Data-Driven Additive Discovery with HOMO-Descriptor Enables Durable Aqueous Zinc Batteries via Interfacial Kinetics Engineering.

Dendritic growth and parasitic reactions severely hinder aqueous Zn-ion batteries due to interfacial instability and uncontrolled charge transfer. Here, a machine learning-accelerated strategy for rational additive screening, establishing a predictive framework that links the highest occupied molecular orbital (HOMO) energy level to the adsorption and reduction behavior of Zn, is reported. An interpretable machine learning model (Adaptive Boosting), trained on a curated molecular dataset, achieves high accuracy (Mean Squared Error = 0.

Design, synthesis, and anticancer evaluation of new Quinazoline hybrids: DNA intercalation, topoisomerase IIα inhibition, and in silico studies.

DNA intercalators and topoisomerases are regarded as prominent targets for cancer treatment. Herein, a novel series of quinazoline hybrids 5-14 were designed and synthesized as potent DNA intercalators and topoisomerase II inhibitors for cancer treatment. Their antiproliferative activity was evaluated in vitro across the NCI-60 human tumor cell lines panel.

Decades of land use change and its impact on air quality in Egypt's Middle Nile Delta observed from space.

Air pollution has become one of the most pressing environmental challenges globally, with significant consequences for public health and ecosystems. Recently, Gharbia Governorate has undergone remarkable changes in land use/land cover (LULC), leading to a variety of environmental impacts. These transformations have raised concerns about their potential influence on air quality, making it crucial to investigate how shifts in LULC are affecting pollution levels in the region.

Domestic violence and outcome of pregnancy among pregnant females at Alzahraa University Hospital.

Violence against women is a distressing issue, particularly when the victim is pregnant. However, the pregnancy outcomes of many pregnant women who were subjected to violence are complicated. The present research aimed to evaluate the prevalence of domestic violence against pregnant women and its consequences on the outcome of pregnancy.

Unlocking Therapeutic Potential of Novel Thieno-Oxazepine Hybrids as Multi-Target Inhibitors of AChE/BChE and Evaluation Against Alzheimer's Disease: In Vivo, In Vitro, Histopathological, and Docking Studies.

Alzheimer's disease (AD) is largely linked with oxidative stress, the accumulation of amyloid- plaques, and hyperphosphorylated -protein aggregation. Alterations in dopaminergic and serotonergic neurotransmission have also been implicated in various AD-related symptoms. : To explore new therapeutic agents, a series of bicyclic and tricyclic thieno-oxazepine derivatives were synthesized as potential acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors.

Genomic Characterization of Marine Strain SC-M1C: Potential Genetic Adaptations and Ecological Role.

() is a coagulase-negative species primarily associated with the degradation of organic matter, contributing to nutrient cycling in natural environments. This species has been mainly studied in clinical and terrestrial contexts, with no previous reports of its presence in marine environments. In this study, we report the first isolation of from a marine habitat.

Development and Biochemical Characterization of Quorum Quenching Enzyme from Deep-Sea DH82.

Quorum quenching (QQ) is of interest for potential application as a sustainable strategy for bacterial disease control via communication interruption. The QQ enzyme can be used as a good alternative antagonist to combat antibiotic abuse and bacterial resistance. Here, genomic DNA sequencing was performed on -acyl homoserine lactonase from the deep-sea strain DH82 with Cluster of Orthologous Groups of proteins (COGs) annotation.

Demographic Parameters and Life History Traits of (Oudemans) (Acari: Phytoseiidae) Influenced by Different Temperatures and Two Types of Food.

Studying the nutritional ecology of (Oudemans) at different temperatures is a fundamental tool for improving mass production for use in biological control of pest mites. The current research studied the impact of both food types and temperatures on the life history and demographic parameters of the predator mite . Mite cultures in the laboratory were developed using Koch, and was collected from field plants.

The Role of Inflammatory Biomarkers in Predicting Postoperative Fever Following Flexible Ureteroscopy.

