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Aquaculture is the fastest-growing food industry worldwide because it allows faster intensive production in a limited space and short time. However, the trade-off of this production scheme has led to infectious disease outbreaks that harm food production with economic impacts. Immunostimulants have entered the industry to fight against diseases by enhancing the immune system and conferring better protection against pathogens. In this regard, dietary immunostimulants have been tested at the farm level, such as carbohydrates and proteins known to enhance immunity and improve survival rates under experimental conditions. Despite the success of immunostimulant inclusion in experimental aquaculture, economic evaluation is an innovative avenue to be integrated when a novel immunostimulant is developed. The bioeconomic analysis permits the accurate demonstration of advantages or disadvantages regarding survival and yield performance upon immunostimulant application through mathematical and statistical estimates. An integrative bioeconomic model for testing a novel immunostimulant should contemplate technological, biological, and economic submodels at least; thus, financial variables, such as revenue, costs, and profitability, should also be considered for proper decision-making. Therefore, this perspective briefly describes the most relevant immunostimulants used in shrimp farms and offers bioeconomic elements that should be considered for affordable immunostimulant development and inclusion in shrimp aquaculture.
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http://dx.doi.org/10.3390/ani15020124 | DOI Listing |
Commun Biol
August 2025
Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Sciences, Shandong University, Qingdao, Shandong, China.
Shrimp aquaculture is critically important for global food security, but viral diseases like white spot syndrome virus (WSSV) cause devastating economic losses, highlighting the urgent need for effective disease control strategies. While trained immunity has been observed in invertebrates like shrimp after exposure to pathogens, the underlying molecular mechanisms remain elusive. Here we reveal that lysine acetyltransferase KAT8-mediated histone H3K27ac is critical for antiviral defense in shrimp Marsupenaeus japonicus.
View Article and Find Full Text PDFFish Shellfish Immunol
August 2025
Department of Biology, School of Science, King Mongkut's Institute of Technology Ladkrabang, Bangkok, 10520, Thailand.
Cyclophilin A (CypA) is a highly conserved peptidyl-prolyl isomerase that plays a crucial role in protein folding, immune regulation, and cellular stress responses. In shrimp, CypA has been implicated in innate immunity, particularly in response to viral and bacterial infections. This study investigates the role of the Penaeus monodon cyclophilin A (PmCypA) in shrimp infected with V.
View Article and Find Full Text PDFJ Fish Dis
August 2025
Laboratory of Genome Science, Tokyo University of Marine Science and Technology, Tokyo, Japan.
Gut bacterial communities play a key role in shrimp health; thus, their modulation has been a target of dietary supplements which also function in enhancing disease and stress resistance of shrimp. However, this also raised the question of whether immunostimulants yield distinct changes in the gut bacterial composition or whether there are consistent features across all treatments. Here, we performed a machine learning-aided meta-analysis of 16S rRNA gut bacterial community studies of immunostimulants for Penaeus vannamei.
View Article and Find Full Text PDFFish Shellfish Immunol
July 2025
Fujian Key Laboratory on Conservation and Sustainable Utilization of Marine Biodiversity, Fuzhou Institute of Oceanography, Minjiang University, Fuzhou, 350108, China. Electronic address:
Decapod iridescent virus 1 (DIV1) infection has caused severe economic losses in shrimp aquaculture industry. Passive immunization with neutralizing antibodies is a promising method to control DIV1 infection. In this study, a single domain antibody D13 vNAR targeting the major capsid protein of DIV1 was isolated.
View Article and Find Full Text PDFVet World
June 2025
Department of Fisheries, Faculty of Fisheries and Marine Science, University of Jenderal Soedirman, Purwokerto, Indonesia.
Background And Aim: Infectious myonecrosis virus (IMNV) is a significant pathogen affecting , causing high mortality and substantial economic losses in shrimp aquaculture. Conventional chemotherapeutics have limited efficacy and raise environmental concerns. This study explores the immunostimulatory potential of squid ( spp.
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