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Existing lower limb exoskeletons (LLEs) have demonstrated a lack of sufficient patient involvement during rehabilitation training. To address this issue and better incorporate the patient's motion intentions, this paper proposes an online brain-computer interface (BCI) system for LLE based motor imagery and stacked ensemble. The establishment of this online BCI system enables a comprehensive closed-loop control process, which includes the collection and decoding of brain signals, robotic control, and real-time feedback mechanisms. Additionally, an online experimental protocol that integrates visual and proprioceptive feedback is developed. To enhance decoding precision, we proposed a novel classification algorithm based on the stacking technique, termed weighted random forests-support vector machines (WRF-SVM). In this algorithm, WRFs function as the base learning models, while SVMs act as the meta-learning layer. To assess the efficacy of the BCI system and the classification algorithm, eight subjects were recruited for testing. The outcomes of both online and offline experiments exhibit high classification accuracy, confirming the viability and utility of the BCI system. We are confident that our approach holds significant promise for practical applications in the field of LLE technology.
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http://dx.doi.org/10.1063/5.0232481 | DOI Listing |
Adv Sci (Weinh)
September 2025
School of Graduate Study, University of Chinese Academy of Sciences, Beijing, 100049, China.
Brain-computer interfaces (BCIs) enable communication between individuals and computers or other assistive devices by decoding brain activity, thereby reconstructing speech and motor functions for patients with neurological disorders. This study presents a high-resolution micro-electrocorticography (µECoG) BCI based on a flexible, high-density µECoG electrode array, capable of chronically stable and real-time motor decoding. Leveraging micro-nano manufacturing technology, the µECoG BCI achieves a 64-fold increase in electrode density compared to conventional clinical electrode arrays, enhancing spatial resolution while featuring scalability.
View Article and Find Full Text PDFIEEE J Biomed Health Inform
September 2025
The brain-computer interface (BCI) system facilitates efficient communication and control, with Electroencephalography (EEG) signals as a vital component. Traditional EEG signal classification, based on static deeplearning models, presents a challenge when new classes of the subject's brain activity emerge. The goal is to develop a model that can recognize new few-shot classes while preserving its ability to discriminate between existing ones.
View Article and Find Full Text PDFCell Regen
September 2025
Center for Translational Neural Regeneration Research, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310016, China.
Neural regeneration stands at the forefront of neuroscience, aiming to repair and restore function to damaged neural tissues, particularly within the central nervous system (CNS), where regenerative capacity is inherently limited. However, recent breakthroughs in biotechnology, especially the revolutions in genetic engineering, materials science, multi-omics, and imaging, have promoted the development of neural regeneration. This review highlights the latest cutting-edge technologies driving progress in the field, including optogenetics, chemogenetics, three-dimensional (3D) culture models, gene editing, single-cell sequencing, and 3D imaging.
View Article and Find Full Text PDFNeuroscience
September 2025
College of Electrical and Control Engineering, Xi'an University of Science and Technology, Xi'an 710054, China; Xi'an Key Laboratory of Electrical Equipment Condition Monitoring and Power Supply Security., Xi'an 710054, China.
Motor imagery (MI) based brain-computer interfaces (BCI) decode neural activity to generate command outputs. However, the limited number of distinguishable commands in traditional MI-BCI systems restricts practical applications. To overcome this limitation, we propose a multi-character classification framework based on Electroencephalography (EEG) signals.
View Article and Find Full Text PDFFront Neurorobot
August 2025
Technology Research Institute, Arrow Technology Company, ZhuHai, China.
Brain-computer interface (BCI) integration with virtual reality (VR) has progressed from single-limb control to multi-limb coordination, yet achieving intuitive tri-manual operation remains challenging. This study presents a consumer-grade hybrid BCI-VR framework enabling simultaneous control of two biological hands and a virtual third limb through integration of Tobii eye-tracking, NeuroSky single-channel EEG, and non-haptic controllers. The system employs e-Sense attention thresholds (>80% for 300 ms) to trigger virtual hand activation combined with gaze-driven targeting within 45° visual cones.
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