Factors affecting career-related decisions within the contemporary pharmacy workforce in Australia.

Introduction: Pharmacists are essential to healthcare delivery in Australia, making effective workforce planning critical to ensure equitable health outcomes. This study explores factors influencing the career decisions of Australian pharmacists from diverse demographic and geographical backgrounds with implications for recruitment, retention and policy strategies to address workforce shortages.

Method: We conducted semi-structured interviews between November 2022-February 2024.

Australian pharmacists' experiences and perspectives in implementing a chronic kidney disease screening service in community pharmacies: A qualitative study.

Background: The emerging role of pharmacists in chronic kidney disease (CKD) care prompted the pharmacy-led screening and quality use of medicines in CKD trial (QUM-CKD), a pharmacy-led screening initiative to detect previously undiagnosed CKD and improve medication safety.Objective: To explore pharmacists' experiences and perspectives on the implementation of the QUM-CKD trial in Australian community pharmacies.

Methods: A descriptive phenomenological qualitative approach was employed, involving in-depth, semi-structured telephone interviews with thirteen metropolitan and rural community pharmacists in the trial.

Expanding Uranium Oxide Hydrate Frameworks toward Early Lanthanides: Cases for Pr(III) and Nd(III) Ions.

We report the hydrothermal syntheses and structural and spectroscopic characterization of two new uranium oxide hydrate frameworks (UOHFs) with either Pr or Nd ions, Pr(HO)[(UO)UO(OH)] () or Nd(HO)[(UO)UO(OH)] (). Both UOHFs crystallize in the orthorhombic 222 space group and display needle crystal morphologies. Their crystal structures are composed of β-UO-type layers connected by double uranium polyhedra to form the frameworks, with disordered Pr/Nd ions within the framework channels, as revealed by synchrotron single-crystal XRD.

Tuna Oil-Enriched Toddler Formula Enhances DHA Status in Indonesian Toddlers.

Docosahexaenoic acid (DHA) is essential for brain and cognitive development in toddlers; however, global intakes often fall below recommended levels. This study evaluated the bioavailability of DHA from commercial toddler formulas fortified with either microencapsulated high-DHA fish oil powder or high-DHA fish oil. A double-blind, randomized controlled trial was conducted in 120 healthy Indonesian toddlers aged 2-3 years.

Glycemic and Insulinemic Index Values of Apple Puree.

A low glycemic index is known to have numerous health benefits, especially in the prevention of metabolic diseases as type 2 diabetes. The glycemic response following specific foods consumption has been reported in numerous tables, but few of them include data on apple-based fruit desserts as puree, while they represent a major food consumed by children and adolescents. The aim of this study was to determine the glycemic and insulinemic response of two different apple purees from France and the United States, made from different raw materials and with different processes.

Physiotherapists' delivery of a mobile health physical activity intervention for people post-stroke and transient ischemic attack: Insights from a feasibility study.

Background And Purpose: Mobile health (mHealth) offers a promising platform for promoting physical activity (PA) in individuals post-stroke or transient ischemic attack (TIA). However, the extent to which key intervention components of PA promotion can be adapted to a digital format remains unclear. This study examines the fidelity of delivering supervised physical exercise and support for individualized PA goals in a 6-month mHealth intervention.

Assembly-free typing of Nanopore and Illumina data through proximity scoring with KMA.

Advances in Oxford Nanopore Technologies (ONT) with the introduction of the r10.4.1 flow cell have reduced the sequencing error rates to <1%.

A high-resolution meiotic crossover map from single-nucleus ATAC-seq reveals insights into the recombination landscape in mammals.

Meiotic crossovers promote correct chromosome segregation and the shuffling of genetic diversity. However, the measurement of crossovers remains challenging, impeding our ability to decipher the molecular mechanisms that are necessary for their formation and regulation. Here we demonstrate a novel repurposing of the single-nucleus Assay for Transposase Accessible Chromatin with sequencing (snATAC-seq) as a simple and high-throughput method to identify and characterize meiotic crossovers from haploid testis nuclei.

