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Article Abstract
Owing to their 4f electrons and high atomic numbers, lanthanide (Ln) elements impart lanthanide oxide (LnO) nanoparticles with excellent biomedical imaging properties. This study reports synthesis for three types of ultrasmall and monodisperse LnO nanoparticles (Ln = Eu, Gd, and Tb) via thermal decomposition in oleylamine at 280 °C, followed by ligand exchange with citric acid (CA) to produce water-dispersible, CA-grafted LnO nanoparticles with high colloidal stability. The resulting CA-grafted LnO nanoparticles had average diameters of approximately 2 nm. We characterized their physicochemical properties, including in vitro cytotoxicity, magnetic resonance imaging properties (i.e., water proton spin relaxivities), and X-ray imaging properties (i.e., X-ray attenuation).
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12196006 | PMC |
| http://dx.doi.org/10.3390/molecules30122519 | DOI Listing |
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