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Article Abstract
Background And Purpose: Candidiasis is a prevalent fungal infection caused by various species of , especially, . The emergence of resistance to azole medications, which are frequently prescribed for the treatment of infections, presents a significant challenge in the management of these infections.
Materials And Methods: The present mini-review summarizes findings from a comprehensive search of articles published between 1999 and 2024, retrieved from Scopus, PubMed, and Web of Science. Studies were selected using specific keywords based on relevance to gene functions, azole resistance mechanisms, and biology.
Results: The gene has become crucial in regulating drug resistance in . This gene encodes a zinc (II)-Cys (6) transcription factor involved in the biosynthesis of sterols and contributes to resistance against azole antifungal drugs. When exposed to azoles, in enhances the expression of ergosterol biosynthesis genes, such as and . Increased expression of leads to reduced susceptibility to azoles by boosting the production of 14α-lanosterol demethylase, the primary target of these antifungal agents. Furthermore, regulates sterol uptake under anaerobic conditions and manages other adaptations to environmental changes, all of which contribute to azole resistance.
Conclusion: Gaining insight into how the gene contributes to azole resistance is essential for the development of effective strategies in the antifungal drug development process.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257043 | PMC |
| http://dx.doi.org/10.22034/cmm.2024.345248.1595 | DOI Listing |
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