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Article Abstract
Significance: Fetal oxygenation level is a critical indicator of fetal health throughout pregnancy and labor. Existing clinical devices predominantly employ invasive techniques, posing risks to both the fetus and the mother.
Aim: To address this concern, we present a noninvasive method for precise fetal oxygenation level monitoring using time-domain near-infrared spectroscopy (TD-NIRS).
Approach: Our method leverages the advantages of time-domain information for accurate separation of optical properties from two distinct layers, thereby enabling noninvasive detection of deep tissue oxygenation levels.
Results: We validate the proposed method via Monte Carlo simulations and develop a fiber-based TD-NIRS prototype system. In a two-layer tissue phantom experiment, the system accurately estimates the deep-layer absorption coefficient. We further demonstrate the ability of our prototype system to detect changes in the tissue oxygenation index (TOI) through experiments: (1) TOI measurements of the human forearm with a tissue phantom and (2) transabdominal fetal monitoring on a pregnant ewe.
Conclusions: The results suggest a significant potential for the use of TD-NIRS to noninvasively and safely monitor the fetal oxygenation level.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12374770 | PMC |
| http://dx.doi.org/10.1117/1.JBO.30.8.087001 | DOI Listing |
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