Explainable Machine Learning Assists in Revealing Associations Between Polysomnographic Biomarkers and Incident Type 2 Diabetes in Men.

Introduction: Type 2 diabetes (T2D) shows bidirectional relationships with polysomnographic measures. However, no studies have searched systematically for novel polysomnographic biomarkers of T2D. We therefore investigated if state-of-the-art explainable machine learning (ML) models could identify new polysomnographic biomarkers predictive of incident T2D.

Magnesium Bisglycinate Supplementation in Healthy Adults Reporting Poor Sleep: A Randomized, Placebo-Controlled Trial.

Purpose: To assess the effects of magnesium bisglycinate supplementation on insomnia symptoms in healthy adults reporting poor sleep quality.

Patients And Methods: This randomized, double-blind, placebo-controlled trial enrolled 155 adults aged 18-65 years with self-reported poor sleep quality. Participants were randomly assigned to either magnesium bisglycinate supplementation (250 mg elemental magnesium, daily) or placebo capsules.

An iPSC-derived neuronal model reveals manganese's role in neuronal endocytosis, calcium flux and mitochondrial bioenergetics.

Manganese (Mn) is an essential trace metal required for normal biological function, yet it also poses neurotoxic risks when dysregulated. Maintaining proper intracellular and extracellular Mn levels is critical, as Mn imbalance has been implicated in a spectrum of human diseases-including inherited Mn transport disorders, acquired manganism, and more prevalent neurodegenerative diseases such as Parkinson's and Alzheimer's disease. Despite these associations, the cellular mechanisms driving Mn-induced neuropathology remain poorly understood.

OpenEMMU: A versatile, open-source EdU multiplexing methodology for studying DNA replication and cell cycle dynamics.

5-Ethynyl-2'-deoxyuridine (EdU) has revolutionized DNA replication and cell cycle analyses through fast, efficient click chemistry detection. However, commercial EdU kits suffer from high costs, proprietary formulations, limited antibody multiplexing capabilities, and difficulties with larger biological specimens. Here, we present OpenEMMU (Open-source EdU Multiplexing Methodology for Understanding DNA replication dynamics), an optimized, affordable, and user-friendly click chemistry platform utilizing off-the-shelf reagents.

The role of GLP-1 receptor agonists in IBD-related surgery and IBD-related complications of inflammatory bowel disease among patients with metabolic comorbidities: a systematic review and meta-analysis.

Background: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are widely used for type 2 diabetes and obesity, and emerging evidence suggests potential immunomodulatory effects. However, few studies have evaluated their role in inflammatory bowel disease (IBD), and no comprehensive clinical trials exist. This meta-analysis aimed to assess the association between GLP-1RA use and IBD-related surgeries and complications.

Extraintestinal Symptoms of Pain Are Common in Patients With Eosinophilic Gastrointestinal Diseases.

Background And Aims: Extraintestinal symptoms are well-documented in systemic, inflammation-predominant conditions. Less is understood about extragastrointestinal symptoms among individuals with eosinophilic esophagitis (EoE) and non-EoE eosinophilic gastrointestinal diseases (EGIDs). We aimed to describe the differences in the frequency of patient-reported joint or leg pain and headache for EoE and non-EoE EGIDs individuals.

Wild-type and engineered adeno-associated viral vectors produce comparable opsin expression and light-evoked responses in rat skeletal muscle.

Optogenetics offers a minimally invasive, low-fatigue, and temporally precise alternative to electrical stimulation for skeletal muscle control. After opsin expression in muscle cells, contraction can be stimulated with light. Obstructive sleep apnea, characterized by repeated airway collapse during sleep, suits this approach, as upper airway muscles are readily accessible via the oral cavity, and require stimulation synchronized to respiration.

Navigating a Decade of Integrated Care Research in the International Journal of Integrated Care: How Far Have We Come?

