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http://dx.doi.org/10.1183/13993003.00553-2025 | DOI Listing |
Chem Commun (Camb)
September 2025
Department of Chemistry, College of Pharmacy, North China University of Science and Technology, Tang Shan, P. R. China.
Singlet oxygen (O) plays a crucial role in cancer chemotherapy and ROS biology, driving the need for highly specific probes to monitor its dynamics in real time. Herein, we developed the ratiometric fluorescent probe NAP-t-PY, utilizing a 2-pyridone recognition unit. The probe's 1-methyl-3-benzyl-2-pyridone moiety reacts specifically with O [4 + 2] cycloaddition, forming the endoperoxide NAP-t-PY-EP.
View Article and Find Full Text PDFProtein Cell
September 2025
Department of Human Cell Biology and Genetics, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China.
Breast cancer is a prevalent malignancy worldwide. The majority of breast cancers belong to the estrogen receptor (ER)-positive luminal subtype that can be effectively treated with antiestrogen therapies. However, a significant portion of such malignancies become hormone-refractory and incurable.
View Article and Find Full Text PDFBMB Rep
September 2025
Medical Innovation Technology Inc. (MEDINNO Inc.), Seoul 08517; Department of Anatomy & Cell Biology, Sungkyunkwan University School of Medicine, Suwon 16419; Stem Cell and Regenerative Medicine Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul 06351; Department of Health
The adult human neural stem cell (ahNSC)-conditioned medium (CM) contains various secreted factors that promote tissue repair and neuroprotection. This study aimed to identify the key secreted proteins in ahNSC-CM and investigate the role of tissue inhibitor of metalloproteinases-1 (TIMP-1) in wound healing, angiogenesis, and neuroprotection against oxygenglucose deprivation. Cytokine array and liquid chromatography- tandem mass spectrometry analysis of ahNSC-CM revealed that monocyte chemoattractant protein-1 (MCP-1) and TIMP-1 were highly abundant.
View Article and Find Full Text PDFJ Fish Biol
September 2025
School of Biodiversity, One Health & Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
The harvest of animals from the wild is a pervasive selective force, especially in fisheries, where harvesting often targets individuals with specific traits. While most research has focused on large-scale commercial or recreational fisheries, little attention has been paid to artisanal fisheries, particularly those targeting ornamental species. Furthermore, environmental factors such as temperature and oxygen levels influence the behaviour of fishes, such as boldness and sociability, but their role in the harvesting process remains poorly understood.
View Article and Find Full Text PDFFungal Biol
October 2025
Department of Pathogen Biology, School of Medicine, Nantong University, 226007, Nantong, Jiangsu, China. Electronic address:
Candida albicans employs apoptosis to maintain genomic stability under genotoxic stress, yet its regulatory mechanisms remain poorly defined. Here, we characterize the role of a putative pro-apoptotic factor Moh1 in C. albicans.
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