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Chitosan is a modified natural biopolymer obtained through the deacetylation of chitin, which is primarily found in the shells of crustaceans. Chitosan has recently attracted a lot of attention due to its possible use in the chemical, medical and food and industries. Due to its distinct biological activities and functional properties, its applications in the food industry are especially noteworthy. Its antimicrobial properties and ability to form films makes the biopolymer a promising natural food preservative and coating material. Chitosan exhibits antimicrobial activity against a broad spectrum of foodborne microbes including fungi, yeast, both gram-negative and gram-positive bacteria. The antimicrobial ability, along with its film-forming properties have made chitosan a leading polymer for the development of active packaging that can prevent microbial growth and enhance food safety. In terms of optical characteristics, pure chitosan films are highly transparent in the visible light range, demonstrating high transmittance values. This feature is crucial for the consumer acceptance of the films. Moreover, chitosan-based films show excellent UV absorption, which helps protect food from lipid oxidation caused by UV radiation. The qualities, modifications and applications of chitosan in improving the shelf life and quality of a variety of foods, including seafood, poultry, vegetables, juice, rice cake, soyabean sprout, mayonnaise and etcetera are considered in this paper.
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http://dx.doi.org/10.1016/j.carres.2025.109667 | DOI Listing |
Fundam Clin Pharmacol
October 2025
Postgraduate Program in Pharmaceutical Science, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil.
This review highlights the integration of drug repurposing and nanotechnology-driven delivery strategies as innovative approaches to enhance the antifungal activity of statins against mucosal candidiasis, providing a framework for future translational research and clinical application. The rising prevalence of antifungal resistance and virulence factors of Candida albicans underscore the limitations of current therapies. Statins, commonly used as lipid-lowering agents, have emerged as attractive repurposed drug candidates due to their ability to interfere with fungal ergosterol biosynthesis and Ras-mediated signaling pathways.
View Article and Find Full Text PDFInt J Biol Macromol
September 2025
Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals & College of Pharmaceutical Science, Zhejiang University of Technology, 310014, Hangzhou, China. Electronic address:
Tumor surgery often leads to tumor residue, tissue defects, and drug-resistant bacterial infections, resulting in high recurrence rates and chronic wounds. In this study, an injectable hydrogel was synthesized using glycidyl trimethyl ammonium chloride-chitosan (GCh) and formylbenzoic acid-modified chrysomycin A (CA)-loaded F127 micelles (F127FA-CA). The formation of the hydrogel is achieved through Schiff base conjugation, which occurs between the amino groups present in GCh and the aldehyde groups located on the micelle surfaces.
View Article and Find Full Text PDFJ Biomater Sci Polym Ed
September 2025
Department of Bioengineering, Faculty of Chemical and Metallurgical Engineering, Yildiz Technical University, Turkey.
Biodegradable biosensors represent a transformative advancement in sustainable sensing technology, offering an environmentally friendly and biocompatible alternative to traditional sensors. This review examines recent advancements, material innovations, degradation mechanisms, and application areas of biodegradable biosensors within the biomedical and environmental sectors. Natural and synthetic biodegradable polymers, such as chitosan, silk fibroin, alginate, PLA, PLGA, and PVA, are assessed for their functional contributions to sensing platforms.
View Article and Find Full Text PDFBiomater Biosyst
September 2025
ENT and Head and Neck Research Center and Department, The Five Senses Health Institute, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Introduction: The airway mucosa plays a crucial role in protection and various physiological functions. Current methods for restoring airway mucosa, such as myocutaneous flaps or split skin grafts, create a stratified squamous layer that lacks the cilia and mucus-secreting glands of the native columnar-lined airway. This study examines the application of various injectable biopolymers as active molecules for a potential approach to regenerating laryngeal epithelial tissue.
View Article and Find Full Text PDFCNS Neurol Disord Drug Targets
September 2025
College of Pharmacy, National University of Science and Technology, Muscat, Oman.
Neurological disorders are complex conditions characterized by impairment of the nervous system, affecting motor, cognitive, and sensory functions. Current treatments meet substantial obstacles, primarily due to the difficulty of transporting drugs across the blood-brain barrier and ineffective therapy for nerve regeneration. Emerging technologies, such as electrospinning, offer innovative solutions to overcome these challenges.
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