: Flexible ureteroscopic surgery is a common minimally invasive procedure utilized for the management of various urological conditions. While effective, postoperative complications such as fever can occur, necessitating the identification of reliable biomarkers for early detection and management. In this study, we specifically evaluated the predictive performance of three preoperative hematologic indices: the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII).

Efficacy and Safety of Esaxerenone for Essential Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Esaxerenone, a novel non-steroidal mineralocorticoid receptor antagonist, has shown promising results in the treatment of essential hypertension (HTN). This study aims to comprehensively analyze the effectiveness of esaxerenone to control BP in patients with essential HTN. A systematic search was performed on PubMed, Scopus, Web of Science (WOS), and Cochrane Library from inception until January 2025 for randomized controlled trials (RCTs) comparing esaxerenone with standard HTN usual care.

Methylene Blue Mitigates Doxorubicin-Induced Cardiotoxicity via KEAP1/NRF2/GPX-4/Caspase3 Modulation.

Doxorubicin (Dox) is a potent anthracycline antitumor drug whose clinical utility is significantly restricted by its dose-dependent, cumulative cardiotoxicity, driven by increased oxidative stress, impaired antioxidant defenses, and apoptosis-mediated cardiomyocyte loss. Methylene blue (MB), a phenothiazine derivative with well-documented redox-modulating properties, is being explored as a viable cardioprotective agent due to its antioxidant and anti-apoptotic effects. This study evaluated the protective role of MB against Dox-induced cardiotoxicity in rats by examining its impact on oxidative stress markers (Kelch-like ECH-associated protein 1; KEAP1, nuclear factor erythroid 2-related factor 2; NRF2, Glutathione peroxidase 4; GPX-4, 8-hydroxy-2'-deoxyguanosine; 8-OHdG), neurohormonal indicators (noradrenaline), cardiac injury biomarkers (troponin I), and apoptotic mediators (p53, Caspase-3).

Parental Knowledge, Attitude and Practices Toward Cariogenic Potential of Pediatric Oral Medications.

: Sugar added to pediatric oral medications may increase the risk of dental caries and erosion. Parental awareness and practices play a crucial role in minimizing the oral health risks associated with such medications. Therefore, the aim was to assess parents' knowledge, attitudes, and practices regarding the cariogenic potential of pediatric oral medications in the Kingdom of Saudi Arabia.

Effect of connector size and configuration on the fracture resistance of a long-span implant-supported monolithic zirconia fixed partial denture (An in vitro Study).

Background: Monolithic zirconia fixed partial dentures (FPDs) have gained popularity due to their high strength, biocompatibility and reduced veneer chipping compared to bilayered restorations. However, the connector region remains a critical point of mechanical failure, especially in long span implant supported FPDs subjected to high masticatory forces. The purpose of this in vitro study was to compare the fracture resistance of implant-supported Y-TZP (yttria-stabilized tetragonal zirconia polycrystal) fixed partial dentures (FPDs) with two connector sizes (9 mm² and 12 mm²) and two connector cross-sectional shapes (oval and circular).

Proteus mirabilis in ICU Patients: Prevalence, Risk Factors, and Future Expectations of Bloodstream Infections.

Background is an emerging but under-recognized cause of bloodstream infections (BSIs) in intensive care unit (ICU) settings, where invasive procedures and immunocompromised states increase vulnerability. Despite its clinical importance, the epidemiology and risk factors associated with BSIs remain poorly understood, especially in low- and middle-income countries. Gap Most existing studies generalize Gram-negative pathogens without isolating the specific impact of in ICU populations.

Non-alcoholic steatohepatitis incidence in patients with psoriasis vulgaris.

Background And Aims: Non-alcoholic steatohepatitis (NASH) is a severe form of non-alcoholic fatty liver disease (NAFLD), characterized by hepatic inflammation and damage due to fat accumulation. Psoriasis patients show higher NASH incidence due to overlapping risk factors like obesity and insulin resistance. The study aimed to determine the incidence of non-alcoholic steatohepatitis in patients with psoriasis vulgaris.

miRNA-mediated resistance mechanisms in prostate cancer: implications for targeted therapy and metastatic progression.

