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Three undescribed SNTs, schisaterpene SU (1-3), were isolated from the extract of Schisandra chinensis. Their structures were elucidated on the basis of HR-ESI-MS, NMR data and ECD calculation. All compounds were evaluated for their Neuroprotective activity induced by MPP in SH-SY5Y cells. Notably, compounds 1-3 exhibited significant neuroprotective activity, with EC values of 4.46 ± 0.30, 2.76 ± 0.09 and 3.99 ± 0.19 μM for SH-SY5Y cells.
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http://dx.doi.org/10.1016/j.fitote.2025.106853 | DOI Listing |
Phytochemistry
September 2025
State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, People's Republic of China; University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of Ch
Six undescribed sesquiterpene esters, euphoresulins A-F, along with fourteen known daucane analogues were isolated from the aerial parts of Euphorbia esula growing in Uzbekistan. Their structures were determined on the basis of extensive spectroscopic analyses, with absolute configurations established by comparison of experimental and calculated ECD data, in addition to single-crystal X-ray diffraction crystallography. Euphoresulins A-F (1-6) presented sesquiterpene ester types of daucane for euphoresulins A-D (1-4) and aromadendrane for euphoresulins E-F (5-6).
View Article and Find Full Text PDFPhytochemistry
September 2025
Équipe "Chimie des substances naturelles" BioCIS, CNRS, Université Paris-Saclay, 17, avenue des Sciences, 91400, Orsay, France. Electronic address:
Throughout the past decades, annonaceous plants have been of particular interest to the natural product community because of their therapeutic value and their richness in isoquinoline alkaloids. Taking advantage from our laboratory historical collection of these compounds, a MS/MS database of 322 isoquinolines and other metabolites from Annonaceae was implemented and named IQAMDB . The present report describes the dereplication of known alkaloids from stem barks of Greenwayodendron suaveolens (Engl.
View Article and Find Full Text PDFJ Nat Prod
September 2025
Laboratory of Medicinal Chemistry, Chulabhorn Research Institute, Bangkok 10210, Thailand.
Six previously undescribed alkaloids, including three dimeric aporphine alkaloids, mitrephorines A-C (-), two aristolactam-aporphine alkaloids, mitrephorines D and E ( and ), and one 4,5-dioxoaporphine alkaloid, 8-methoxycepharadione A (), accompanied by 13 previously identified compounds, were isolated from the bark of . Their structures were determined by the analysis of UV, IR, NMR, and HRMS, while absolute configurations were assigned by chiral HPLC, specific rotation values, and ECD spectral data. Known compounds (-) were identified by comparison with literature data.
View Article and Find Full Text PDFPLoS One
September 2025
UMR 152 PharmaDev, Université de Toulouse, UPS, IRD, Toulouse, France.
Artemisia annua L. (A. annua) is a medicinal herb that has been used for the last two millennia to treat various diseases.
View Article and Find Full Text PDFFitoterapia
August 2025
Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Health Science Center, Ningbo University, Ningbo 315211, Zhejiang, China; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 10019, China. Electronic address:
HSQC-TOCSY fingerprinting-guided fractionation led to the discovery of three undescribed pentaketide, hexaketide, and monocyclofarnesol-type sesquiterpenoid glycosides, namely acremols A-C (1-3), along with new scalemic pentaketides (+)-4 and (-)-4, designated as (+) and (-)-acremols D, from fungus Acremonium sp. NBUF233 associated with a mesophotic zone Ircinia sponge. The structural elucidation was achieved through comprehensive spectroscopic data analysis combined with chemical degradation.
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