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Subwavelength plasmonic metasurfaces combined with multiple quantum wells (MQWs) heterostructures have recently demonstrated highly efficient nonlinear wave generation under low power input intensities. They can pave the way for developing highly efficient, compact, tunable and room temperature terahertz (THz) wave sources through the mixing and down-conversion of optical incident pumps. In this paper, we study and analyze the electrically controllable THz radiation of a nonlinear metasurface loaded with MQW through difference frequency generation (DFG) process. An analytical formulation procedure based on the effective nonlinear susceptibility model and free-space Green's function is proposed for derivation of generated THz wave radiation pattern. Also, we demonstrate phase and amplitude variation of intrinsic second-order nonlinear susceptibility coefficient of MQW by applying different bias voltages. Far-field directivity pattern of DFG radiation from the linear array configuration of plasmonic nonlinear metacells is obtained at 5.5 THz through the proposed analytical method and is verified by full-wave analysis. Using the proposed electrical tunability of MQW nonlinear susceptibility, THz beam steering of the nonlinear metasurface is demonstrated which is rotated from -20 to 20 degree through different bias voltages. Our work proposes an effective tool for rapid and accurate design and analysis of highly efficient THz electrically tunable MQW nonlinear metasurfaces for future applications in THz wireless communications, spectroscopy and quantum imaging.
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http://dx.doi.org/10.1364/OE.542462 | DOI Listing |
Ann Hematol
September 2025
Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510280, P. R. China.
Chimeric antigen receptor (CAR) therapies have demonstrated remarkable clinical efficacy in hematological malignancies, validating their therapeutic potential. However, challenges such as therapeutic resistance and limited accessibility hinder their broader application. To overcome these limitations, alternative CAR-based cell therapies, including CAR-Natural Killer (CAR-NK), CAR-macrophage (CAR-M), and CAR-dendritic cell (CAR-DC) therapies, have been proposed.
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State Key Laboratory of Chemical Engineering, Tianjin Key Laboratory of Membrane Science and Desalination Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, P. R. China.
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United States Department of Agriculture, Agricultural Research Service (USDA-ARS), Southeast Poultry Research Laboratories, US National Poultry Research Center, Athens, Georgia, USA.
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View Article and Find Full Text PDFJ Chem Theory Comput
September 2025
State Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, Department of Pharmaceutical Sciences, Institute of Chemical Process Systems Engineering, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, China.
Organometallic catalysis lies at the heart of numerous industrial processes that produce bulk and fine chemicals. The search for transition states and screening for organic ligands are vital in designing highly active organometallic catalysts with efficient reaction kinetics. However, identifying accurate transition states necessitates computationally intensive quantum chemistry calculations.
View Article and Find Full Text PDFJ Am Chem Soc
September 2025
Center of Drug Discovery, State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing 211198, China.
The advancement of bioorthogonal cleavage platforms has emerged as a critical frontier in chemical biology, offering precise molecular liberation through physiologically compatible activation mechanisms. Despite its significant potential, ensuring efficacy typically requires rapid reaction kinetics, high-efficiency payload release, and stable reactants; however, relevant reports remain sparse. Herein, we developed a strain-promoted alkyne-nitrone cycloaddition (SPANC)-based click-release chemistry through installation of a carbamate-linked release moiety at the propargyl position of cyclooctyne, triggering a spontaneous elimination following click cycloaddition to achieve efficient payload liberation.
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