Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12053559PMC
http://dx.doi.org/10.1016/j.gendis.2024.101243DOI Listing

Publication Analysis

Top Keywords

establishment mouse
4
mouse model
4
model respiratory
4
respiratory mycoplasma
4
mycoplasma challenged
4
challenged intranasally
4
intranasally combined
4
combined intraperitoneally
4
intraperitoneally eliciting
4
eliciting chronic
4

Similar Publications

Non-obstructive azoospermia (NOA), characterized by impaired spermatogenesis and the complete absence of sperm in the ejaculate, represents one of the most severe forms of male infertility. Current diagnostic strategies rely on invasive procedures such as testicular sperm extraction, underscoring the urgent need for reliable, non-invasive alternatives. In the present study, we performed untargeted metabolomic profiling of human seminal plasma to identify biomarker panels capable of stratifying azoospermia subtypes through a stepwise approach.

View Article and Find Full Text PDF

Cefepime (FEP), a fourth-generation cephalosporin combined with tazobactam (TAZ), a β-lactamase inhibitor, is being developed by Wockhardt as a pharmacodynamically optimized fixed dose combination (FEP-2 g + TAZ-2 g) for the treatment of multidrug-resistant Gram-negative infections. To undertake an exposure-response analysis for establishing pharmacokinetic (PK)/pharmacodynamic (PD) targets, it is crucial to characterize the PK profile of compounds in surrogate compartments, such as plasma and lung, in clinically relevant animal infection models used to evaluate efficacy. In the current study, PKs of FEP and TAZ were assessed in plasma and in epithelial lining fluid (ELF) of neutropenic noninfected, lung-infected, and thigh-infected mice.

View Article and Find Full Text PDF

PACAP versus CGRP in migraine: From mouse models to clinical translation.

Cephalalgia

September 2025

Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, USA.

Migraine is a complex neurological disorder involving multiple neuropeptides that modulate nociceptive and sensory pathways. The most studied peptide is calcitonin gene-related peptide (CGRP), which is a well-established migraine trigger and therapeutic target. Recently, another peptide, pituitary adenylate cyclase-activating polypeptide (PACAP), has emerged as an alternative target for migraine therapeutics.

View Article and Find Full Text PDF

Complement C4b as a Key Mediator of Synaptic Loss and Cognitive Decline in Brain Aging.

Mol Ther

September 2025

Department of Health Management & Institute of Health Management, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 610054, China; Laboratory of Aging Research, School of Medicine, University of Electronic Science and Technology of China, Chengdu

Brain aging is a major risk factor for cognitive decline and neurodegenerative diseases, driven by synaptic loss, reduced synaptic function, and inflammation. However, the molecular mechanisms underlying these dysfunctions remain unclear. Here, we conducted comparative transcriptomic analyses of brain regions (cortex and hippocampus) and kidney tissues, a peripheral organ with documented age-related dysfunction.

View Article and Find Full Text PDF