Three undescribed Schinortriterpenoids from Schisandra chinensis and their neuroprotective effects.

Fitoterapia

Heilongjiang University of Chinese Medicine, Harbin 150040, China; Traditional Chinese Medicine Biological Genetics, Heilongjiang Province Double First-Class Construction Interdiscipline, Harbin 150040, China. Electronic address:

Published: August 2025


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Article Abstract

Three undescribed SNTs, schisaterpene SU (1-3), were isolated from the extract of Schisandra chinensis. Their structures were elucidated on the basis of HR-ESI-MS, NMR data and ECD calculation. All compounds were evaluated for their Neuroprotective activity induced by MPP in SH-SY5Y cells. Notably, compounds 1-3 exhibited significant neuroprotective activity, with EC values of 4.46 ± 0.30, 2.76 ± 0.09 and 3.99 ± 0.19 μM for SH-SY5Y cells.

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http://dx.doi.org/10.1016/j.fitote.2025.106853DOI Listing

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