Prostate cancer (PCa) remains a leading cause of cancer-related morbidity and mortality in men, with progression to castration-resistant and metastatic disease driven largely by therapeutic resistance. While numerous reviews have cataloged dysregulated microRNAs (miRNAs) in prostate cancer, this review offers a novel, mechanism-centered synthesis focused specifically on miRNA-mediated resistance pathways across standard treatment modalities-including androgen deprivation therapy (ADT), enzalutamide, docetaxel, and radiotherapy. Rather than providing a broad survey of miRNA functions, we prioritize miRNAs with robust experimental validation in PCa (e.

Discovery of new thiadiazole-based VEGFR-2 inhibitors: design, synthesis, cytotoxicity, and apoptosis induction.

Background: Vascular endothelial growth factor receptor-2 (VEGFR-2) is a validated target in cancer therapy. However, approved inhibitors like sorafenib are often limited by off-target toxicity and resistance. This study aimed to develop novel thiadiazole-based VEGFR-2 inhibitors with improved selectivity and safer profiles.

The Involvement of RIPK-3/Caspase-8 Inhibition and Nrf2/HO-1 Upregulation in the Protective Effect of Umbelliferone Against Chlorpyrifos-Induced Pulmonary Toxicity.

Chlorpyrifos (CPF) is a pesticide commonly used for pest management. Regretfully, there is evidence that pesticides can cause pulmonary toxicity. The phytochemical umbelliferone (UMB) possesses anti-inflammatory and antioxidant bioactivities.

Impact of telemedicine on mortality, hospital admissions, and length of stay in pediatric emergencies: a systematic review and meta-analysis.

Background: Pediatric emergencies pose significant challenges in healthcare. Telemedicine offers a promising solution by enabling remote assessments, improving specialist access, reducing unnecessary ER visits and admissions, optimizing resources, and enhancing patient satisfaction. This systematic review and meta-analysis uniquely aimed to quantify the effect of telemedicine on key outcomes in pediatric emergency and post-emergency care.

Impact of veriflex and ICL on corneal biomechanics and endothelial cell density.

To evaluate endothelial cell density (ECD) and corneal biomechanical changes following implantation of Veriflex and Implantable Collamer Lens (ICL) phakic intraocular lenses (pIOLs) over a 12-month period. Sixty patients (117 eyes) were included in this prospective comparative study. 58 eyes underwent implantation with the Veriflex lens (Group I), while 59 eyes received the ICL (Group II).

Bioprotective potential of biosynthesized copper oxide nanoparticles and copper phosphite against Alternaria-solani-induced leaf spot in pepper plants.

Alternaria solani leaf spot disease (ASLS) poses a serious threat to global crop production, including peppers, resulting in notable economic losses. Bio-nanotechnology offers promising solutions for combating plant pathogens by promoting plant defenses and inhibiting pathogen growth. This study explores the effectiveness of copper oxide nanoparticles (CNPs) and copper phosphite (MAXIFOS CU®) in controlling A.

Eco-Friendly Simultaneous Quantification of Domperidone and Safinamide by Spectral Resolution using deconvoluted Synchronous Fluorescence: Application to Spiked Human Plasma.

A novel, eco-friendly deconvoluted synchronous spectrofluorimetric method has been developed and validated for the simultaneous determination of domperidone (DOM) and safinamide (SAF), a potential combination used to address Parkinson's disease-associated gastrointestinal dysfunction. Their combined administration necessitates a reliable analytical method for therapeutic monitoring and formulation quality control. Traditional spectrofluorimetric techniques fail to resolve the significant spectral overlap between these two compounds.

Effect of Thermal Ageing on Flexural Strength and Microhardness of Novel High-Performance Polymer (Nanoksa G-Plus) in Comparison to a Widely Used Bio-HPP/PEEK.

The dental industry is continuously developing high-performance polymer (HPP) materials with different qualities for denture frameworks. The aim of this in vitro study was to assess how thermal ageing (TA) affects the flexural strength (FS) and microhardness of two different HPP materials: Nanoksa G-plus and Bio-HPP/PEEK. The TA process was carried out for 5000 cycles at 5 °C and 55 °C in distilled water.