Positive Effects of Caffeine Therapy in a Girl with PDE2A-Related Paroxysmal Dyskinesia.

Mov Disord Clin Pract

Department of Pediatrics, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.

Published: July 2025


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12274993PMC
http://dx.doi.org/10.1002/mdc3.70019DOI Listing

Publication Analysis

Top Keywords

positive effects
4
effects caffeine
4
caffeine therapy
4
therapy girl
4
girl pde2a-related
4
pde2a-related paroxysmal
4
paroxysmal dyskinesia
4
positive
1
caffeine
1
therapy
1

Similar Publications

Prebunking can be used to pre-emptively refute conspiracy narratives. We developed a new approach to prebunking - fighting fire with fire - which introduces a plausible 'meta-conspiracy' suggesting that conspiracy theories are deliberately spread as part of a wider conspiracy. In two preregistered intervention studies, prebunking specific COVID-19 vaccine (Study 1, N = 720) and climate change (Study 2, N = 1077) conspiracy theories (e.

View Article and Find Full Text PDF

Promoting intergenerational altruism among the current youth generation is crucial, and belief in a just world (BJW) may be a protective factor for intergenerational altruism. Inspired by the broaden-and-build theory of positive emotion, our research aims to investigate the relationship between BJW and intergenerational altruism among youths as well as to explore the mediating role of subjective well-being and the moderating role of authenticity in the focal relationship. Three empirical sub-studies with cross-sectional, experimental, and longitudinal designs were performed.

View Article and Find Full Text PDF

Background/aims: Ubiquitin D (UBD), a member of the ubiquitin-like modifier (UBL) family, is significantly overexpressed in various cancers and is positively correlated with tumor progression. However, the role and underlying mechanisms of UBD in rheumatoid arthritis (RA) remain poorly understood. This study aimed to investigate the effects of UBD knockdown on the progression of RA.

View Article and Find Full Text PDF

Objectives: Patients with connective tissue diseases (CTD) have a high incidence of cardiac involvement, which often presents insidiously and can progress rapidly, making it one of the leading causes of death. Multiparametric cardiovascular magnetic resonance (CMR) provides a comprehensive quantitative evaluation of myocardial injury and is emerging as a valuable tool for detecting cardiac involvement in CTD. This study aims to investigate the correlations between CMR features and serological biomarkers in CTD patients, assess their potential clinical value, and further explore the impact of pre-CMR immunotherapy intensity on CMR-specific parameters, thereby evaluating the role of CMR in the early diagnosis of CTD-related cardiac involvement.

View Article and Find Full Text PDF

Bortezomib resistance in multiple myeloma (MM) is a significant clinical challenge that limits the long-term effectiveness. Currently, there is a lack of reliable biomarkers to predict bortezomib resistance. Previous studies reported that several proteins regulate bortezomib resistance through targeting ubiquitin-proteasome pathways, including heat shock protein family A member 9 (HSPA9), dickkopf Wnt signaling pathway inhibitor 1 (DKK1), proteasome 26S subunit non-ATPase 14 (PSMD14), and tripartite motif containing 21 (TRIM21).

View Article and Find Full Text PDF