. Currently, the standard of care uses gadolinium-based contrast agents for MRI, and the associated hypersensitivity reactions are a significant concern, such as gadolinium deposition disease. In addition, the proximity of cardiac lesions closer to vital structures complicates surgical interventions.

ICD-11 "by the people for the people": The open feedback proposal platform.

Background: ICD-11's digital architecture and granularity distinguish it from previous revisions and expand its applicability beyond mortality statistics and public health. The official ICD-11 version is updated annually. However, a separate online Maintenance Platform is continuously updated and hosts the Proposal Platform: a novel online tool that enables interested parties from all over the world to contribute to ICD-11 content.

Rapid eye movement sleep: Who needs it? Creativity mechanisms and psychiatric applications of REM sleep enhancement.

Rapid eye movement sleep (REMS) has historically been associated with anecdotal 'creative insights', possibly due to the fantastical and ostensibly illuminating nature of its associated phenomena (dreams). REMS, characterised by rapid eye movements, muscle atonia, and high-energy neuronal activity, has been linked to memory consolidation and information processing, particularly regarding the formation of novel associations or reintegration of consolidated memories into new cognitive networks. However, studies in these domains have largely used methodology which deprived subjects (animal or human) of REMS, rather than enhanced it.

Accelerated rehabilitation after proximal hamstring avulsion repair is safe and effective: Outcomes from randomized controlled trial of two different rehabilitation regimes.

Purpose: The purpose of the study was to identify the safety and effectiveness of an accelerated (AR) versus conservative (CR) rehabilitation regimen following surgical repair of proximal hamstring tendon avulsions.

Methods: This prospective randomized controlled trial (RCT) allocated patients undergoing proximal hamstring tendon repair to either a braced, partial weight-bearing rehabilitation regime (CR = 30) or an accelerated, unbraced regime, which permitted full weight-bearing as tolerated (AR = 27). Patients were evaluated pre-operatively and at 6 weeks, 3 and 6 months post-surgery, via patient-reported outcome measures (PROMs), patient satisfaction and global rating of change (GRC) scores.

Natural product-derived compounds in clinical trials and drug approvals.

Covering: January 2014-June 2025. Previous review: , 2014, , 1612Natural products (NPs) have long been foundational in medicine, from ancient herbal remedies to the discovery of transformative drugs like morphine and quinine. The mid-20th century marked a 'golden age' for antibiotic discovery from natural sources, which then expanded into other therapeutic areas.

Virtual Reality for Analgesia During Intrauterine Device Insertion: Randomized Controlled Trial.

Background: Intrauterine devices (IUDs) are safe and effective long-acting reversible contraceptive therapies that are also used as minimally invasive treatment for heavy menstrual bleeding, endometrial hyperplasia, and early-stage endometrial cancer. Despite many advantages, IUDs are underused predominantly due to patient discomfort. Although many techniques have been explored previously in the literature, there is currently little consensus on effective analgesic strategies.

Addressing the Increasing Rate of Caesarean Sections in an Australian Healthcare System: A Systems Science Approach to Identify Stakeholder Perspectives.

Caesarean section (CS) rates are increasing globally. We aimed to understand stakeholders' perspectives on factors driving CS in pregnancy care to inform areas for intervention. Stakeholders from five health services participated in three Group Model Building workshops to identify the drivers of CS and intervention opportunities.

Phase II Dose-Randomized Study of Sunvozertinib in Platinum-Pretreated Non-Small Cell Lung Cancer With Epidermal Growth Factor Receptor Exon 20 Insertion Mutations (WU-KONG1B).

Purpose: WU-KONG1B (ClinicalTrials.gov identifier: NCT03974022) is a multinational phase II, dose-randomized study to assess the antitumor efficacy of sunvozertinib in pretreated patients with advanced non-small cell lung cancer (NSCLC) with epidermal growth factor receptor () exon 20 insertion mutations (exon20ins).

Methods: Eligible patients with advanced-stage exon20ins NSCLC were randomly assigned by 1:1 ratio to receive sunvozertinib 200 mg or 300 mg once daily (200 and 300 mg-rand cohorts).

Genomic exploration of durable wheat rust resistance by integrating data from multiple worldwide populations.

Global wheat (Triticum aestivum L.) production faces significant challenges due to the destructive nature of leaf (Puccinia triticina; leaf rust [Lr]), stem (Puccinia graminis; stem rust [Sr]), and stripe (Puccinia striiformis; stripe rust [Yr]) rust diseases. Despite ongoing efforts to develop resistant varieties, these diseases remain a persistent challenge due to their highly evolving nature.

