Recent advances in biodegradable biosensors for biomedical and environmental applications.

J Biomater Sci Polym Ed

Department of Bioengineering, Faculty of Chemical and Metallurgical Engineering, Yildiz Technical University, Turkey.

Published: September 2025


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Biodegradable biosensors represent a transformative advancement in sustainable sensing technology, offering an environmentally friendly and biocompatible alternative to traditional sensors. This review examines recent advancements, material innovations, degradation mechanisms, and application areas of biodegradable biosensors within the biomedical and environmental sectors. Natural and synthetic biodegradable polymers, such as chitosan, silk fibroin, alginate, PLA, PLGA, and PVA, are assessed for their functional contributions to sensing platforms. Applications, ranging from implantable cardiovascular and neural sensors to soil nutrient monitors and gas detectors, are detailed with corresponding performance data. Although challenges related to signal stability, integration, and long-term operation persist, future research emphasizes multifunctionality, wireless communication, energy autonomy, and AI-driven diagnostics. This review highlights the potential of biodegradable biosensors to transform health monitoring, environmental assessment, and personalized medicine by aligning technological functionality with principles of sustainability.

Download full-text PDF

Source
http://dx.doi.org/10.1080/09205063.2025.2554132DOI Listing

Publication Analysis

Top Keywords

biodegradable biosensors
16
biosensors biomedical
8
biomedical environmental
8
advances biodegradable
4
biosensors
4
environmental applications
4
biodegradable
4
applications biodegradable
4
biosensors represent
4
represent transformative
4

Similar Publications

Visualizing intracellular glycine with two-dye and single-dye ratiometric RNA-based sensors.

Nucleic Acids Res

September 2025

Department of Chemistry and Henry Eyring Center for Cell and Genome Science, University of Utah, Salt Lake City, UT 84112, United States.

Glycine is an important metabolite and cell signal in diverse organisms, yet tools to visualize intracellular glycine dynamics have not been developed. In this study, diverse and bright RNA-based glycine biosensors were developed by fusing the architecturally complex glycine riboswitch with Broccoli class fluorogenic aptamers. The brightest sensor with the highest activation, glyS, and its two-dye ratiometric counterpart, Pepper-glyS, allowed for visualization of a drug-induced accumulation of endogenous glycine in live Escherichia colicells.

View Article and Find Full Text PDF

Recent advances in biodegradable biosensors for biomedical and environmental applications.

J Biomater Sci Polym Ed

September 2025

Department of Bioengineering, Faculty of Chemical and Metallurgical Engineering, Yildiz Technical University, Turkey.

Biodegradable biosensors represent a transformative advancement in sustainable sensing technology, offering an environmentally friendly and biocompatible alternative to traditional sensors. This review examines recent advancements, material innovations, degradation mechanisms, and application areas of biodegradable biosensors within the biomedical and environmental sectors. Natural and synthetic biodegradable polymers, such as chitosan, silk fibroin, alginate, PLA, PLGA, and PVA, are assessed for their functional contributions to sensing platforms.

View Article and Find Full Text PDF

Electroactive bacteria (EAB) hold great promise for the development of electrochemical biosensors given their unique ability to transfer electrons extracellularly via specialized pathways, a process termed extracellular electron transfer (EET). Ongoing research aims to overcome current limitations and fully harness the potential of EABs for high-performance biosensing applications. Herein, we report the fabrication of an electrochemical microsensor based on biomineralized electroactive bacteria, specifically MR-1.

View Article and Find Full Text PDF

A sensitive electrochemical glucose biosensor using ZrO₂@CNTs nanocomposite was developed for real-time metabolism monitoring for athletes. The nanocomposite was prepared by a simple ultrasound-assisted technique, and the glucose oxidase (GOx) was covalently immobilized to improve the biorecognition ability. CNTs treated with acid served as a highly conductive framework, and ZrO₂ nanoparticles can provide structural stability and catalytic performance, thus showing synergistic enhancement of electron transfer kinetics and enzyme loading capacity.

View Article and Find Full Text PDF

Agonist-induced interaction of G protein-coupled receptors (GPCRs) with β-arrestins (βarrs) is a critical mechanism that regulates the spatiotemporal pattern of receptor localization and signaling. While the underlying mechanism governing GPCR-βarr interaction is primarily conserved and involves receptor activation and phosphorylation, there are several examples of receptor-specific fine-tuning of βarr-mediated functional outcomes. Considering the key contribution of conformational plasticity of βarrs in driving receptor-specific functional responses, it is important to develop novel sensors capable of reporting distinct βarr conformations in cellular context.

View Article and Find Full Text PDF