Introduction: The scope of integrated care has evolved and broadened the past decades from specialist pathways to incorporate a more holistic approach. To identify such trends in evidence and knowledge, we analysed published papers in the International Journal of Integrated Care over a 10-year period.

Methods: From an initial set of 5.

Functionalized Nanoporous Biocarbon with High Specific Surface Area Derived from Waste Hardwood Chips for CO Capture and Supercapacitors.

Waste biomass has aroused increasing interest in the production of low-cost materials for CO adsorption and supercapacitors. One of the primary facets in this regard is to develop nanoporous carbons with controlled porosity and high surface area. Herein, waste wood chips are used to synthesize nanoporous biocarbons via a solid-state KOH-based chemical activation.

Development and initial evaluation of an ultra-brief digital treatment for perinatal depression and anxiety symptoms.

Psychological treatments for perinatal depression and anxiety are effective when delivered in-person or remotely. However, new and expectant mothers face considerable barriers to receiving mental health care, especially on an ongoing basis or when delivered in-person. Very brief digital treatments may be able to support women during this time using less time than existing treatments.

Greater Personal Health Agency Is Associated With Greater Patient Receptiveness to Mindset Exercises.

Among 203 patients presenting for musculoskeletal specialty care between November 2023 and January 2024, we measured the relationship of openness to mindset exercises such as cognitive behavioral therapy (training the mind to default to healthier thoughts and feelings about bodily sensations) with levels of personal health agency accounting for other personal factors. Factors associated with greater openness to mindset exercises in linear regression included greater personal health agency (RC = 0.17), younger age (RC = -0.

Dwarf Mongooses Lose Body Mass in Hot Weather due to Limited Behavioural Plasticity.

High temperatures associated with climate change can have adverse effects on wildlife, but behavioural plasticity may buffer such negative effects. Using long-term data from wild dwarf mongooses (), we investigated the impact of high temperatures on daily activity patterns, movement and body mass. On hot days (≥ 35°C) compared with matched cooler ones (≤ 33°C), groups emerged from their overnight sleeping burrow and commenced foraging earlier in the morning and arrived at their overnight sleeping burrow later in the evening.

Gender differences in the prevalence and correlates of COVID-19 fear among mental health professionals: a network perspective based on a national survey in China.

Background: Gender differences in COVID-19-related fear among mental health professionals (MHPs) have been inadequately studied. This study compared the gender differences in prevalence, correlates and network structure of COVID-19 fear among MHPs in China in the post-pandemic era.

Methods: A nationwide cross-sectional study was conducted between January 22 and February 10, 2023.

The non-linear association of physical fatigue with depression and anxiety among mental health professionals who recovered from COVID-19 infection: a national survey in China.

Background: The COVID-19 pandemic took a toll on everyone's health and mental health professionals were no exception. This study examined the trajectory of the relationship between levels of physical fatigue and each of depression and anxiety in mental health professionals (MHPs) recovering from COVID-19.

Methods: A national survey of 9,858 MHPs who had recovered from COVID-19 was conducted between January and February 2023.

High-Pressure Injection Injury Debridement With the Versajet II Hydrosurgery System: Case Study and Literature Review.

High-pressure injection injuries to the hand are infrequent but potentially catastrophic injuries that have the potential for amputation or severe functional deficits. This is a case report on the management of a 28-year-old machinery operator who sustained a high-pressure grease gun injury to his dominant hand and underwent surgical debridement with a novel hydrosurgery technique. He had no complications and achieved a good functional outcome with a Disabilities of the Arm, Shoulder and Hand score of 1.

Trends and differences in the rates of autopsy in the United States, 2003 to 2020: A nationwide analysis.

Background: Autopsy, the gold standard for determining the cause of death, is declining globally. Significant differences exist between clinical diagnoses and those revealed at autopsy. Evidence of disparities in autopsy rates between different patient groups has previously been reported.