Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/d41573-025-00102-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Light-emitting diode-derived blue light overexposure accelerates corneal endothelial cell aging by inducing abnormal ROS accumulation.
J Photochem Photobiol B
September 2025
The First Affiliated Hospital, Department of Ophthalmology, Hengyang Medical school, University of South China, Hengyang, Hunan 421001, China; Xiamen University Affiliated Xiamen Eye Center, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Fujian Engineering and Research Center
Blue light, defined as short-wavelength visible light ranging from 400 to 500 nm, is recognized for its high energy within the visible light spectrum. The prevalent use of light-emitting diodes (LEDs) has significantly increased exposure to blue light. Corneal endothelial cells (CECs) playing a crucial role in maintaining corneal transparency to get clear visual field.
View Article and Find Full Text PDFSIRT1 as a potential target for age-related eye diseases: mechanisms and therapeutic strategies.
Hum Cell
September 2025
Eye Hospital, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Age-related eye diseases (AREDs) are the leading cause of visual impairment in the elderly, affecting the structure of the anterior and posterior segments of the eye, significantly reducing the quality of life of patients, and even leading to irreversible blindness. Typical AREDs include age-related cataract (ARC), dry eye disease (DED), age-related macular degeneration (AMD), glaucoma, and diabetic retinopathy (DR), the global prevalence of which continues to rise, becoming a serious public health concern. SIRT1 is an NAD + dependent deacetylase, which plays an important physiological regulatory role in ocular tissues, mainly affecting gene expression and various cellular processes by regulating the acetylation status of substrate proteins.
View Article and Find Full Text PDFDeletion of the SHORT Syndrome Gene Prkce Results in Brain Atrophy and Cognitive and Motor Behavior Deficits in Mice.
Neurosci Bull
September 2025
Zhejiang Key Laboratory of Organ Development and Regeneration, College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, 311121, China.
The neurological manifestations of SHORT syndrome include intrauterine growth restriction, microcephaly, intellectual disability, hearing loss, and speech delay. SHORT syndrome is generally believed to be caused by PIK3R1 gene mutations and impaired PI3K-AKT activation. Recently, a clinical case report described a SHORT syndrome with a novel mutant in PRKCE gene encoding protein kinase Cε (PKCε).
View Article and Find Full Text PDFFabrication of ZIF/SiO hybrid particles to prepare cotton-based antibacterial and anti-biofilm composites with high durability.
Int J Biol Macromol
September 2025
School of textile science and Engineering, Wuhan Textile University, Wuhan, Hubei, 430000, China.
As living standards continue to rise, the demand for advanced cotton textiles that fulfill enhanced functional requirements has grown significantly. Therefore, the development of multifunctional antibacterial/hydrophobic cotton fabrics holds considerable practical value. In this study, a zeolitic imidazolate framework (ZIF-8) based hybrid material, ZIF/SiO-LDS (Long-chain derivative of silane), was synthesized via a co-precipitation method using silica, zinc nitrate hexahydrate, 3-aminopropyltriethoxysilane (KH-550), 2-methylimidazole and hexadecyltrimethylsilane (HDTMS).
View Article and Find Full Text PDFLongitudinal trends in HIV/AIDS adults aged over 60 years: A multidimensional decomposition with global and regional comparisons, 1990-2021.
J Infect Public Health
September 2025
Department of Laboratory Medicine, Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, Shanghai 200011, China. Electronic address:
Background: Antiretroviral therapy has extended the lifespan of HIV/ADIS. However, research and policies mainly target younger groups, leaving gaps in the care for aging people living with HIV (PLHIV).
Methods: Using data from the 2021 Global Burden of Disease Study, this research evaluated the global, regional, and national burdens of HIV/AIDS in adults aged 60 and above from 1990 to 2021.