Zosteriform Primary Cutaneous Marginal Zone Lymphoma-A Case Report.

We report a case of zosteriform PCMZL presenting in a T3-T4 dermatomal distribution not previously described in the literature. Although the varicella zoster virus was not detected in this case, late diagnosis of the acute eruption of zoster or even preceding zoster 'sine herpete' cannot be excluded as antigenic triggers.

Protocols for Preparing Novel Amylose-Lipid-Polyphenol Complexes with Antioxidant Activities.

Resistant starches with additional functionalities, such as starch-polyphenol complexes, are generating great interest due to the increasing incidence of diet-related diseases. However, preparing these complexes remains a major challenge due to the incompatible structures of many natural phenolic compounds. Herein, three protocols were compared for preparing novel amylose (AM) complexes with polyphenol quercetin (Q) in the presence of lauric acid (LA).

Intravascular Basal Cell Carcinoma During Mohs Surgery.

Intravascular invasion of basal cell carcinoma is an exceedingly rare finding during Mohs' micrographic surgery. We present three cases and discuss its significance and management implications.

Boosted photocatalytic water splitting over a direct Z-scheme CdTe/CN van der Waals heterojunction: a first-principles insight into photocatalytic activity.

The quest for sustainable and clean energy sources has led to significant research into photocatalytic water splitting, a process that converts solar energy into hydrogen fuel. This study demonstrates constructing a high-performance CdTe/CN van der Waals heterojunction for solar-driven water splitting hydrogen evolution. The proposed CdTe/CN heterojunction, investigated using first-principles calculations, integrates favorable structural stability and features a direct bandgap of 1.

Decoupling Transport of Salt Ions and Water in Hierarchically Structured Hydrogel for High Salinity Desalination.

Global water scarcity demands next-generation desalination technologies that transcend the limitations of energy-intensive processes and salt accumulation. Herein, a groundbreaking interfacial solar steam generation system capable of simultaneous hypersaline desalination and ambient energy harvesting is introduced. Through hierarchical hydrogel architecture incorporating a central vertical channel and radial channels with gradient apertures, the design effectively decouples salt transport and water evaporation: solar-driven fluid convection directs water outward for evaporation, while inward salt migration prevents surface crystallization and redistributes excess heat.

Engineering Aging: Approaches to Model and Deconstruct Biological Complexity.

The disparity between the global increase in life expectancy and the steady decline in health outcomes with age has been a major driver for developing new ways to research aging. Although this current tools for studying aging outside of the human body-such as animal models and cells in a dish-have improved this fundamental understanding of the markers and key mechanisms underlying this process, several limitations remain. Animal models are poor biological representations of humans and have a weak track record of translating pre-clinical results into successful clinical applications.

Ultrasound Active Piezoelectric Nanostimulators for Long-Acting Wireless Deep Brain Electric Stimulation to Inhibit Epileptic Seizures.

Electrical deep brain stimulation is effective for epilepsy suppression, but will lead to neural tissue damage and inflammation due to implantation of electrodes and a pulse generator. Transcranial magnetic and transcranial ultrasound stimulation cannot directly generate effective electrical signals in deep brain regions. Here, the use of piezoelectric nanoparticles is proposed as wireless nanostimulators for deep brain electrical stimulation and minimally invasive suppression of epilepsy.

Estrous Cycle Impacts Fear Extinction and Relapse in Female Adolescent Rats.

Adolescent male rodents and humans exhibit impairments in extinguishing learned fear. Here, we investigated whether female adolescent rats exhibit such impairments and if extinction is affected by the estrous cycle as in adults. Following fear conditioning to a discrete cue, female adolescent Sprague Dawley rats were extinguished either around the onset of puberty, when estrous cycling begins, or across different stages of the estrous cycle.

Urgent Care Centre Eligible Presentations in a Remote Emergency Department.

Objective: This study aimed to identify presentations to the Alice Springs Emergency Department that could be managed in an Urgent Care Centre (UCC).

Methods: We reviewed 1 year of ED presentation data at Alice Springs Hospital (ASH) from August 2022 to August 2023 and used a sequence of exclusion criteria to identify patients most likely to be eligible for UCC management.

Results: Our model indicated that 35.

I'm Not Like the Others: Atypical Research Subjects in JEAB Publications.

Comparative psychologists have been criticized for using a limited number of species in drawing general conclusions about broad behavioral processes. There are numerous examples, however, of the inclusion by behavior analysts of atypical subjects in their research. To examine the frequency and diversity in subject species used in the experimental analysis of behavior (EAB), JEAB publications between 1958 and 2023 were reviewed for their use of subjects other than pigeons, rats, humans, and nonhuman primates.