98%
921
2 minutes
20
Background: Cognitive dysfunction after traumatic brain injury (TBI) significantly reduces quality of life and imposes a heavy burden on society. A detailed examination of research trends of cognitive dysfunction following TBI has not yet been conducted. This study aimed to examine the bibliometric analysis of cognitive dysfunction after traumatic brain injury over the past 20 years.
Methods: Literature on bibliometric analysis was retrieved from the Web of Science Core Collection (WoSCC) and Science Citation Index Expanded (SCI-E) from 2004 to 2023. The type of literature and the language were refined. A total of 1,902 articles were used for bibliometric analysis, including 1,543 (81.1%) original articles and 359 (18.9%) review articles. Data were retrieved on June 5, 2024.
Results: The publication volume of articles was increasing year by year, with articles published in 537 journals. The , with 130 articles, was the most productive and influential journal. The University of California System led in the number of articles published. There were 9,002 authors from 62 countries/regions. The USA and China were the top-ranked countries by article count. Pandharipande PP authored the highly cited article. Pick CG, as the author with the highest h-index. The top three of author keywords were traumatic brain injury, cognitive impairment, and mild traumatic brain injury. The topics of cognitive dysfunction after TBI were ferroptosis, cognitive decline, spinal cord injury, and prognosis.
Conclusion: Our findings provide valuable insights into cognitive dysfunction following TBI and highlight emerging trends for future research.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893989 | PMC |
http://dx.doi.org/10.3389/fnins.2025.1534735 | DOI Listing |
Nature
September 2025
Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
Loss-of-function variants in the lipid transporter ABCA7 substantially increase the risk of Alzheimer's disease, yet how they impact cellular states to drive disease remains unclear. Here, using single-nucleus RNA-sequencing analysis of human brain samples, we identified widespread gene expression changes across multiple neural cell types associated with rare ABCA7 loss-of-function variants. Excitatory neurons, which expressed the highest levels of ABCA7, showed disrupted lipid metabolism, mitochondrial function, DNA repair and synaptic signalling pathways.
View Article and Find Full Text PDFAlcohol Clin Exp Res (Hoboken)
September 2025
Department of Neuroscience and Experimental Therapeutics, Penn State College of Medicine, Hershey, Pennsylvania, USA.
Background: Prenatal alcohol exposure (PAE) causes fetal alcohol spectrum disorder (FASD) and is associated with various cognitive and sensory impairments, including olfactory dysfunction. While both genetic and environmental factors contribute to olfactory dysfunction, PAE is considered a significant factor affecting brain development, including the olfactory system. In this study, we investigated the impact of PAE on the developing olfactory bulb (OB), specifically focusing on OB RGCs-radial glial cells that give rise to OB projection neurons.
View Article and Find Full Text PDFJ Safety Res
September 2025
MAIC/UniSC Road Safety Research Collaboration, University of the Sunshine Coast, 90 Sippy Downs Drive, Sippy Downs, Queensland 4556, Australia.
Introduction: Despite decades of research and intervention, aggressive driving behavior (ADB) remains a prevalent risk on our roads. This study aimed to systematically review how drivers' personality traits, perceptual tendencies, self-regulatory capacity, and psychological functioning, have been linked to the engagement of ADBs.
Method: Under guidance of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses, a literature search was performed in four databases, followed by a manual search in Google Scholar.
Brain Res
September 2025
Department of Neurology, Shanghai Sixth People's Hospital, Shanghai 200233, China. Electronic address:
Migraine is a complex neurological disorder influenced by multiple genetic susceptibility factors, yet current animal models fail to fully recapitulate its human-specific pathophysiology. In this study, we explored the potential mechanisms underlying migraine by examining functional abnormalities and molecular dysregulation in glutamatergic neurons derived from induced pluripotent stem cells (iPSCs) of migraine patients. As key excitatory cells in the central nervous system, glutamatergic neurons are implicated in migraine through altered excitability, ion channel dysfunction, and dysregulation of nociceptive signaling molecules.
View Article and Find Full Text PDFBrain Res Bull
September 2025
Department of Neuroscience of Disease, Brain Research Institute, Niigata University, Niigata, 951-8585, Japan. Electronic address:
Mutations in the UBE3A gene are responsible for neurodevelopmental disorders (NDDs), including Angelman syndrome (AS), which is characterized by developmental delays, impaired motor coordination, and cognitive disabilities. In recent years, UBE3A mutations have also been linked to autism spectrum disorders (ASD), due to their significant role in synaptic plasticity and cognitive function. Although substantial research has utilized mammalian models, the zebrafish (Danio rerio) provides unique opportunities to investigate gene functions owing to their transparent embryos, rapid development, and suitability for large-scale genetic and behavioral studies.
View Article and Find Full Text PDF